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Application of walnut shell flavone extract to preparation of medicines for treating intestinal flora alternation

A technology of intestinal flora imbalance and intestinal flora, applied in the field of medicine, can solve problems such as treatment and regulation of intestinal flora with walnut shell flavonoid extracts that have not yet been seen

Inactive Publication Date: 2018-01-19
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the use of walnut shell flavonoids extract for treatment and regulation of intestinal flora in the prior art

Method used

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  • Application of walnut shell flavone extract to preparation of medicines for treating intestinal flora alternation
  • Application of walnut shell flavone extract to preparation of medicines for treating intestinal flora alternation
  • Application of walnut shell flavone extract to preparation of medicines for treating intestinal flora alternation

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preparation example Construction

[0028] The preparation concrete operation of described walnut shell flavone extract is as follows:

[0029] Wash the walnut shells, dry them, and crush them through 80-100 mesh sieves. Use 55-65% ethanol aqueous solution with a liquid-to-material ratio of 30-35:1 at a temperature of 75-80°C for 1-2 hours per hour. Reflux extraction for 2 to 3 times, combine the filtrates and recover ethanol, then freeze-dry or spray-dry to obtain walnut shell flavonoid extract.

[0030] The dosage form of the medicine for treating intestinal flora imbalance includes tablet, electuary, capsule, drop pill or powder of drinkable suspension.

[0031] The medicine for treating intestinal flora imbalance consists of the walnut shell flavone extract and a pharmaceutically acceptable carrier.

[0032] The pharmaceutically acceptable carrier includes one of fillers, binders, disintegrants, lubricants, suspending agents, wetting agents, solvents, surfactants, flavoring agents or pharmaceutically accept...

experiment example

[0036] 1 Materials and methods

[0037] 1.1 Materials

[0038] 1.1.1 Raw materials and reagents

[0039]Walnut shells were purchased from Yangbi County, Dali, Yunnan, China; triglyceride (TG) assay kits, total cholesterol (TC) assay kits, high-density lipoprotein (HDL-C) assay kits, low-density lipoprotein (HDL-C) assay kits ) assay kit (Sinobio Biotechnology Co., Ltd.); aspartate aminotransferase (AST) kit, alanine aminotransferase (ALT) kit (Nanjing Jiancheng Biotechnology Co., Ltd.); normal saline (Kunming Nanjiang Pharmaceutical Co. company).

[0040] 1.1.2 Instruments

[0041] INFINITE M200PRO microplate reader (Switzerland TECAN company); UV759S ultraviolet-visible spectrophotometer (Shanghai Precision Scientific Instrument Co., Ltd.); Xiangyi H1850R desktop high-speed refrigerated centrifuge (Hunan Xiangyi Laboratory Instrument Development Co., Ltd.); DY89-Ⅱ Type electric glass homogenizer (Ningbo Xinzhi Biotechnology Co., Ltd.); syringes, centrifuge tubes, etc.

...

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Abstract

The invention discloses application of walnut shell flavone extract to preparation of medicines for treating intestinal flora alternation. The intestinal flora alternation is as follows: in the intestinal flora caused by high fat diet, the microbial abundance related to emaciation is obviously reduced and the microbial abundance related to obesity is obviously increased. According to the walnut shell flavone extract, the rat experiment results indicate that through supplementation of the walnut shell flavone extract, the intestinal flora alternation caused by the fact that the microbial abundance related to emaciation is obviously reduced and the microbial abundance related to obesity is obviously increased in the intestinal flora caused by high fat diet can be reversed, so that the intestinal flora can return to normal.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the use of walnut shell flavone extracts in the preparation of medicines for treating intestinal flora imbalance. Background technique [0002] Walnut ranks first among the four major dried fruits and is a traditional Chinese medicine recorded in the Pharmacopoeia of my country. In recent years, my country's walnut industry has shown a strong momentum of development, and the cultivated area is increasing at a rate of 10% every year. It has become a pillar industry in many places. my country's walnut planting area and output both rank first in the world, and Yunnan Province ranks first in the country. Walnut is full of treasures, and it is a multi-functional green economic species with ecological value, economic value and social value, and has great potential for comprehensive development and utilization. Walnut shells are the waste after walnut kernels are harvest...

Claims

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Application Information

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IPC IPC(8): A61K36/52A61P1/00A61P3/06A61P3/04
Inventor 赵声兰罗燕刘竞元陈朝银杨映宁
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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