Preparation method of polylactic acid/chitosan/carbon fiber porous supports

A porous scaffold and carbon fiber technology, applied in medical science, prosthesis, etc., achieves high academic value and use value, is conducive to adhesion, and has the effect of large internal surface area

Inactive Publication Date: 2010-04-14
CHONGQING UNIV OF ARTS & SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many researches on PLA and CS materials at home and abroad, but the research on blending and modifying the two materials by physical means, and using carbon fiber reinforcement to construct three-dimensional scaffold biomaterials for bone tissue repair has not been reported yet.

Method used

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  • Preparation method of polylactic acid/chitosan/carbon fiber porous supports
  • Preparation method of polylactic acid/chitosan/carbon fiber porous supports
  • Preparation method of polylactic acid/chitosan/carbon fiber porous supports

Examples

Experimental program
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Effect test

Embodiment 1

[0024] 1) Weigh 6.0001g of methylcellulose and add it to a flask filled with 400ml of deionized water, add about 1.2000g of carbon fiber, stir and disperse on a magnetic stirrer for 60min, filter the carbon fiber on a 200-mesh sieve and dry it for later use; weigh Dissolve 4.4001g of chitosan in 20mL of deionized water and set aside; weigh 7.9996g of polylactic acid and dissolve in 40mL of tetrahydrofuran for use.

[0025]2) Weigh 0.0100g of carbon fiber into 40mL of polylactic acid solution, and ultrasonically mix in an ultrasonic oscillator for 1.5h; add 5mL of chitosan solution, stir gently with a magnetic stirring speed of 100r / min for 0.5h, and then oscillate with ultrasonic waves for 4h ,; Pour the uniformly mixed ternary mixture into the bracket mold, put it into the freeze dryer and freeze it quickly to -55±2°C, freeze it at this temperature for 6 hours, and then keep the freezing temperature under vacuum at 15.6KPa to vacuumize 3h, and finally 5°C low-temperature dryi...

Embodiment 2

[0027] 1) Weigh 2.9981g of methylcellulose and add it to a flask filled with 200ml of deionized water, add about 0.4500g of carbon fiber, stir and disperse on a magnetic stirrer for 40min, filter the carbon fiber on a 200-mesh sieve and dry it for later use; weigh Dissolve 1.9998g chitosan in 10mL deionized water and set aside; weigh 6.0002g polylactic acid and dissolve it in 30mL carbon trichloride and set aside.

[0028] 2) Weigh 0.0080g carbon fiber and put it into 30mL polylactic acid solution, and ultrasonically mix it in an ultrasonic oscillator for 2h; add 3mL chitosan solution, mix and stir gently with a magnetic stirring speed of 150r / min for 1h, and then oscillate with ultrasonic wave for 3.5h, ; Pour the well-mixed ternary mixture into the bracket mold, put it into the freeze dryer and freeze it quickly to -58±2°C, freeze it at this temperature for 7.5 hours, and then keep the freezing temperature under vacuum at 17.0KPa to vacuumize After 2.5 hours, dry at 5°C for ...

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Abstract

The invention discloses a preparation method of polylactic acid/chitosan/carbon fiber porous supports. The preparation method comprises the steps: weighing dispersed and well-dried carbon fiber and polylactic acid solution and ultrasonically oscillating and mixing the two so that the carbon fiber is dispersed in the polylactic acid solution; then mixing the two with a certain proportion of chitosan solution evenly; pouring the evenly mixed tertiary mixture in a support die; and putting the die in a freezing drier to be frozen quickly, preserved with heat, vacuumized and dried, and finally demolding and washing, thus obtaining a polylactic acid/chitosan/carbon fiber porous support. The developed compound porous support has the advantages of simple manufacture technology, good mechanical performance, highly porous property, favorable compatibility with cells and the like, and has wide application prospect in the medical field.

Description

technical field [0001] The invention belongs to the preparation technology of tissue engineering scaffold material, in particular, it is a preparation method of polylactic acid / chitosan / carbon fiber porous scaffold. Background technique [0002] Human hard tissue defects caused by trauma, tumors, inflammation and the aging of society are difficult problems to be solved in clinical medicine. Polylactic acid (PLA) and chitosan (CS) have been widely used in surgical sutures, bone fixators and tissue engineering scaffold materials due to their good biocompatibility and biodegradability. Research hotspots of degradable materials. However, the acidity of the lactic acid produced in the early stage of PLA degradation is strong, and its local accumulation will have a certain stimulating effect on the tissue, causing inflammation, and the mechanical properties of PLA decrease very quickly during the degradation process; while the molecular structure of CS is similar to the amino aci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/56A61L27/58
Inventor 徐文峰廖晓玲
Owner CHONGQING UNIV OF ARTS & SCI
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