Medication and preparation method and application thereof

A technology for medicines and extracts is applied in the field of medicines using ginseng and Salvia miltiorrhiza as raw materials and their preparation, and can solve the problems of complicated operation, large consumption of ethanol, and reduced safety in industrialized production.

Active Publication Date: 2012-07-11
GUANGZHOU XIANGXUE PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

But there is following shortcoming in the method for extracting salvia miltiorrhiza above: 1, in the prepared salvia miltiorrhiza extract, the content of salvia miltiorrhiza is not high, and productive rate is lower, generally at 2~4%; 2, adopt high concentration The ethanol alcohol precipitation greatly reduces the safety of industrial production, the ethanol consumption is large, and the production cost is high; 3. The high-concentration ethanol alcohol precipitation step affects the yield of total salvianolic acid in the salvia miltiorrhiza extract; 4. A large amount of concentrated water is required , it is not convenient for industrialized large-scale production, and the operation is more complicated; 5. Generally, Danshensu and protocatechualdehyde are selected as index components to control the quality of Danshen preparations, but protocatechualdehyde has toxic side effects, and it is unreasonable to use Danshensu to represent the activity of Danshen

Method used

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  • Medication and preparation method and application thereof
  • Medication and preparation method and application thereof
  • Medication and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Embodiment 1, the preparation of the medicine for the treatment of cardiovascular disease

[0078] The medicament for treating cardiovascular disease of this embodiment is composed of ginseng extract and salvia miltiorrhiza extract, wherein, the preparation method of ginseng extract and salvia miltiorrhiza extract is as follows:

[0079] One, the preparation of ginseng extract

[0080]Get the root of ginseng (Panax.ginsengC.A.Mey) to pulverize and sieve to obtain 10 mesh ginseng coarse powder. Accurately weigh 10kg of ginseng coarse powder, add 80L of 90% ethanol by volume for reflux extraction, the extraction time is 45min; collect the extract, and then add 80L of 90% ethanol by volume to the residue for reflux Extraction, the extraction time is 45min; repeat the above extraction process once. Mix the three extracts, cool to room temperature, filter, take the filtrate and concentrate it under reduced pressure until it has no alcohol smell, and obtain 2.3kg of extract...

Embodiment 2

[0093] Embodiment 2, the preparation of the medicine for the treatment of cardiovascular disease

[0094] The preparation method of ginseng extract and salvia miltiorrhiza extract is the same as that in Example 1. Mix 200 g of the ginseng extract powder prepared according to the method in step 1 of the above example 1 with 20 g of the powder of the salvia miltiorrhiza extract prepared in accordance with the method in the step 2 of the above example 1 to obtain the medicine of the present invention.

Embodiment 3

[0095] Embodiment 3, the preparation of the medicine for the treatment of cardiovascular disease

[0096] The preparation method of ginseng extract and salvia miltiorrhiza extract is the same as that in Example 1. Mix 20 g of the ginseng extract powder prepared according to the method of step 1 of the above example 1 with 400 g of the powder of the salvia miltiorrhiza prepared according to the method of step 2 of the above example 1 to obtain the medicine of the present invention.

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Abstract

The present invention discloses a medication and a preparation method and application thereof Active components of the medication are ginseng extract and salvia miltiorrhiza extract; a weight ratio between the ginseng extract and the salvia miltiorrhiza extract is 1:(0.1-20); a weight percentage content of total ginsenoside in the ginseng extract is larger than 50%; and a weight percentage content of salvianolic acid in the salvia miltiorrhiza extract is larger than 50%. As shown in the result of Wistar rat myocardial infarction experiment and myocardial ischemia experiment, the reconstitution of total ginsenoside and salvianolic acid has an optimal therapeutic effect, can effectively control Wistar rat myocardial infarction area and improve myocardial ischemia situation, furthermore, has a same therapeutic effect with an original medicinal material reconstitution prescription. Pharmaceutical ingredient of the medication of the invention is clear and the quality of the medication can be controlled easily.

Description

technical field [0001] The invention relates to a medicine and its preparation method and application, in particular to a medicine using ginseng and salvia miltiorrhiza as raw materials, its preparation method and application. Background technique [0002] Cardiovascular and cerebrovascular diseases are a class of diseases that seriously endanger human health. With the increase of social pressure and the aging of my country's population, the incidence of cardiovascular diseases in my country remains high. Therefore, it is of great social significance to develop drugs for the treatment of cardiovascular diseases. [0003] Chinese herbal medicine ginseng is the root of Panax ginseng C.A. The roots of ginseng are sweet, slightly bitter, and warm in nature. Ginseng mainly contains components such as saponins, volatile oils (panaxynol, ginseng sesquiterpenes, sterols, fatty acids), sugars, amino acids, peptides and vitamins. 40 kinds of ginsenosides were isolated, namely ginse...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P9/10
Inventor 罗国安李连达王义明
Owner GUANGZHOU XIANGXUE PHARMA CO LTD
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