Intermediate of flavonoid compound and preparation method and application thereof

A technology for flavonoids and compounds, which is applied in the fields of sugar derivatives, organic chemistry, drug combinations, etc., can solve the problems of low extraction efficiency, difficulty in meeting research applications, complicated and tedious operations for separating and extracting compounds of formula A, etc.
CN101712702AInactive Publication Date: 2010-05-26SHANGHAI INST OF PHARMA IND CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF PHARMA IND CO LTD
Publication Date
2010-05-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an intermediate of a flavonoid compound shown in a formula C and a preparation method thereof. In the mixed solvents of a non-protonic solvent and an alcohol solvent, under the action of a catalyst for catalytic hydrogenation, the compound shown in the formula D undergoes catalytic hydrogenation to remove benzyl, wherein R1 is -CO(CH2)nCH3 or benzoyl; n ranges from 0 to 8; Bn is the benzyl; and Bz is the benzoyl. The invention also relates to application of the intermediate of the flavonoid compound shown in the formula C in preparation of the flavonoid compound shown in the formula A. Compared with the conventional method for separating and extracting the flavonoid compound shown in the formula A from the plant, the method for preparing the flavonoid compound shown in the formula A from the intermediate of the flavonoid compound shown in the formula C can realize large-scale industrialized production, and has the advantages of simple steps, no special reagent or harsh requirements on reaction conditions, and high yield and purity.
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Description

Technical field

[0001] The invention relates to a class of flavonoid compound intermediates and a preparation method and application thereof. Background technique

[0002] Common ischemic diseases include coronary heart disease, cerebral insufficiency, cerebral infarction, and other cardiac and cerebrovascular ischemic diseases, which are one of the main diseases that endanger human health. Ischemic cerebrovascular diseases account for 50 to 70% of all cerebrovascular diseases, and have the characteristics of high morbidity, high mortality and high disability. In recent years, the incidence and mortality of this type of disease have been ranked first, seriously harming human beings. Health.

[0003] Apigenin 7-O-β-D-glucopyranosyl-4`-O-α-L-rhamnoside (Formula A) (English name: apigenin-7-O-β-D-glucopyranosyl-4`-O- α-L-rhamnopyranosid) is a flavonoid compound, which can be extracted and isolated from Ranunculus plants, such as Ranunculus sieboldii and R. sceleratus. It has certain...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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