Wild buckwheat rhizome polyphenol extract and preparation method thereof

A technology of extract and golden buckwheat, applied in the direction of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of reducing drug efficacy, high production cost, loss of activity, etc., and achieve low production cost, high recovery rate, and easy content Effect

Active Publication Date: 2010-01-27
曲靖市第一人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above three methods have their own characteristics, but there are some difficulties in applying the above three methods to industrial production. The ethanol extraction method extracts the polyphenol extract of golden buckwheat, which has high production cost, large energy consumption, and low ethanol recovery rate; and acetone extracts the organic solvent Extraction method and ethanol extraction inorganic salt saturated organic solvent extraction method have great defects in industrial production, high production cost, great environmental pollution, and difficult to control organic residues
Moreover, the ...

Method used

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  • Wild buckwheat rhizome polyphenol extract and preparation method thereof
  • Wild buckwheat rhizome polyphenol extract and preparation method thereof
  • Wild buckwheat rhizome polyphenol extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Take 100kg of golden buckwheat medicinal material coarse powder, put it in a dynamic multifunctional extraction tank with a stirring system, add 60% ethanol with 8 times the amount of medicinal material, dynamically percolate at 50°C-60°C, and stir and extract for 2 hours. Collect the extract, filter, vacuum degree 0.05Mpa, recover ethanol under reduced pressure, so that every 1ml extract contains 1.3g medicinal material; pass the obtained extract through pre-treated LAS-20 macroporous adsorption resin, and then use distilled water and 60% ethanol elution. Discard the water eluate, collect 60% ethanol eluate, vacuum 0.05Mpa, recover ethanol at 50°C-60°C, concentrate to extract, and microwave dry to obtain brown-red amorphous powder. The yield was 12.8%.

Embodiment 2

[0067] The identification of embodiment 2 golden buckwheat polyphenol extract

[0068] The instrument used in this experiment is Agilent-1100 high performance liquid chromatography (including G1379A online degasser, G1311A quaternary pump, G1313A autosampler, G1316A column thermostat, G1314A variable wavelength detector, Agilent chemical workstation) , the chromatographic column used is Zorbax XDB-C18 pre-column (4.6×12.5mm), Zorbax EclipseXDB-C18 chromatographic column (5um, 4.6mm×250mm); mobile phase is water (adjust the pH value to 3.00±0.02 with phosphoric acid) - Acetonitrile (92:8), the detector is a VWD detector, the detection wavelength is 280nm, and the column temperature is 35°C.

[0069] Get each 2g of the standard substance (National Institute for the Control of Pharmaceutical and Biological Products) of epicatechin and proanthocyanidin B2 and the coarse powder sample of golden buckwheat reference medicinal material, and process and prepare the sample liquid in the...

Embodiment 3

[0077] Tablets for treating acute bronchitis are prepared with the following formulation.

[0078] Golden Buckwheat Polyphenol Extract 200g

[0079] Sodium carboxymethyl starch appropriate amount

[0080] Appropriate amount of sodium pregelatinized starch

[0081] Proper amount of ethanol

[0082] Magnesium Stearate Appropriate amount

[0083] [Preparation method] Mix golden buckwheat extract, sodium hydroxymethyl starch and sodium pregelatinized starch evenly and pass through a 100-mesh sieve, then use ethanol to make a soft material, dry at 70-80°C, and pass through a 14-mesh sieve Sorting, adding magnesium stearate and mixing evenly, pressing into 1000 pieces with a 10mm die to obtain the final product.

[0084] [Functions and Indications] Quxie and strengthening the body, clearing heat and detoxification, promoting blood circulation and removing blood stasis, eliminating blood stasis and resolving stagnation, antitussive and expectorant. It is used for cough, chronic ...

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Abstract

The invention relates to a wild buckwheat rhizome polyphenol extract, a preparation method thereof, an identification method thereof and application thereof. The preparation method comprises the following steps: coarsely extracting wild buckwheat rhizome by adopting a low-temperature stirring dynamic percolation method; then refining the course extract by using neutral macroporous adsorption resin; and finally, drying the refined extract with microwave at the low temperature to obtain the wild buckwheat rhizome polyphenol extract with free organic substance residues, high activity and high purity. The wild buckwheat rhizome polyphenol extract can be widely used for treating various diseases, and particularly can be used together with other Chinese medicament to enhance the treatment effect. The technical characteristics of the wild buckwheat rhizome polyphenol extract are described by applying digitalized chromatographic fingerprint technology, the content and quality of the effective components of the wild buckwheat rhizome polyphenol extract can be quantitatively judged by measuring the fingerprints of a sample by adopting a liquid chromatography method.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to a golden buckwheat polyphenol extract and a preparation method thereof, as well as identification and application of the golden buckwheat polyphenol extract. Background technique [0002] Golden buckwheat (Fagopyrum Cymosum (Trev) Meisn) belongs to the genus Poygonum of the family Polygonaceae, also known as wild buckwheat, sky buckwheat, red notoginseng, and is the most widely wild species of buckwheat in my country. It is distributed in Daba Mountain in China south to southern China. Golden buckwheat tastes slightly pungent, astringent, cool, and returns to the lung meridian. It has the effects of clearing heat and detoxifying, draining pus and removing blood stasis, anticancer and antibacterial, and is used for the treatment of lung abscess, measles pneumonia, peritonsillar abscess and other diseases. [0003] Golden buckwheat polyphenol (proanthocyanidin) extract is ...

Claims

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Application Information

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IPC IPC(8): A61K36/70A61K36/896A61K9/48A61K9/20A61K9/16A61K9/06A61K9/10A61K9/14A61K9/00G01N31/02A61P31/12A61P29/00A61P11/00A61P17/00A61P31/04A61K35/50A61K33/06A61K31/422A61K31/4375A61K31/4164A61K125/00
Inventor 袁建平
Owner 曲靖市第一人民医院
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