Preparation method of carboxymethyl chitosan quaternary ammonium salt in water phase by microwave irradiation

Abstract

The invention relates to a microwave radiation preparation method of carboxymethyl chitosan quaternary ammonium salt in water phase. The method uses chitosan as a raw material, chloroacetic acid as a carboxymethylation reagent, and 2,3-epoxypropyltrimethylammonium chloride as a quaternization reagent. Secondary microwave radiation, successive substitution reactions, separation and purification, freeze-drying to obtain carboxymethyl chitosan quaternary ammonium salt. The carboxymethyl chitosan quaternary ammonium salt product has a carboxymethyl substitution degree of 30-90%, and a quaternary ammonium group substitution degree of 15-90%. The preparation of shell carboxymethyl polysaccharide quaternary ammonium salt by the method of the present invention has the characteristics of simple process, short reaction time, high product yield, easy control of reaction conditions, no addition of organic solvents and good repeatability, etc., and has broad application prospects. .

Description

technical field [0001] The invention relates to the technical field of preparation of carboxymethyl chitosan quaternary ammonium salt, in particular to a microwave radiation preparation method of carboxymethyl chitosan quaternary ammonium salt in water phase. Background technique [0002] Chitosan is an alkaline polysaccharide that widely exists in nature. Its molecular structure contains active groups such as amino groups and hydroxyl groups. It can be modified by chemical reactions to make it have more ideal chemical, physical properties and physiological functions. , has broad application prospects in the fields of drug sustained release, functional food, biofunctional materials, cosmetics, sewage treatment and biotechnology. [0003] Carboxymethyl chitosan quaternary ammonium salt is a chitosan derivative that simultaneously introduces carboxymethyl and quaternary ammonium groups on chitosan molecules. Compared with chitosan, carboxymethyl chitosan and chitosan quaterna...

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Problems solved by technology

[0004] At present, there are relatively few studies on the preparation method of carboxymethyl chitosan quaternary ammonium salt. The only report about the preparation of carboxymethyl chitosan quaternary ammonium salt is to use traditional heating methods with organic solvents such as isopropanol as the dispersion medium. Prepare the finished product of carboxymethyl chitosan, and then use an organic solvent such as isopropanol as a dispersion medium to quaternize carboxymethyl chitosan to prepare a carboxymethyl chitosan quaternary ammonium salt. A total of more than ten Hours, long reaction time, cumbersome steps, difficult to control experimental conditions, and a burden to the environment

The microwave radiation synthesis method has attracted much attention due to its fast, simple and efficient characteristics. However, so far, there has been no report on the preparation of carboxymethyl chitosan quaternary ammonium salt in aqueous phase by microwave radiation method.