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Method for preparing liver cell growth promoter freeze-drying powder injection for injecting

A technology for hepatocyte growth hormone and freeze-dried powder injection, which is applied in the field of biological drug preparation, can solve the problems of high technical content requirements, complex operation process, long production cycle and the like, and achieves low technical content requirements, simple operation process, The effect of short production cycle

Active Publication Date: 2010-03-17
GUANGDONG LONGFU MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation methods of hepatocyte growth-promoting hormone injection powder in these prior art have problems such as long production cycle, low output, complex operation process and high technical content requirements.

Method used

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  • Method for preparing liver cell growth promoter freeze-drying powder injection for injecting
  • Method for preparing liver cell growth promoter freeze-drying powder injection for injecting
  • Method for preparing liver cell growth promoter freeze-drying powder injection for injecting

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0017] 1. Prescription:

[0018] Prescription 1:

[0019] Hepatocyte growth-stimulating hormone stock solution 200g

[0020] Mannitol 2400g

[0021] Add water for injection to 40000mL

[0022]

[0023] Makes 10000 bottles

[0024] Prescription 2:

[0025] Hepatocyte growth-stimulating hormone stock solution 400g

[0026] Mannitol 3200g

[0027] Add water for injection to 40000mL

[0028]

[0029] Makes 10000 bottles

[0030] Prescription 1:

[0031] Hepatocyte growth-stimulating hormone stock solution 600g

[0032] Mannitol 4000g

[0033] Add water for injection to 40000mL

[0034]

[0035] Makes 10000 bottles

[0036] 2. Preparation method:

[0037] Taking prescription 2 as an example, weigh 400g of hepatocyte growth-promoting hormone stock solution, thaw it into...

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Abstract

The invention relates to a method for preparing liver cell growth promoter freeze-drying powder injection for injecting. The preparation method comprises the following steps: weighing 10000 parts by volume of liver cell growth promoter solution and stirring evenly under an aseptic condition; adding a skeleton agent in the solution, regulating the pH value within the range of 6.0-7.0 and stabilizing the volume; sterilizing and filtering 2-3 times and collecting filtrate; and filling and freeze-drying. The freeze-drying time is sequentially as follows: 5 hours at the temperature of -40 DEG C, 6hours at the temperature of -40--15 DEG C, 3 hours at the temperature of -15--5 DEG C, 2 hours at the temperature of -5-5 DEG C, 4 hours at the temperature of 5-40 DEG C and 8.5 hours at the temperature of 40 DEG C, and the total freeze-drying time is 28.5 hours.

Description

technical field [0001] The invention relates to a preparation method of biological medicine, in particular to a preparation method of hepatocyte growth-promoting hormone freeze-dried powder for injection. Background technique [0002] For many years, researchers have been studying substances that can prevent liver cell necrosis and promote liver cell regeneration, and research in this field has focused on liver regeneration stimulating factors produced by the liver itself, among which hepatocyte growth-stimulating factor has been proved It has the effect of stimulating liver cell regeneration. [0003] Hepatocyte growth-stimulating hormone is a mixture of multi-component small molecular peptides extracted from fresh suckling pig liver or non-lactating newborn bovine liver, with a molecular weight below 10,000Da. Its main pharmacological effect is to significantly stimulate the DNA synthesis of new liver cells, improve the phagocytic function of liver Kupffer cells, have a g...

Claims

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Application Information

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IPC IPC(8): A61K38/02A61K35/407A61K9/19A61K47/10A61P1/16
Inventor 张隆鑫
Owner GUANGDONG LONGFU MEDICINE CO LTD
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