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Inhalation aerosol of plant extract for treating asthma and preparation method

A plant extract, aerosol technology, applied in aerosol delivery, plant raw materials, medical preparations containing active ingredients, etc. Efficacy and low toxicity

Inactive Publication Date: 2009-11-04
浙江省中药研究所有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Chinese patent [Application No.: 99107980.9] discloses a kind of aerosol for treating angina pectoris and coronary heart disease prepared from styrax and borneol as the main ingredients, but in the technical scheme announced by it, the propellant used is Dichlorodifluoroethane, that is, Freon F12, has gradually lost its practicality under the current requirement of replacing Freon
[0008] Chinese patent [Application No.: 200510061804.3] discloses an aerosol for the treatment of asthma prepared from several natural plant extracts such as Neem chinensis, Ginkgo fruit, walnut meat, psoraleae, coltsfoot flower, dew honeycomb, etc. F12 is also used as a propellant in its prescription, facing the trend of replacement of Freon, it will also face the situation of losing practicality
[0010] Due to the complexity of the pathogenesis of asthma, for different patients, the treatment effect is often unsatisfactory, and most of the drugs are treated by oral or injection, which have great side effects

Method used

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  • Inhalation aerosol of plant extract for treating asthma and preparation method
  • Inhalation aerosol of plant extract for treating asthma and preparation method
  • Inhalation aerosol of plant extract for treating asthma and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040]800 grams of ephedra was extracted with water, the first time was 10 times the weight of water extraction for 2 hours, the second time was 8 times the weight of water extraction for 2 hours, filtered, the two filtrates were combined, concentrated under reduced pressure to a relative density of 1.2, and saturated NaoH solution was added to pH12, extracted three times with ether of 1 times weight each time, combined the extracts, reclaimed the ether until the ether was collected to get 3 grams of ephedrine extract, determined the content of total ephedrine (77%), and set aside.

[0041] Add 4 times the weight of water to 820 grams of Asarum and 2000 grams of Folium Artemisiae Argyi, and steam distill for 5 hours to extract the volatile oil to obtain 16.5ml of Asarum Oil and 10ml of Folium Artemisiae Argyi Oil for later use;

[0042] 500 grams of peppercorns, extract the peppercorns oil through supercritical extraction, the extraction temperature is 45°C, the pressure is 28M...

Embodiment 2

[0045] Ephedra 220 grams, extracted with water, the first 10 times the weight of water extraction for 2 hours, the second 8 times the weight of water extraction for 2 hours, filtered, combined two filtrates, concentrated under reduced pressure to a relative density of 1.2, added saturated NaoH solution To pH is 11, extracts three times with 1 times weight of diethyl ether at every turn, merges extract, reclaims diethyl ether until diethyl ether is collected as far as possible, obtains 1.3 grams of ephedrine extractum, measures the content (75%) of ephedrine total alkaloids, spare.

[0046] Add 5 times the weight of water to 125 grams of Asarum and 3000 grams of Folium Artemisiae Argyi, and steam distill for 5 hours to extract the volatile oil to obtain 2.8ml of Asarum Asarum Oil and 15ml of Folium Artemisiae Argyi Oil for later use.

[0047] 200 grams of peppercorns, extract the peppercorns oil through supercritical extraction, the extraction temperature is 45°C, the pressure ...

Embodiment 3

[0051] Ephedra 600 grams, extracted with water, the first 9 times the weight of water extraction for 2 hours, the second 8 times the weight of water extraction for 2 hours, filtered, combined two filtrates, concentrated under reduced pressure to a relative density of 1.2, added saturated NaoH solution To PH13, extract with ether of 1 times weight each time, extract three times, combine the extracts, reclaim the ether until the ether is collected to get 3.6 grams of ephedrine extract, measure the content of total alkaloids of ephedrine (75%), and set aside.

[0052] Add 4 times the weight of water to 250 grams of Herba Asarum and 1000 grams of Folium Artemisiae Argyi, and extract the volatile oil through steam distillation for 5 hours to obtain 5.8ml of Asarum Oil and 5ml of Folium Artemisiae Argyi Oil for later use;

[0053] 100 grams of peppercorns, extract the peppercorns oil through supercritical extraction, the extraction temperature is 45°C, the pressure is 28Mpa, extract ...

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Abstract

The invention provides an inhalation aerosol of plant extract for treating asthma and a preparation method. The plant extract for treating asthma is prepared from the following materials by the weight portion: 5 to 20 of bunge pricklyash seed, 12 to 85 of argy wormwood leaf, 5 to 35 of asarum and 5 to 35 of Chinese ephedra. The invention is characterized in that lipophilic plant extract is initiatively mixed with hydro-fluoro alkane with relatively larger polarity for preparing a quantitative inhalation aerosol of plant extract. When sprayed out, the medicament changes into small milky particles after touching water, and the milky particles are adsorbed quickly by human body to take effect. The prepared inhalation aerosol reduces medicament irritation and toxicity, enhances medicament absorption rate and transmucosal property, further enhances medicament bioavailability, strengthens medicament curative effect, and improves the medicament taking adaptability of patients.

Description

technical field [0001] The invention relates to a traditional Chinese medicine plant extract aerosol for treating asthma and a preparation method. Background technique [0002] In the theory of traditional Chinese medicine, asthma is a disease with "permanent roots". It is a disease that occurs immediately when it is cold, tired, or hot, and it can also occur when it is improperly eaten or lived. The occurrence and development of this disease are mostly caused by the evil of exogenous pathogenic factors and six evils due to wrong treatment, causing the evil to linger in the lungs, the lungs fail to descend, and the body fluid does not gather and produce phlegm, which is stored in the lungs. There are also improper diets, long-term food cold, Fat and sweet products or imbalance between work and rest will cause spleen and stomach injury, abnormal lifting and lowering, lack of temper, and inability to circulate body fluid for the stomach. Qi, the diaphragm has colloidal phlegm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/758A61K9/12A61P11/06
Inventor 杨苏蓓闻聪余琪金方冯瑛周丹英
Owner 浙江省中药研究所有限公司
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