Method for removing sodium sulfate and sodium chloride from lauryl sodium sulfate

A technology of sodium chloride and sodium sulfate, which is applied in the field of pharmaceutical adjuvant production, can solve the problems of high content of sodium sulfate and sodium chloride, and achieve the effect of reducing the content

Active Publication Date: 2009-12-23
HUNAN ER KANG PHARMA
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Problems solved by technology

[0005] The present invention therefore proposes a method for removing sodium sulfate and sodium chloride impurities from technical grade s

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  • Method for removing sodium sulfate and sodium chloride from lauryl sodium sulfate
  • Method for removing sodium sulfate and sodium chloride from lauryl sodium sulfate

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[0023] Example

[0024] 35g technical grade SDS was dissolved in 70g ethanol-water solvent containing 30% ethanol. Stir for 30 min and filter to remove insolubles. The solution was lowered to 0-1 °C over a period of 3 hours and held for 30 min. The powder was obtained by filtration. The powder was combined with the above insoluble matter, dried and weighed to obtain 3.2 g. Burn the powder with no weight loss. The filtrate was concentrated under reduced pressure until the filtrate became a slurry. Finally, it was dried to remove water in a vacuum drying oven at 80° C. to obtain 30.7 g of the finished product. The sodium sulfate content was 2.1% and the sodium chloride content was 1.1%.

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Abstract

The invention relates to a method for obtaining pharmaceutical-grade lauryl sodium sulfate from industrial-grade lauryl sodium sulfate, which comprises the following steps of: (a) dissolving crude SDS into an ethanol-water solvent with ethanol content within 15-35 percent to prepare solution; (b) cooling the solution to 0-5 DEG C; (c) filtering the solution; and (d) concentrating the obtained solution so as to remove all solvents. The method utilizes the adverse impact on the solubility of SDS, sodium sulfate and sodium chloride due to the existence of ethanol, and can effectively remove sodium sulfate and sodium chloride impurities contained in the SDS and reduce the content of electrolyte impurities compared with the prior art.

Description

technical field [0001] The invention relates to the field of pharmaceutical auxiliary production, in particular to a purification method of sodium lauryl sulfate. Background technique [0002] Sodium dodecyl sulfate (SDS), as a typical anionic surfactant, has the effects of emulsification, decontamination, dispersion, wetting and foaming, and is widely used as an emulsifier, detergent, dispersant, Wetting agent, foaming agent, used to make tablets, granules, capsules, creams, medicinal shampoos, skin cleansers, etc. The impurities contained are usually homologues of lauryl sulfate, unreacted alcohol and electrolytes (such as sodium sulfate, sodium chloride). Current pharmaceutical grade SDS contains up to 8% sulfuric acid and up to 4% sodium chloride. The presence of these electrolytes will greatly reduce the critical micelle concentration c.m.c of SDS, and increase the aggregation number of micelles, making the micelles larger. [0003] Removing sodium sulfate and sodium...

Claims

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Application Information

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IPC IPC(8): C07C305/04C07C303/44C07C303/24
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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