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Polyvinyl acetate mixed suspended liquid and preparation method and application thereof

A technology of polyvinyl acetate and vinyl acetate, which is applied in the field of polyvinyl acetate suspension and its preparation and application, can solve the problems of poor stability and high vinyl acetate monomer, and achieve good suspension and settlement performance , Low requirements for production equipment, good stability

Active Publication Date: 2009-12-16
SHANGHAI POLYMER PHARMA & EXCIPIENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The technical problem to be solved by the present invention is that the existing polyvinyl acetate emulsion has poor stability and the residual vinyl acetate monomer is too high and cannot be used as a pharmaceutical excipient, thereby providing a polyvinyl acetate suspension Liquid, with low impurity content, good stability and moderate solid content, which can meet the requirements of pharmaceutical excipients

Method used

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  • Polyvinyl acetate mixed suspended liquid and preparation method and application thereof
  • Polyvinyl acetate mixed suspended liquid and preparation method and application thereof
  • Polyvinyl acetate mixed suspended liquid and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043]

[0044]

[0045] Add the stabilizer and water into the reactor which is pre-filled with nitrogen and equipped with stirrer, reflux condenser and thermometer, and dissolve it. Add 20% of the vinyl acetate, start stirring, heat the thermostat, and control the reaction temperature at 70°C. Take the initiator, add 1 / 3 of its mass into the reactor, add the remaining 80% of vinyl acetate and the remaining 2 / 3 of the initiator dropwise after starting the reaction, and finish the drop within 3 hours. Continue to react for about 3 hours until there is no reflux. After the material was cooled to 50° C., 1% sodium bicarbonate solution was added to adjust the pH of the material to 5. Obtain a white opaque emulsion, adjust the solid content of the material to about 30% with purified water, and obtain a medicinal polyvinyl acetate suspension.

[0046] The content of each component of the polyvinyl acetate suspension is as follows:

[0047]

Embodiment 2

[0049]

[0050]

[0051] After adding stabilizer and water into a reactor filled with nitrogen in advance and equipped with a stirrer, reflux condenser and thermometer, dissolve it. Add 40% of the vinyl acetate, start stirring, heat the thermostat, and control the reaction temperature at 65°C. Take the initiator, add 2 / 5 of its mass into the reactor, add the remaining 60% of vinyl acetate and the remaining 3 / 5 of the initiator dropwise after starting the reaction, and finish dropping within 3 hours. Continue to react for about 3 hours until there is no reflux. After the material was cooled to 50° C., 1% sodium bicarbonate solution was added to adjust the pH of the material to 4. Obtain a white opaque emulsion, adjust the solid content of the material to about 30% with purified water, and obtain a medicinal polyvinyl acetate suspension.

[0052] The content of each component of the polyvinyl acetate suspension is as follows:

[0053]

Embodiment 3

[0055]

[0056] After adding stabilizer and water into a reactor filled with nitrogen in advance and equipped with a stirrer, reflux condenser and thermometer, dissolve it. Add 28% of the vinyl acetate, start stirring, heat the thermostat, and control the reaction temperature at 75°C. Take the initiator, add 1 / 3 of its mass into the reactor, add the remaining 72% of vinyl acetate and the remaining 2 / 3 of the initiator dropwise after starting the reaction, and finish the drop within 3 hours. Continue to react for about 3 hours until there is no reflux. After the material was cooled to 50° C., 1% sodium bicarbonate solution was added to adjust the pH of the material to 6. Obtain a white opaque emulsion, adjust the solid content of the material to about 30% with purified water, and obtain a medicinal polyvinyl acetate suspension.

[0057] The content of each component of the polyvinyl acetate suspension is as follows:

[0058]

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Abstract

The invention discloses polyvinyl acetate mixed suspended liquid, including 5 to 50 percent of polyvinyl acetate, 1 to 20 percent of stabilizing agent and 30 to 94 percent of water according to mass percentage, wherein the stabilizing agent includes surface active agent and water soluble high molecular materials. The invention also relates to a method for preparing the polyvinyl acetate mixed suspended liquid and the application of the polyvinyl acetate mixed suspended liquid used as pharmaceutic adjuvant in pharmaceutic preparations. The polyvinyl acetate mixed suspended liquid of the invention has low impurity content, favorable stability, good performance of mixed suspension and sedimentation and moderate solids content, the polyvinyl acetate mixed suspended liquid used as the pharmaceutic adjuvant can increase the capability of releasing controlled release medicines, and by different usage amount, the amount of the medicines which is designed to be released can be achieved within set time; and the degree of tolerance of a prepared particle coating is favorable, and the invention has low requirement on production equipment and is simple to operate.

Description

technical field [0001] The invention relates to a polyvinyl acetate suspension and its preparation method and application. Background technique [0002] Polyvinyl acetate emulsion is usually obtained by emulsion polymerization of vinyl acetate. Among them, vinyl acetate (Vinyl Acetate, VAc) is a colorless liquid, which is mainly synthesized industrially from ethylene and acetic acid. Its structure is as formula I: [0003] [0004] Formula I [0005] Polyvinyl acetate emulsion, because of its unique bonding properties and good film-forming properties, is currently used as an adhesive for bonding wood, bricks and tiles and architectural coatings in the market. [0006] The method for preparing polyvinyl acetate emulsion is mainly to polymerize monomer vinyl acetate emulsion in the presence of water, protective colloid polyvinyl alcohol (PVA), emulsifier and initiator, which is divided into one-time feeding method and semi-continuous seeding method. Emulsion polymerizat...

Claims

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Application Information

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IPC IPC(8): C08L31/04C08L39/06C08L29/04C08L1/02C08L1/08C08L71/00C08K5/10C08K5/42C08F118/08A61K47/32
Inventor 王懋杨学成
Owner SHANGHAI POLYMER PHARMA & EXCIPIENT
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