Crystalline form of hydrochlorothiazide and application thereof
A technology of hydrochlorothiazide and crystal form, which is applied in the field of medicinal chemistry, can solve the problems of slow dissolution of hydrochlorothiazide and poor production utilization, and achieve the effects of improving dissolution effect, solving slow dissolution speed and effective therapeutic effect
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Embodiment 1
[0039] Hydrochlorothiazide Tablets
[0040] components
quantity
Hydrochlorothiazide
25g
microcrystalline cellulose
60g
lactose
48.5g
Low-substituted hydroxypropyl cellulose
7g
povidone k30
8g
Micropowder silica gel
0.75g
Magnesium stearate
0.75g
[0041] Preparation method: sieve the raw and auxiliary materials for later use; take hydrochlorothiazide, microcrystalline cellulose, starch, mannitol, sodium carboxymethyl starch, and low-substituted hydroxypropyl cellulose and mix evenly; then add micronized silica gel and magnesium stearate Mix well; tablet that is.
[0042] The preparation method of hydrochlorothiazide is as follows: dissolve 100 g of hydrochlorothiazide in 500 ml of 4% sodium hydroxide aqueous solution, add dropwise 10% hydrochloric acid, precipitate hydrochlorothiazide crystals, suction filter, and dry the product to obtain hydrochlorothiazide cryst...
Embodiment 2
[0044] Valsartan Hydrochlorothiazide Tablets
[0045] components
quantity
Valsartan
80g
Hydrochlorothiazide
12.5g
starch
60g
microcrystalline cellulose
30g
Sodium carboxymethyl starch
10g
Magnesium stearate
1g
10% povidone k30
20ml
[0046] Preparation method: take valsartan, hydrochlorothiazide, starch, and microcrystalline cellulose and sieve separately for later use; the above-mentioned raw and auxiliary materials are mixed and mixed evenly when passing through a 100-mesh sieve; Granulate with a mesh sieve; dry the granules in a drying oven at 50°C; add sodium carboxymethyl starch and magnesium stearate to mix, pass through a 18-mesh sieve for granulation; compress into tablets; coat plain tablets to obtain the product.
[0047] The preparation method of hydrochlorothiazide is as follows: dissolve 100 g of hydrochlorothiazide in 250 ml of 5% sodium hydroxide aq...
Embodiment 3
[0049] Irbesartan Hydrochlorothiazide Capsules
[0050] components
quantity
Irbesartan
150g
Hydrochlorothiazide
12.5g
starch
30g
microcrystalline cellulose
40g
lactose
25g
Crospovidone
10g
Magnesium stearate
1.5g
5% povidone k30 aqueous solution
40ml
[0051] Preparation method: sieve each raw and auxiliary material for later use; take irbesartan, hydrochlorothiazide, starch, microcrystalline cellulose, lactose, and cross-linked povidone and mix evenly; add 5% povidone solution in the prescribed amount to make a soft material ; Sieve through a 40-mesh granulation; dry the granules in a drying oven at 50°C; add magnesium stearate to the dry granules, pass through a 30-mesh granule; pack the granules into capsules.
[0052] The preparation method of hydrochlorothiazide is as follows: dissolve 100 g of hydrochlorothiazide in 1000 ml of an aqueous solutio...
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