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Ferrous fumarate and folic acid pharmaceutical composition and liposome solid preparation thereof

A technology of ferrous fumarate and solid preparation, applied in the field of medicine, can solve problems such as failure to produce stable release, protective measures of folic acid and ferrous fumarate, etc., to prevent iron and folic acid deficiency during pregnancy, and to facilitate clinical The effect of medication and improving the therapeutic index of medication

Inactive Publication Date: 2010-01-27
HAINAN YONGTIAN PHARMA INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Those skilled in the art should clearly realize that it is only directly filled with ordinary capsules after adding ordinary excipients, and no protective measures are provided for folic acid and ferrous fumarate. After entering the body, the stable Release and other technical effects

Method used

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  • Ferrous fumarate and folic acid pharmaceutical composition and liposome solid preparation thereof
  • Ferrous fumarate and folic acid pharmaceutical composition and liposome solid preparation thereof
  • Ferrous fumarate and folic acid pharmaceutical composition and liposome solid preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The preparation of the liposome of embodiment 1 ferrous fumarate folic acid pharmaceutical composition

[0052] prescription:

[0053] Ferrous Fumarate 22g

[0054] Folic acid 0.35g

[0055] Hydrogenated Soy Lecithin 50g

[0056] Cholesterol 13g

[0057] Polyglycerides 18g

[0058] Poloxamer 188 30g

[0059] Preparation Process

[0060] (1) Dissolve 50g of hydrogenated soybean lecithin, 13g of cholesterol, 18g of polyglycerol ester and 30g of poloxamer 188 in 1000ml of n-butanol, mix well, remove n-butanol under reduced pressure on a rotary thin film evaporator, and obtain Phospholipid membrane;

[0061] (2) Add 500ml of phosphoric acid-sodium dihydrogen phosphate buffer solution with pH = 4.5, stir to completely hydrate the phospholipid membrane, then use a tissue masher to homogeneously emulsify for 20min at a speed of 13000r / min to prepare a blank liposome suspension liquid; (wherein, 22g ferrous fumarate is 22 parts, buffer solution 500ml is 500g is 500 par...

Embodiment 2

[0080] Example 2 Preparation of liposome of ferrous fumarate folic acid pharmaceutical composition

[0081] prescription:

[0082] Ferrous Fumarate 22g

[0083] Folic acid 0.35g

[0084] Hydrogenated Soy Lecithin 80g

[0085] Cholesterol 20g

[0086] Polyglycerol ester 12g

[0087] Poloxamer 188 44g

[0088] Preparation Process

[0089] (1) Dissolve 80g hydrogenated soybean lecithin, 20g cholesterol, 12g polyglycerol ester and 44g poloxamer 188 in 1500ml n-butanol, mix well, remove n-butanol under reduced pressure on a rotary thin film evaporator, and obtain Phospholipid membrane;

[0090] (2) Add 800ml of citric acid-sodium citrate buffer solution with pH=5.5, stir to completely hydrate the phospholipid membrane, and then homogenize and emulsify for 15min with a tissue masher at a speed of 15000r / min to prepare blank liposomes suspension;

[0091] (3) Evenly disperse 22g of ferrous fumarate and 0.35g of folic acid in 300ml of water, add it to the blank liposome s...

Embodiment 3

[0093] Example 3 Preparation of tablet of ferrous fumarate folic acid pharmaceutical composition

[0094] Select ferrous fumarate folic acid medicine 22.35g of embodiment 1 (containing ferrous fumarate 22g, the liposome 0.35g of folic acid composition)

[0095] Starch 52g

[0096] Lactose 46g

[0097] Carboxymethyl starch sodium 8g

[0098] Povidone K30 2.5g

[0099]Magnesium Stearate 1.5g

[0100] Preparation Process

[0101] (1) The liposomes containing 22.35g ferrous fumarate folic acid pharmaceutical composition prepared by embodiment 1 are pulverized, cross 80 mesh sieves, and set aside;

[0102] (2) Take by weighing 52g starch, 46g lactose, 8g sodium starch glycolate, cross 80 mesh sieves, mix, and set aside;

[0103] (3) Mix the above-mentioned raw and auxiliary materials evenly, add 50ml of 5% povidone K3080% ethanol solution to make soft material, pass through a 20-mesh sieve to granulate, dry at 60°C, and granulate with a 18-mesh sieve;

[0104] (4) Compre...

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PUM

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Abstract

The invention relates to a ferrous fumarate and folic acid pharmaceutical composition, a liposome solid preparation and a preparation method thereof. The solid preparation contains a liposome of the ferrous fumarate and folic acid pharmaceutical composition, and a pharmaceutically acceptable excipient, and specifically contains 1 part of the liposome of the ferrous fumarate and folic acid pharmaceutical composition, 0.2-1.5 parts of a filling agent, 0.01-0.5 parts of a disintegrant, 0.01-0.2 parts of an adhesive and 0.01-0.3 parts of a lubricant.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing ferrous fumarate and folic acid, a liposome solid preparation and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] According to the WHO report, the prevalence of anemia in Asian pregnant women is 40%. Domestic data show that the incidence of anemia during pregnancy is over 30%. Anemia in pregnancy is most common with iron deficiency anemia, accounting for about 68%. The detection data of serum ferritin, folic acid and VitB12 content during pregnancy showed that the content of serum ferritin and folic acid decreased with the increase of pregnancy. [0003] The commonly used blood enriching agent is ferrous sulfate. Ferrous fumarate, like ferrous sulfate, is a divalent iron preparation. Compared with ferrous sulfate, it has significant characteristics. Ferrous fumarate is orange-red or brown powder, slightly soluble in water, that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61K31/194A61K9/127A61K9/00A61K9/20A61J3/10A61P7/06
Inventor 王明
Owner HAINAN YONGTIAN PHARMA INST
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