Method for preparing Chinese traditional medicinal compound salvia miltiorrhiza preparation for curing cardiovascular and cerebrovascular diseases

A technology of cardiovascular and cerebrovascular diseases and compound salvia miltiorrhiza, applied in the field of preparation of traditional Chinese medicine compound salvia miltiorrhiza, can solve the problems of no temperature control, loss of salvianolic acid B, destructive activity, etc., and achieve less damage, less toxic and side effects, and convenient administration Effect

Inactive Publication Date: 2009-11-25
耿福能
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, according to "Chinese Pharmacopoeia" in 2005, a compound Danshen tablet needs to be extracted three times, add ethanol to reflux for 1.5 hours for the first time, filter, recover ethanol from the filtrate and concentrate it to an appropriate amount, and set aside; hour, the extract was filtered, the filtrate recovered ethanol and concentrated to an appropriate amount, and set aside; the dregs were decocted with water for 2 hours, the decoction was filtered, and the filtrate was concentrated to an appropriate amount. Salvianolic acid B is seriously lost due to prolonged heating; in the invention patent (Patent No. ZL 02157377.8) "a compound salvia miltiorrhiza preparation for treating cardiovascular and cerebrovascular diseases and its preparation method", the temperature of salvia miltiorrhiza was not controlled when the water was extracted, so that a large amount of salvia miltiorrhiza Destruction of Phenolic Acid B into Danshensu and Protocatechualdehyde with Low Activity under High Temperature

Method used

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  • Method for preparing Chinese traditional medicinal compound salvia miltiorrhiza preparation for curing cardiovascular and cerebrovascular diseases
  • Method for preparing Chinese traditional medicinal compound salvia miltiorrhiza preparation for curing cardiovascular and cerebrovascular diseases
  • Method for preparing Chinese traditional medicinal compound salvia miltiorrhiza preparation for curing cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Weigh 13.5kg of Danshen medicinal material, cut into slices, soak and extract 3 times in water at 80°C, each time the weight of water used is 8 times the weight of the medicinal material, and filter for 1 hour each time to obtain filtrate A; 4.24kg of Radix Notoginseng, crushed into coarse Granules, decocted and extracted 3 times, the weight of the water used each time is 8 times the weight of the medicinal material, and filtered for 1.5 hours each time to obtain the filtrate B; combine the filtrate B and the filtrate A, adjust the pH = 3, stir well, and statically Put it in place for 1 hour, centrifuge, and the supernatant passes through the pretreated HPD-100 macroporous adsorption resin column, washes with water until the reducing sugar reaction of the effluent is negative, and then washes with 75% ethanol (eluent) until the effluent has no color, collect the eluate, recover ethanol, concentrate to a relative density of 1.1, add ethanol until the alcohol content reach...

Embodiment 2

[0024] Weigh 14kg of Salvia miltiorrhiza, cut into slices, soak and extract 3 times in water at 70°C, each time the weight of water used is 10 times the weight of the medicinal material, and filter for 1 hour each time to obtain filtrate A; 3.8kg of notoginseng, crushed into coarse particles , decocted and extracted 3 times, the weight of the water used each time is 10 times the weight of the medicinal material, and filtered for 2 hours each time to obtain the filtrate B; combine the filtrate B and the filtrate A, adjust the pH=5, stir well, and let stand Centrifuge for 1 hour, and the supernatant is passed through the pretreated AB-8 macroporous adsorption resin column, washed with water until the reducing sugar reaction of the effluent is negative, and then washed with 70% ethanol (eluent) until the effluent is colorless , collect the eluent, recover ethanol and concentrate into extract, dry at 75°C under reduced pressure (vacuum degree: -0.07Mpa), and pulverize to obtain ext...

Embodiment 3

[0027] Weigh 13kg of Salvia miltiorrhiza, cut into slices, immerse and extract 3 times in water at 65°C, use 9 times the weight of the water for each time, filter for 1.5 hours each time, and obtain filtrate A; Panax notoginseng 4.78kg, slice into slices, decoct in water Boil and extract 3 times, the weight of the water used each time is 9 times the weight of the medicinal material, and filter for 1.5 hours each time to obtain the filtrate B; combine the filtrate B and the filtrate A, adjust the pH=3, stir well, and let it stand for 1 hour, After centrifugation, the supernatant was passed through a pretreated D-101 macroporous adsorption resin column, washed with water until the reducing sugar reaction of the effluent was negative, and then washed with 75% ethanol (eluent) until the effluent was colorless, and collected and washed. Remove the liquid, recover ethanol, concentrate to a relative density of 1.15, add 95% ethanol until the alcohol content reaches 85%, store in cold ...

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Abstract

The invention discloses a method for preparing Chinese traditional medicinal compound salvia miltiorrhiza preparation for curing cardiovascular and cerebrovascular diseases, comprising the following steps: choosing salvia miltiorrhiza crude medicaments; slicing or crashing the salvia miltiorrhiza crude medicaments into coarse particles; extracting with water for 2-4 times at 20-80 DEG C; adding 4-12 quantities of water respectively for extracting for 1-3 hours; choosing panax notoginseng crude medicaments; slicing or crashing the panax notoginseng crude medicaments into coarse particles; adding water for decoction and extraction for 2-4times; adding 4-12 quantities of water respectively for decoction and extraction for 1-3 hours; combining extract of salvia miltiorrhiza water and extract of panax notoginseng water; regulating pH to be 1-7; mixing uniformly, standing for 0.5-12 hours; filtering or centrifuging; attaching supernatant fluid through macroporous to a resin column; washing until the effluent liquid reduces sugar to be negative; abandoning the washing liquid; using 30-100% of ethanol for elution; collecting elution liquid; recycling ethanol from the elution liquid; concentrating and drying the ethanol to obtain the extract of salvia miltiorrhiza and panax notoginseng; adding borneol flakes and accessories for preparing tablets, capsules, soft capsules, oral solution, dripping pills, spraying agents or granules.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a preparation method of a traditional Chinese medicine compound salvia miltiorrhiza preparation for treating cardiovascular and cerebrovascular diseases. Background technique [0002] Cardiovascular and cerebrovascular diseases are the first disease that causes human death. With the improvement of social living standards and the aging of the population, the research on drugs for cardiovascular and cerebrovascular diseases has become a hot spot in drug development. Coronary atherosclerotic heart disease, referred to as coronary heart disease, is caused by the deposition of some blood lipids such as cholesterol and triglycerides that cannot penetrate into the arterial wall to form "atheromatous plaque" on the intima of the artery. It makes the originally elastic arteries harden, and as the range of atherosclerotic plaques on the arterial intima increases, the b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10A61K31/045
Inventor 耿福能
Owner 耿福能
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