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Organic/inorganic nano hybridized hydrogel for tooth root canal filling material

A filling material, inorganic nanotechnology, applied in dentistry, dental preparations, dental prostheses, etc., can solve the problems of coronal leakage and root canal treatment failure, improve the mechanical properties of gel, eliminate micro-gap and coronal Leakage phenomenon, the effect of easy inspection

Active Publication Date: 2010-02-17
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional root canal filling materials are composed of gutta-percha tips and paste. Due to the existence of polymerization shrinkage, gaps or coronal leakage often appear between the filling material and the root canal wall, resulting in the failure of root canal treatment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Add 200ml of a mixture of ethanol and deionized water (volume ratio 95:5) into the three-neck flask to adjust the pH to 3-4, then add 50g of silane coupling agent A174, and hydrolyze for 3 hours at room temperature. 10 g of inorganic nanoparticles (ZnO:ZrO 2 =50:1) was dispersed in 200ml of deionized water, added to a three-neck flask, ultrasonicated at 70°C for 1 hour, then slowly added dropwise 5g of the silane coupling agent solution prepared in the above hydrolysis within 30 minutes, and then adjusted the pH value of the solution to 9 -11, continue to react for 3 hours under ultrasonic conditions at 70°C. After the modification, ethanol solution is used to elute the unreacted silane coupling agent, and the modified inorganic nano antibacterial powder is obtained after drying. Take 0.1g of the modified inorganic nanopowder, disperse it into 10ml of deionized water, stir well, add 0.5g of N-isopropylacrylamide, pass N 2 After 30 minutes, add 0.01g of N,N'-methyleneb...

Embodiment 2

[0025] Add 200ml of a mixture of ethanol and deionized water (volume ratio 95:5) into the three-neck flask to adjust the pH to 3-4, then add 50g of silane coupling agent A151, and hydrolyze for 3 hours at room temperature. 10 g of inorganic nanoparticles (ZnO:ZrO 2 =50:1) was dispersed in 200ml of deionized water, added to a three-necked flask, ultrasonicated at 70°C for 1 hour, then slowly added dropwise 5g of the silane coupling agent solution prepared in the above hydrolysis step within 30 minutes, and then the pH value of the solution was adjusted to 9-11, the reaction was continued for 3 hours under ultrasonic conditions at 70°C. After the modification, ethanol solution is used to elute the unreacted silane coupling agent, and the modified inorganic nano antibacterial powder is obtained after drying. Take 0.1g of the modified inorganic nanopowder, disperse it into 10ml of deionized water, stir well, add 2g of N-isopropylacrylamide, pass N 2 After 30 minutes, add 0.02g ...

Embodiment 3

[0027] Add 200ml of a mixture of ethanol and deionized water (volume ratio 95:5) into the three-neck flask to adjust the pH to 3-4, then add 50g of silane coupling agent A174, and hydrolyze for 3 hours at room temperature. 10 g of inorganic nanoparticles (ZnO:ZrO 2 =80:1) was dispersed in 200ml of deionized water, added to a three-necked flask, ultrasonicated for 1 hour at 70°C, and then slowly added dropwise within 30 minutes 5 g of the silane coupling agent solution prepared in the above hydrolysis step, and then the pH value of the solution was adjusted to 9-11, the reaction was continued for 3 hours under ultrasonic conditions at 70°C. After the modification, ethanol solution is used to elute the unreacted silane coupling agent, and the modified inorganic nano antibacterial powder is obtained after drying. Take 1g of the modified inorganic nanopowder, disperse it into 10ml of deionized water, stir well and add 0.5g of N-methylolacrylamide, pass N 2 After 30 minutes, add ...

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Abstract

The invention relates to a nano hybridized hydrogel which can be used as a tooth root canal filling material. The organic / inorganic nano hybridized hydrogel for the tooth root canal filling material is formed by polymerizing a silane coupling agent modified inorganic nano particle, a monomer, an initiating agent and a cross-linking agent, wherein the inorganic nano particle is a mixed nano particle of ZnO and ZrO2; and the monomer is an amide or ester water-soluble organic compound. The organic / inorganic nano hybridized hydrogel has specific swelling performance, favorable biocompatibility, excellent stability and favorable service behaviour, no toxic and side effect and durable antibiosis and can thoroughly eliminate phenomena of microgaps and coronal leakage of the traditional root canalmaterial caused by polymerization shrinkage, be convenient to disinfect, use and remove and achieve X-ray radiation resistance so as to be convenient for examination. In addition, compared with the traditional gel material, the gel is greatly improved on mechanical performance and has high application value.

Description

technical field [0001] The invention relates to a high molecular polymer, in particular to a nano-hybrid hydrogel which can be used as a root canal filling material. Background technique [0002] Oral diseases, as common and frequently-occurring diseases, seriously affect human health. Among them, the incidence rate of caries is as high as 80%. Together with cardiovascular and cerebrovascular diseases and tumors, it is listed by the World Health Organization as the three major non-communicable diseases that need to be prevented and controlled in the 21st century. In my country, more than 1 billion people suffer from caries. More than 600 million patients must be treated. Pulp disease and periapical disease are easily caused by caries, and the incidence rate remains high, which has caused great harm to human health. Root canal therapy is the only effective way to treat endodontic and periapical diseases. By cleaning and disinfecting the root canal and filling it tightly with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/083
Inventor 朱美芳武永涛范青青周哲张青红俞昊
Owner DONGHUA UNIV
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