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Composition capable of reducing blood pressure and/or suppressing rise in blood temperature and drink containing same

A technology of blood pressure elevation and composition, which is applied in the field of food, beverage, and effective utilization of unused resources, and can solve the problems of unknown and long-term blood pressure regulation function of mannan oligosaccharides

Inactive Publication Date: 2009-08-26
AJINOMOTO GENERAL FOODS INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few examples of developing food and beverages that can be easily, safely and economically used in daily life without compromising the taste of ordinary food and beverages, and can prevent high blood pressure, and it takes a long time for the effect to appear
The applicant has found that in food materials containing many mannans, mainly from the hydrolyzate of coffee extract residues, the sugar residues other than mannose residues in the sugar chains are less, the degree of polymerization is more than 1, and 10 molecules The following mannooligosaccharides have excellent intestinal regulation function accompanied by bifidobacteria proliferation, serum fat improvement function, etc., but it is completely unknown whether mannooligosaccharides have blood pressure regulation function

Method used

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  • Composition capable of reducing blood pressure and/or suppressing rise in blood temperature and drink containing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Preparation of mannan oligosaccharides

[0052] Roasted and ground coffee obtained by a conventional method is extracted with a commercially used percolation system, and the coffee extraction residue remaining after use is used.

[0053] In order to easily feed the coffee extraction residue into the reactor, it was first pulverized to a particle size of about 1 mm. Next, a slurry containing water and the pulverized product with a total solid content concentration of about 14% by weight was prepared, and heat-treated in a 4 m hot plug flow reactor. At a speed corresponding to a residence time of 8 minutes, it is pumped together with high-pressure steam into a plug flow reactor, using a 6.35mmφ orifice plate, and kept at about 210°C. The reaction was then quenched by sparging out at atmospheric pressure. The resulting slurry was filtered to separate a liquid containing soluble solid components from insoluble solid components. This liquid containing soluble solids was...

Embodiment 2

[0056] Validate the effect of mannan oligosaccharides on blood pressure through clinical experiments

[0057] To study the effect of drinking beverages containing mannan oligosaccharides on blood pressure.

[0058] The experiment was implemented by double-blind method. Subjects with BMI≥25kg / m 224 men and 24 men each were used as subjects, and the BMIs of the groups were approximately the same, and they were divided into two groups: the control group n=24 and the mannan-oligosaccharide intake group n=24. The test drink was liquid coffee, diluted with water to espresso extract and artificial sweetener, sterilized by UHT, and then filled into a 900mL PET bottle. This was used as the test drink of the control group. The test drink of the mannooligosaccharide ingestion group was obtained by adding a mannooligosaccharide-containing liquid (6 g / 300 mL of mannooligosaccharide) to the liquid coffee. The subjects were asked to drink 300mL / day for 12 consecutive weeks, and blood p...

Embodiment 3

[0061] Validation experiment of the effect of mannan oligosaccharides on the blood pressure of rats induced by hypertension

[0062] Test animals and feeding conditions

[0063] In the experiment, rats that developed hypertension due to salt (salt-sensitive hypertensive rats, Dahl S / Jr Sea) were used. Rats were preliminarily fed for a week including quarantine and acclimatization, and individuals with no abnormalities in body weight changes and normal conditions were used for the experiment. Breeding is carried out by controlling temperature and humidity in a cycle of 12 hours each in light and dark. After preliminary feeding, a group of 5 animals was divided into two groups, a control group and a mannooligosaccharide-administered group, so that the average body weights were approximately equal.

[0064] As feed, 300 g of edible oil was added to 700 g of powdered feed for general feeding, and as drinking water, 2% saline was put into a water bottle to allow free intake to ...

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Abstract

The invention provides a composition capable of reducing blood temperature and / or suppressing rise in blood pressure, which is characterized by containing mannanoligosaccharides formed by combining more than one and less than ten molecules of mannose-based monosaccharides; and the invention also provides a drink containing the composition. The composition of the invention can easily and economically provide an economical, simple and convenient drink which is originated from food, characterized by food, high in safety, and capable of reducing blood pressure and / or suppress rise in blood pressure for daily food and drink life without substantially change in the daily food and drink life.

Description

technical field [0001] The present invention relates to a composition having an effect of lowering blood pressure and / or an effect of suppressing an increase in blood pressure, mainly composed of oligosaccharides, wherein the oligosaccharides contain mannose as a main constituent sugar; Orally ingestible compositions, especially beverages and foods. The invention also relates to efficient utilization of unutilized resources. Background technique [0002] Coffee extraction residues were almost always incinerated or disposed of as industrial waste in the past. In recent years, coffee extraction residues have been used as compost materials or activated carbon materials. However, this is not sufficient from the viewpoint of high utilization of unused resources, and further establishment of methods for high utilization of coffee extraction residues is an important issue. [0003] At present, lifestyle diseases such as high blood pressure, diabetes, and hyperlipidemia, which are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7004A61K31/702A23F5/24A61P9/00A23L1/30C07H3/00A23L2/52C08B37/14A61K31/7016
CPCA23V2002/00A61K31/702A61K31/7004C08L5/00A61K31/405A23F5/40A61K31/7016A23F5/243A23L1/30A23L2/52A23L1/3081A23L1/3002A23L33/10A23L33/105A23L33/22A61P9/00A61P9/12A23V2250/618A23V2200/326A61K31/715
Inventor 高尾和泉浅野一朗藤井繁佳金子正行J·R·尼尔森D·G·斯蒂芬T·哈措尔德
Owner AJINOMOTO GENERAL FOODS INC
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