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Polytetrafluorethylene/fluoroelastomer composite artificial bile duct and preparation thereof

A technology of polytetrafluoroethylene and artificial bile duct, which is applied in the field of composite artificial bile duct and its preparation, can solve the problems of few similar or similar patent reports, inconvenient suturing of hard materials, and low bile flow resistance, etc., and achieve good clinical operation performance , suitable for large-scale production, good biocompatibility effect

Inactive Publication Date: 2013-04-03
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the friction coefficient of the polyurethane surface is relatively large, and it is difficult to meet the requirement of small bile flow resistance.
Generally speaking, polymer soft materials have problems of cholestasis and leakage, while hard materials are not easy to suture
The artificial bile ducts currently developed mainly have a simple straight tube structure [Huang Huaxin, Wang Chen, Pei Fangjun, etc. Experimental research on the replacement of the common bile duct with silk artificial bile duct. Journal of Lanzhou Medical College, 1999, 20(1): 36-38 .] and balloon-type bile duct prosthesis [Xu Jianheng, balloon-type artificial bile duct (CN2242677)] two types: the simple straight-tube type bile duct can restore the continuity of the biliary tract, but its disadvantages are short-term cholestasis obstruction and retrograde infection; the balloon-type bile duct Prosthesis research can solve the problem of cholestasis, but the design is cumbersome and lacks clinical practical value
Therefore, no artificial bile duct has been really applied clinically.
[0006] PTFE materials have been proved by experiments to be used in artificial blood vessels, artificial lungs, artificial valves, artificial ears, and facial plastic surgery [K L Vidur. Medical polymer materials. International Textile Herald, 2005, 2: 75-78; Huang Jinghuan, Ding Jiandong. Biomedical polymer materials and modern medicine. China Medical Device Information, 2004, 10(4): 1-5.], its histocompatibility has been fully confirmed, but there is no domestic patent report using fluorine rubber coated polymer Preparation of artificial bile duct by tetrafluoroethylene, there are few domestic and foreign reports of similar or similar patents

Method used

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  • Polytetrafluorethylene/fluoroelastomer composite artificial bile duct and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take a polytetrafluoroethylene film with a thickness of 0.02 mm, wind it longitudinally on a glass rod with an inner diameter of 3 mm, and have a wall thickness of 0.02 mm; place it in a constant temperature oven at 250°C for 30 minutes, take it out and cool it; After the naphthalene-sodium tetrahydrofuran treatment solution is surface-treated for 5 seconds, it is cleaned and dried; the fluororubber-acetone solution (the mass ratio of fluororubber to acetone is 1:30) is coated on the surface-dried 3 times; then it is placed in 55 Heating in a vacuum oven at constant temperature for 30 minutes at ℃ to extract the residual acetone solvent; taking it out and cooling it to ambient temperature, sealing and packaging, sterilization and disinfection treatment, and the preparation of the artificial bile duct is completed. This material can be adapted for smaller size bile duct substitutes.

Embodiment 2

[0028] Take a polytetrafluoroethylene film with a thickness of 0.04 mm, wind it longitudinally on a glass rod with an inner diameter of 5 mm, and have a wall thickness of 0.04 mm; heat it in a constant temperature oven at 300°C for 20 minutes, take it out and cool it; After the naphthalene-sodium tetrahydrofuran treatment solution is surface-treated for 10 seconds, it is cleaned and dried; the fluororubber-acetone solution (the mass ratio of fluororubber to acetone is 1:25) is coated on the surface-dried 4 times; then it is placed in 55 Heating in a vacuum oven at constant temperature for 30 minutes at ℃ to extract the residual acetone solvent; taking it out and cooling it to ambient temperature, sealing and packaging, sterilization and disinfection treatment, and the preparation of the artificial bile duct is completed. This material is suitable for medium-sized bile duct substitutes.

Embodiment 3

[0030] Take a polytetrafluoroethylene film with a thickness of 0.06 mm, wind it longitudinally on a glass rod with an inner diameter of 6 mm, and have a wall thickness of 0.06 mm; place it in a constant temperature oven at 330°C for 15 minutes, take it out and cool it; After the naphthalene-sodium tetrahydrofuran treatment solution is surface-treated for 15 seconds, it is cleaned and dried; the fluororubber-acetone solution (the mass ratio of fluororubber to acetone is 1:20) is coated on the surface-dried 5 times; then it is placed in 55 Heating in a vacuum oven at constant temperature for 30 minutes at ℃ to extract the residual acetone solvent; taking it out and cooling it to ambient temperature, sealing and packaging, sterilizing and disinfecting, and the preparation of the artificial bile duct is completed. This material can be applied to larger models of bile duct substitutes.

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Abstract

The invention relates to a polytetrafluorethylene / fluoroelastomer composite artificial bile duct and preparation thereof. The polytetrafluorethylene / fluoroelastomer composite artificial bile duct is a composite flexible duct and sequentially comprises a polytetrafluorethylene membrane liner substrate, a naphthalene-sodium-tetrahydrofuran solution treating layer and a fluoroelastomer casting layerfrom inside to outside. The preparation of the polytetrafluorethylene / fluoroelastomer composite artificial bile duct comprises the following steps: heating polytetrafluorethylene membranes at constant temperature until generating bonding to form a polytetrafluorethylene membrane liner; treating the external surface of the polytetrafluorethylene membrane liner for 2 to 30 seconds by a naphthalene-sodium-tetrahydrofuran solution; then applying a fluoroelastomer acetone solution for 1 to 10 times to the external surface of the polytetrafluorethylene membrane liner; and finally drying, packaging and sterilizing the polytetrafluorethylene membrane liner. The polytetrafluorethylene / fluoroelastomer composite artificial bile duct has good biocompatibility, convenience for clinical application, durability, good mechanical strength, high safety, simple structure, convenient operation, simple preparation method, low cost and no environment pollution and can be used as a substitute for the bile duct, thereby being suitable for large scale production.

Description

technical field [0001] The invention belongs to the field of composite artificial bile duct and its preparation, in particular to a polytetrafluoroethylene / fluorine rubber composite artificial bile duct and its preparation. Background technique [0002] In medicine, the repair or reconstruction of the biliary tract after resection of the diseased common bile duct has always been one of the main problems in biliary surgery. Diseases of the biliary system often require resection or incision of the bile duct and various forms of biliary-enterostomy, which will result in loss of function or even structural loss of the bile duct and sphincter of Oddi, making the operation difficult and difficult to deal with due to the low regenerative capacity of the bile duct tissue after injury , postoperative prone to various complications. With the development and renewal of medical polymer materials, biological tissue substitutes have gradually entered clinical applications. [0003] Comp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61F2/04A61L27/16A61L27/18
Inventor 杨庆史同娜郯志清沈新元章悦庭
Owner DONGHUA UNIV