Preparation method of polylactic acid/chitosan/carbon fiber porous supports

A porous scaffold and carbon fiber technology, applied in medical science, prosthesis, etc., achieves high academic value and use value, is conducive to adhesion, and has the effect of large internal surface area
CN101693124AInactive Publication Date: 2010-04-14CHONGQING UNIV OF ARTS & SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHONGQING UNIV OF ARTS & SCI
Publication Date
2010-04-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of polylactic acid / chitosan / carbon fiber porous supports. The preparation method comprises the steps: weighing dispersed and well-dried carbon fiber and polylactic acid solution and ultrasonically oscillating and mixing the two so that the carbon fiber is dispersed in the polylactic acid solution; then mixing the two with a certain proportion of chitosan solution evenly; pouring the evenly mixed tertiary mixture in a support die; and putting the die in a freezing drier to be frozen quickly, preserved with heat, vacuumized and dried, and finally demolding and washing, thus obtaining a polylactic acid / chitosan / carbon fiber porous support. The developed compound porous support has the advantages of simple manufacture technology, good mechanical performance, highly porous property, favorable compatibility with cells and the like, and has wide application prospect in the medical field.
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Description

technical field

[0001] The invention belongs to the preparation technology of tissue engineering scaffold material, in particular, it is a preparation method of polylactic acid / chitosan / carbon fiber porous scaffold. Background technique

[0002] Human hard tissue defects caused by trauma, tumors, inflammation and the aging of society are difficult problems to be solved in clinical medicine. Polylactic acid (PLA) and chitosan (CS) have been widely used in surgical sutures, bone fixators and tissue engineering scaffold materials due to their good biocompatibility and biodegradability. Research hotspots of degradable materials. However, the acidity of the lactic acid produced in the early stage of PLA degradation is strong, and its local accumulation will have a certain stimulating effect on the tissue, causing inflammation, and the mechanical properties of PLA decrease very quickly during the degradation process; while the molecular structure of CS is similar to the amino aci...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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