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A gel and ophthalmic technology, applied in the field of medicine, can solve the problems of inaccurate clinical dosage, difficult production process operation, inconvenient application, etc., and achieve the effect of improving bioavailability, high transparency, and good fluidity
Inactive Publication Date: 2009-10-28
BEIJING HERUN INNOVATION PHARMA TECH DEV
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Although eye ointment can maintain a certain drug concentration for a long time, it is generally only applied before going to bed at night, because the patient's vision will be affected after applying the ointment, and he can't see things clearly. Eye vision is required, which is also the shortcoming of eye ointmen
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[0091] Preparation method: Take 4000ml of water for injection, add gellan gum, stir evenly, place in a boiling water bath, stir until clear, add 60g of boric acid, 3g of borax, 4g of ethyl paraben, stir until clear, heat to 60°C, Porous filter membrane (0.8μm), add gatifloxacin under stirring, stir well, add water for injection to 5000ml, pass through microporous filter membrane (0.22μm), aseptically dispense, and obtain.
[0094] Preparation method: Add gellan gum, boric acid and borax to 2700ml of water for injection, heat to boil, cool to 80°C, add sodium foscarnet, cool down to 60°C while stirring, then add 1.5g of ethylparaben, and add injection Make up to 3000ml with water, stir evenly, pass through a microporous membrane (0.22μm), and aseptically dispense, to obtain.
[0097] Preparation method: Take gellan gum, boric acid, and borax, add them to 4000ml of water for injection, heat to boil, cool to 80°C, add ciprofloxacin lactate, cool down to 60°C while stirring, add 2.5g of ethylparaben, stir Mix well, add water for injection to 5000ml, pass through a microporous membrane (0.22μm), and aseptically dispense to obtain.
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Abstract
The invention discloses a medicinal in situ forming eye gel preparation, and belongs to the field of pharmacy. Active ingredients of the preparation come from bulk medicaments of the medicament, gel base materials of the preparation mainly comprise Gellan gum which is 0.4 to 0.7 percent of the weight of a finished product. The technical proposal overcomes the defects of low bioavailability, inconvenient use, short detention time and the like of the prior eye preparation, and achieves the effects of reducing applied dosage, prolonging the detention time in the eyes, convenient use, accurate applied dosage and the like.
Description
technical field [0001] The invention relates to an instant ophthalmic gel preparation for medicine, in particular to an instant ophthalmic gel preparation with gellan gum as the main gel base material, belonging to the field of medicine. Background technique [0002] Among the current ophthalmic preparations, eye drops, as a traditional dosage form, have the advantages of convenient use, good compliance, and low price. big impact. Studies have shown that the volume of a drop of eye drops is basically between 25 and 50ul. If you do not blink, the volume of the liquid in the eye is only 30ul, and if you blink, it will be reduced to 10ul. Therefore, most of the externally used drugs do not enter the eye tissue. Instead, it drains through the nasolacrimal system and eyelid crevices. According to tear dynamics, the residence time of ophthalmic solutions on the ocular surface is very short, and the amount of drug absorbed is usually only a small part of the dose, even if it is o...
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Application Information
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