Method for preparing flavonoid compounds, used intermediate and preparation method thereof

A technology of flavonoids and compounds, applied in the direction of sugar derivatives, organic chemistry, drug combination, etc., can solve the problems of low extraction efficiency, difficult to meet research applications, complex and cumbersome operations, etc.
CN101712704AInactive Publication Date: 2010-05-26SHANGHAI INST OF PHARMA IND
2 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF PHARMA IND
Publication Date
2010-05-26
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a method for preparing flavonoid compounds shown in formula A, which comprises the following step: performing dehydroxylation protecting group reaction of the compounds shown in a formula B in a mixed solvent of a non-protonic solvent and an alcohol solvent under the action of an alkaline reagent to form the flavonoid compounds shown in the formula A, wherein R1 is -CO (CH2)n CH3 or benzoyl, n is 0 to 8, and Bz is benzoyl. The invention also relates to a new intermediate compound shown in the formula B and a preparation method thereof. Compared with the conventional method for extracting the flavonoid compounds shown in the formula A by separating from plants, the synthesis method of the invention makes the large-scale industrialized production of the compounds become possible; and the method of the invention has simple steps, has no strict requirements on a special reagent and reaction conditions, and has higher yield and purity.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a preparation method of flavonoids, an intermediate used and a preparation method thereof. Background technique

[0002] Common ischemic diseases include coronary heart disease, cerebral insufficiency, cerebral infarction and other heart and cerebrovascular ischemic diseases, which are one of the main diseases that endanger human health. Ischemic cerebrovascular diseases account for 50-70% of all cerebrovascular diseases, and are characterized by high morbidity, high mortality and high disability rate. health.

[0003] Apigenin 7-O-β-D-glucoside-4`-O-α-L-rhamnoside (Formula A) (English name: apigenin-7-O-β-D-glucopyranosyl-4`-O- α-L-rhamnopyranosid) is a flavonoid compound, which can be extracted and isolated from Ranunculus genus plants, such as Ranunculus sieboldii and R. sceleratus, and has certain anti-tumor, anti-HBV and The role of HSV-1. (Pan Yunxue, Study on the Chemical Constituents of Ranunculus chinensis, Chinese ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More