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Method for preparing biocompatible high-strength three-dimensional connected porous PVA hydrogel

A biocompatible, high-strength technology, applied in the field of biomedical materials, can solve the problems of inability to obtain a porous structure, time-consuming pore-forming agents, and many closed-pore structures, and achieves a solution that avoids early dissolution, is easy to operate, and has a uniform pore size. Effect

Inactive Publication Date: 2009-09-30
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that it takes time to remove the porogen, and there are many closed-cell structures and poor porosity.
For the aqueous solution system and the PVA hydrogel formed by freeze-thaw physical cross-linking, the above methods cannot obtain a porous structure.

Method used

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  • Method for preparing biocompatible high-strength three-dimensional connected porous PVA hydrogel
  • Method for preparing biocompatible high-strength three-dimensional connected porous PVA hydrogel
  • Method for preparing biocompatible high-strength three-dimensional connected porous PVA hydrogel

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] Weigh different masses of PVA solid particles and mix them with deionized water to prepare PVA aqueous solutions with three different concentrations of 10%, 15% and 20%, and put them into a high-pressure steam container to heat and dissolve, and the pressure in the container is maintained at 110MPa , the temperature was 110°C, and after heating for 1.5 hours, the homogeneously dissolved PVA solution was taken out, and allowed to stand to cool to room temperature. Add the same mass of OP-sodium chloride particles mixed porogen 10g (mass ratio 1:1) dropwise to the three solutions respectively, and stir at a speed of 100r / min at the same time. Pour the mixed PVA solution into a stainless steel mold, freeze at -20°C for 10 hours, and then thaw at room temperature for 3 hours, and freeze and thaw 6 times in this cycle. After the sample was formed, it was placed in a water bath at 25°C and cleaned with an ultrasonic cleaner for 0.5 hours to obtain the final sample. The test ...

example 2

[0026] Weigh a certain amount of PVA solid particles, mix it with deionized water to prepare a PVA aqueous solution with a concentration of 15%, put it into a high-pressure steam container and heat it to dissolve. The pressure in the container is maintained at 120MPa and the temperature is 120°C. The homogeneously dissolved PVA solution was taken out, allowed to stand and cooled to room temperature, and 50 g of the solution was equally weighed and placed in three beakers. Weigh 5g, 10g, 50g of OP-sodium chloride particle mixed porogen (mass ratio 1:1) into three beakers and mix with PVA solution. Stir evenly at a speed of 100r / min, pour the solution into a stainless steel mold, freeze at -20°C for 10 hours, then thaw at room temperature for 3 hours, and freeze and thaw 6 times in this cycle. After the sample was formed, it was placed in a water bath at 25°C and cleaned with an ultrasonic cleaner for 1 hour to obtain the final sample. The test results show that with the increa...

example 3

[0028]Different amounts of OP and NaCl solid particles were weighed and mixed to prepare three OP-sodium chloride particle mixed porogens with mass ratios of 2:1, 1:1, and 1:2. Weigh a certain amount of PVA solid particles, mix it with deionized water to prepare a PVA aqueous solution with a concentration of 15%, put it into a high-pressure steam container and heat it to dissolve. The pressure in the container is maintained at 120MPa and the temperature is 120°C. Take out the homogeneously dissolved PVA solution and let it cool down to room temperature. 50 g of the solution was weighed in equal amounts and placed in three beakers, and 5 g of three mixed porogens with different proportions were added respectively, while stirring at a speed of 90 r / min. Pour the uniformly mixed solution into a stainless steel mold, freeze at -20°C for 10 hours, then thaw at room temperature for 3 hours, and freeze and thaw 6 times in this cycle. After the sample was formed, it was placed in a w...

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Abstract

The invention relates to a method for preparing biocompatible high-strength three-dimensional connected porous polyvinyl alcohol hydrogel, which belongs to the field of biomedical materials. The invention particularly relates to preparation of the porous polyvinyl alcohol hydrogel as an in vivo implantation restoration material and a tissue induction regeneration carrier. The method adopts process methods of high temperature and high pressure dissolving, composite pore forming with a surfactant and soluble solid particles, physical cross-linking forming through circulating refrigeration and dissolving, and cleaning with ultrasonic waves to prepare the three-dimensional porous polyvinyl alcohol hydrogel. The method overcomes the defect that a single pore-forming agent is easy to cause closed and isolated pore spaces, and obtains a network structure with higher porosity, grading connection of the pore spaces and even aperture. The prepared porous polyvinyl alcohol hydrogel has adjustable aperture sizes from 10 to 400 microns and controllable shapes; and the porosity can reach between 50 and 85 percent, thus the porous polyvinyl alcohol hydrogel can be used as a regeneration carrier for inductive tissues of cartilages, blood vessels, skins and the like, is advantageous for the growth of cells, the ingrowth of blood vessel nerves and the transmission of various nutrient substances and has excellent mechanical property, and the modulus of elasticity is between 3.5 and 8.1 MPa.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to the preparation of porous polyvinyl alcohol hydrogel as a repair material for implantation in vivo and a tissue induction regeneration carrier. Background technique [0002] Porous materials with biocompatibility and good mechanical properties have broad application prospects in the field of biomedicine as implant repair materials and tissue-induced regeneration carriers. Because it can allow tissue cells to grow in and firmly combine with the tissue after being implanted into the organism, it is beneficial to restore, maintain or change the shape and function of damaged tissues and organs. As tissue-induced regeneration carriers and tissue engineering scaffold materials, porous materials are required to have a three-dimensional interconnected pore structure and sufficient porosity to provide sufficient space for cell adhesion, differentiation and growth. Hydrogel...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L29/04
Inventor 郑裕东孟昊业吕鹤翔杨槐姚学锋刘国权
Owner UNIV OF SCI & TECH BEIJING
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