Chaotic microfluidic chip mixer and mixing method thereof
A microfluidic chip and micromixer technology, applied in mixing methods, fluid mixers, chemical instruments and methods, etc., can solve the problems of expensive microfabrication process, limited application, etc., to prevent laminar flow effect between solutions , The effect of simple processing and fast mixing speed
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Embodiment 1
[0017] The mixing principle schematic diagram of mixer of the present invention sees figure 1 .
[0018] Such as figure 2 As shown, a zigzag single microchannel 2 with a length of 40 cm, a width of 100 microns, and a depth of 10 microns is etched or hot-pressed on the first substrate 1 . On the second substrate 3, three vertical through holes are drilled at intervals along the horizontal direction, and the first substrate 1 and the second substrate 3 are sealed together so that the two first substrates on the second substrate 3 Through hole 4 and a second through hole 6 communicate with microchannel 2; Wherein, figure 2 The outlet of the microchannel 2 is connected with the second through hole 6, so that the mixed solution flows out of the micromixer through the second through hole 6 through the microchannel 2.
[0019] Driven by positive pressure or negative pressure, different solutions enter the microchannel 2 through the two first through holes 4 in the direction perp...
Embodiment 2
[0022] Such as image 3 As shown, on the first substrate 1, a single linear microchannel 2 with a depth of 30 microns, a length of 3 cm, and a width of 200 microns is wet-etched on the first substrate 1; Drill two vertical first through holes 4 with a diameter of 500 microns, and the horizontal distance between the two first through holes 4 is 1 cm. The first substrate 1 and the second substrate 3 are sealed together at high temperature, so that the two first through holes 4 are aligned with the microchannel 2 , and the two first through holes 4 communicate with the microchannel 2 . A solution sampling interface 7 is bonded to the first through hole 4, and the solution sampling interface 7 is connected to a syringe pump through a capillary tube. This embodiment is not set as in embodiment 1 such as figure 2 The second through hole 6 shown, but a hole with a diameter of 0.4 mm and a depth of 2 mm is drilled at the end of the microchannel 2 and a quartz capillary 8 is inserte...
Embodiment 3
[0025] An example of an in-line reaction is provided according to Example 2. Such as image 3 As shown, the depth of a microchannel 2 is 50 microns, the length is 3 cm, and the width is 200 microns. A linear microchannel micro-mixer, a syringe pump injects hexavalent chromium solution into the mixer, and another syringe pump injects the hexavalent chromium solution into the mixer. Inject the color developer diphenylcarbazide solution into the mixer, fix the flow rate of the color developer at 15 μl / min, and inject the concentration of the hexavalent chromium solution into the mixer to be 0.125mg / L, 0.25mg / L, and 0.50mg / L respectively , 0.75mg / L and 1.00mg / L, the flow rate is 15μl / min, the solution flowing out of the mixer enters the flow-through detection cell, and the absorbance is detected in real time. The linear relationship curve between absorbance and concentration of hexavalent chromium solution is as follows: Figure 5 As shown, its linear correlation coefficient rea...
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Abstract
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