Selaginella pulvinata (Hook.et Grev.) Maxim. extract, extraction method and purpose

A technique of Selaginella cuspidatum, extraction method, applied in the new field of Selaginella cuspidatum extract

Inactive Publication Date: 2010-05-26
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition to the above-mentioned compounds, there are no relevant literature reports on such compounds at home and abroad.

Method used

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  • Selaginella pulvinata (Hook.et Grev.) Maxim. extract, extraction method and purpose
  • Selaginella pulvinata (Hook.et Grev.) Maxim. extract, extraction method and purpose
  • Selaginella pulvinata (Hook.et Grev.) Maxim. extract, extraction method and purpose

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Embodiment

[0020] Take 18.0 kg of the whole herb of Selaginella cushion-like, extract twice under reflux with 75% ethanol, recover the solvent, and obtain a turbid concentrated solution. Stand still for 72 hours, filter, and extract the filtrate with petroleum ether and ethyl acetate in sequence. After extraction, the residual filtrate is subjected to polyamide column chromatography, ethanol-water gradient elution (30%, 60%, 95%), and washed with 60% alcohol Partially carried out polyamide column chromatography again, ethanol-water gradient elution, 250ml / Fr., Fr198-206 was separated by Prep-HPLC again, 70% MeOH was mobile phase, obtained pad-like Selaginaldehyde (15mg) and pad respectively Selaginella diol (15mg).

[0021] Cushion-shaped Selaginaldehyde orange-red powder (H 2 O, lyophilized), soluble in MeOH, insoluble in H 2 O. Silica TLC with CHCl 3 :CH 3 OH (10:0.9) developed, Rf = 0.30. Visible dark spots under UV light; NH 3 fumed fuchsia, H 2 SO 4 -MeOH is pink, FeCl 3 T...

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Abstract

The invention relates to a selaginella pulvinata (Hook.et Grev.) Maxim. extract, an extraction method and purpose of the selaginella pulvinata (Hook.et Grev.) Maxim. extract. In the invention, Selaginella pulvinata (Hook.et Grev.) Maxim.is further researched, a plurality of column chromatogram separation technologies and a high performance liquid chromatography separation method are adopted to separate and extract two new compounds, i.e. Selaginella pulvinata (Hook.et Grev.) Maxim. aldehyde and Selaginella pulvinata (Hook.et Grev.) Maxim. diphenol, and the structures of the obtained compounds are strictly characterized. The prepared new compounds can be used for preparing medicaments for resisting Alzheimer diseases.

Description

technical field [0001] The invention relates to a new kind of extract of Selaginella cuspidatum, and also relates to its extraction method and application. Background technique [0002] There are about 700 species of plants in the genus Selaginella, which are widely distributed all over the world. There are more than 50 species produced in my country, which are distributed in various places. The 2005 edition of "Chinese Pharmacopoeia" included two varieties of Selaginella tamariscina (Beauv.) Spring and Selaginella cuspidatum S.pulvinata (Hook.et Grev.) Maxim. In addition to the pharmacopoeia varieties, there are about 20 other varieties of volumes. Cypress is used as medicine in folk. The chemical composition of Selaginella is mainly biflavonoids, followed by alkaloids, phenylpropanoids, steroids, polysaccharides and so on. Selaginella chinensis (S. moellendrfii hieron.) has the functions of clearing heat and detoxifying, anti-cancer and hemostasis. It is used to treat ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C47/57C07C45/78C07C39/21C07C37/68A61K31/11A61K31/05A61P25/28
Inventor 谭桂山李元建徐康平姜德建李福双周应军刘苏友
Owner CENT SOUTH UNIV
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