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Preparation method of walnut green husk total tannin and application of same to antineoplastic medicines

A technology of walnut green husk and tannin, which is applied in the field of preparation of walnut green husk total tannin, can solve the problems that the research and development of anti-tumor active ingredients of walnut green husk total tannin are still blank, and achieve low production cost, high yield, high color shallow effect

Inactive Publication Date: 2010-01-06
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, although there are sporadic reports on the anti-tumor activity of walnut green peel, the research and development of anti-tumor active ingredients of walnut green peel total tannins is still blank

Method used

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  • Preparation method of walnut green husk total tannin and application of same to antineoplastic medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of the total tannin of embodiment 1 Yangbi soaked walnut tree walnut green husk

[0021] (1) Take 3.0kg of Yangbi walnut tree (Juglans sigillata Dode, also known as three Taiwan bubble walnut, iron walnut, deep texture bubble walnut, tea bubble walnut, etc.) walnut green peel as raw material, after drying and crushing, the mass ratio is 1 : 4 add 95% ethanol solution, extract 3 times with normal pressure reflux extraction device, each time for 72h, filter, and the filtrate is concentrated under reduced pressure to 5% of the original volume to obtain a crude extract;

[0022] (2) Add water with 3 times the mass of the crude extract, stir, add 3 times the mass of the crude extract with n-hexane for extraction, extract 4 times, separate, add dichloromethane with 3 times the mass of the crude extract to the remaining phase of the normal hexane extraction Methane extraction, extraction 3 times, separation, adding ethyl acetate with 3 times the mass of the cru...

Embodiment 2

[0024] The preparation of embodiment 2 wild walnut tree walnut green husk total tannins

[0025] (1) With dry, pulverized 4.0kg wild walnut tree (Juglans cathayensis Dode, another name Pakistani walnut, hickory nut etc.) walnut green skin is raw material, each with 10kg 80% ethanol water ultrasonic extraction 2 times, each 1h, filter, The filtrate was concentrated under reduced pressure to 2% of the original volume to obtain a crude extract;

[0026] (2) Add 2 times the water of the crude extract quality, stir, add 2 times the crude extract quality of n-hexane for extraction, extract 4 times, separate, add 2 times the crude extract quality of dichloride to the remaining phase of the normal hexane extraction Methane extraction, extraction 4 times, separation, adding ethyl acetate twice the mass of the crude extract to the remaining phase of dichloromethane extraction, extraction 4 times, separating the ethyl acetate extraction phase and the final water phase;

[0027] (3) Conc...

Embodiment 3

[0028] The preparation of embodiment 3 walnut catalpa walnut green husk total tannins

[0029] (1) With 5.0kg of dry, pulverized walnut green bark (Juglans mandshurica Maxim, having another name called Juglans mandshurica Maxim, etc.) as raw material, it is 1: 20 by mass ratio to add the ethanol aqueous solution that volume percent concentration is 70%, heat 35 Extract at ~40°C for 5 times, each time for 24 hours, filter, and concentrate the filtrate to 10% of the original volume under reduced pressure to obtain a crude extract;

[0030] (2) Add water with 4 times the mass of the crude extract, stir, add 6 times the mass of the crude extract with n-hexane for extraction, extract 2 times, separate, add dichloromethane with 6 times the mass of the crude extract to the remaining phase of the normal hexane extraction Methane extraction, extraction 2 times, separation, adding ethyl acetate with 6 times the mass of the crude extract to the remaining phase of dichloromethane extracti...

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Abstract

The invention belongs to the technical field of natural medicines, in particular to a preparation method of a walnut green husk total tannin and an application of the same in antineoplastic medicines. The walnut green husk total tannin is prepared by using walnut green husk as raw material and extracting, leaching, precipitating, separating and purifying the raw material, has light color and high purity, and the preparation method has the advantages of high yield, low production cost and simple and standard process. The walnut green husk total tannin prepared by the invention can remarkably inhibit the growth of tumor cells and can be used for preparing the antineoplastic medicines.

Description

technical field [0001] The invention belongs to the technical field of natural medicines, and in particular relates to a method and application for preparing total tannins from walnut green husks as raw materials. Background technique [0002] Malignant tumor is a common disease that seriously threatens human health. Among the urban population in my country, tumor is the first cause of death, accounting for 1 / 4 of all mortality. Tumor is also a major problem in today's medical field. Among the three major therapies for malignant tumors, drug therapy occupies an important position and is developing the fastest. The vast majority of synthetic chemical anti-tumor drugs use natural anti-cancer active ingredients as lead compounds. The development of anti-cancer drugs includes Both computer simulation and biomimetic design are based on natural anticancer active ingredients. In order to cope with the huge threat cancer poses to human health, scientists in the development of malig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A61P35/00A61K131/00
Inventor 司传领朱振元刘忠刘鹏涛惠岚峰
Owner TIANJIN UNIV OF SCI & TECH
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