Method for extracting and purifying 7-xylose-10-deacetyl paclitaxel from taxus cuspidata

A technology of acetyl paclitaxel and yew, applied in chemical instruments and methods, separation methods, sugar derivatives, etc., can solve the loss of 7-xylose-10-deacetyl paclitaxel, long purification process, backward extraction process, etc. problem, to achieve the effect of simple and easy method, short cycle, efficient and reasonable utilization
CN101575356AInactive Publication Date: 2009-11-11NORTHEAST FORESTRY UNIVERSITY +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NORTHEAST FORESTRY UNIVERSITY
Publication Date
2009-11-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for extracting and purifying a functional element from a traditional Chinese herb and aims at providing a convenient, safe, economical and efficient method for extracting and purifying 7-xylose-10-deacetyl paclitaxel which is a monomeric compound from taxus cuspidata. The technical proposal adopted by the invention comprises the steps: fresh or dried leaves of taxus cuspidate are taken as raw materials, and macroporous adsorption resin enrichment technology, normal-pressure chromatography preparation technology and high-pressure liquid phase separation technology are combined to prepare the 7-xylose-10-deacetyl paclitaxel with the purity higher than 99.90 percent at an extraction rate of 0.05 percent. The raw materials used in the invention can be waste materials from the paclitaxel production, thus fully utilizing natural resources. Moreover, the method comprises extraction, primary impurity removal and repurification, thus being simple and easy; and the loss of the target compound is low.
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Description

technical field

[0001] The invention relates to a method for separating and purifying functional components from plants, in particular to extracting and purifying 7-xylose-10-deacetyl paclitaxel from fresh or dry branches and leaves of Taxus chinensis. Background technique

[0002] Paclitaxel is widely used in the treatment of ovarian cancer, breast cancer, lung cancer and other tumors. However, because it is insoluble in water, it needs to be dissolved in a mixed solvent of polyoxyethylene castor oil (cremophor EL) and absolute ethanol to increase water solubility, and polyoxyethylene castor oil (cremophor EL) releases histamine when degraded in the body, resulting in Different degrees of allergic reactions can also cause granule release and demyelination changes in nerve cells and aggravate the peripheral neurotoxicity of paclitaxel. In order to reduce toxicity and improve its curative effect, synthetic and semi-synthetic paclitaxel compounds are one of the methods to sol...

Claims

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