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Application of lipid active substance of theaceous plant in treating hormone-dependent dermatitis

A technology of dependent dermatitis and active substances, which is applied in the field of application of lipid active substances of Camellia plants in the treatment of hormone-dependent dermatitis, and can solve the problems of slow recovery of patients, thinning of the stratum corneum, and damage of the skin barrier, etc. problems, to achieve the effect of improving human health care and quality of life, facilitating the formation of wound epithelial cells, and reducing adverse stimuli

Inactive Publication Date: 2010-04-28
江西金海棠药用油有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, the pathogenesis of hormone-dependent dermatitis has not been fully clarified. It is currently believed that it may be related to skin atrophy caused by corticosteroids; Water, which inflames normal or diseased skin
[0006] At present, there is no effective treatment in Western medicine, and the main method is the "slow-stop method (substitution method)", which gradually reduces the strength and dosage of hormone drugs, and then cooperates with antibacterial, anti-inflammatory, and anti-allergic drug treatments until all hormone drugs are removed and the skin barrier function is restored. Eliminate local skin lesions; emphasize that the treatment principle of this disease is local protection and comfort, and more importantly, the self-renewal function of the skin
Therefore, the recovery of this program is slow, and it is difficult for most patients to accept this slow recovery process.

Method used

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  • Application of lipid active substance of theaceous plant in treating hormone-dependent dermatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Clinical observation of 30 cases of facial hormone-dependent dermatitis treated with lipid active substances

[0018] 1 Materials and methods

[0019] 1 Inclusion criteria

[0020] (1) There is a history of external use of hormone products on fixed sites for more than half a month;

[0021] (2) The original disease or skin lesion recurs or aggravates 2 to 10 days after stopping the use of hormone-containing products; hormone dependence occurs (rebound after stopping the drug, the original disease or skin lesion recurs or aggravates, and the symptoms are relieved after repeated use) );

[0022] (3) Typical skin lesions: diverse skin lesions with erythema, papules, dryness and desquamation as the basic lesions, which cannot be explained by other skin diseases;

[0023] (4) Subjective symptoms: conscious local itching, burning pain, tightness and swelling, or dry discomfort, which are aggravated by heat and relieved by cold.

[0024] Those who have (1), (2) ...

Embodiment 2

[0058] Example 2: Clinical Observation of 50 Cases of Facial Hormone-Dependent Dermatitis Treated by Lipid Actives

[0059] 1 Materials and methods

[0060] 1 Inclusion criteria are the same as in Example 1

[0061] 2 get rid of the case with embodiment 1

[0062] 3 General Information

[0063]A total of 100 patients, including 22 males and 78 females; aged 21 to 50 years old; had external use of betamethasone, clobetasone, etc., an average of 7.3 months (1 month to 12 years).

[0064] 100 patients were randomly divided into treatment group [50 cases, age (32.2±5.99) years] and control group [50 cases, age (31.82±7.52) years]. There was no significant difference between the treatment group and the control group in terms of age, sex, course of disease and symptom scores, and they were comparable.

[0065] 4 treatment methods

[0066] Treatment group: self-made lipid actives, made into light yellow oily liquid, enterprise standard, accelerated stability test results show th...

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Abstract

The invention relates to application of a lipid active substance of a theaceous plant in treating hormone-dependent dermatitis. A treatment method is to prepare the lipid active substance into an acceptable dosage form, an intestinal administration or local administration mode is adopted, and the lipid active substance has the efficacies of clearing heat and releasing toxin, dispelling wind and eliminating dampness, nourishing yin and cooling blood; the lipid active substance is locally smeared at least twice every day in external use, and the smearing amount is determined according to the skin area and the skin absorption condition; and the lipid active substance has the functions of backing red, dispersing swelling and relieving ache and itch, is also favorable for wound surface epithelial cell formation, granulation tissue growth and wound surface healing, can be used for preparing a product for preventing and treating the hormone-dependent dermatitis, provides a brand-new treatment scheme with exact treatment effect for patients, and also can make full use of natural resources and improve the human health-care level and the quality of life.

Description

technical field [0001] The invention relates to the application of lipid active substances from Camellia plants in preventing and treating hormone-dependent dermatitis. Background technique [0002] Since glucocorticoids have anti-allergic, anti-inflammatory, and anti-proliferative effects of inhibiting immune responses, they can reduce congestion and edema, reduce exudation and cell infiltration after external use, and temporarily relieve the degree of itching and inflammatory reactions of certain skin lesions. Relief and resolution. [0003] The doctor's inaccurate grasp of the indications for external use of hormone-containing products, or the inflammatory skin lesions caused by excessive external use of hormone-containing products by patients, this kind of skin lesions have varying degrees of dependence on hormones, because this dependence forces patients to use hormones for a long time It cannot be stopped, and the skin lesions will be aggravated and the condition will...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61P17/00A61K135/00A61K133/00A61K131/00A61K127/00A61K125/00
Inventor 范友灵朱少新万金梅
Owner 江西金海棠药用油有限公司
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