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Method for extracting ascorbyl-2-phosphate through bipolar membrane electrodialysis

A bipolar membrane electrodialysis, ascorbic acid technology, applied in electrodialysis, chemical instruments and methods, compounds of elements of Group 5/15 of the periodic table, etc., can solve the problem of insufficient dechlorination, large waste water output and low product yield and other problems, to achieve the effect of reducing raw material cost, reducing output and improving separation yield

Inactive Publication Date: 2010-06-23
BEIJING UNIV OF CHEM TECH
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0017] The purpose of this invention is to provide a method for extracting AMP using bipolar membrane electrodialysis technology to solve the problems of insufficient dechlorination in traditional separation processes, large waste water output, lengthy process, low product yield and waste of resources. The production of phosphate ester provides a clean and green separation and purification process

Method used

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  • Method for extracting ascorbyl-2-phosphate through bipolar membrane electrodialysis
  • Method for extracting ascorbyl-2-phosphate through bipolar membrane electrodialysis
  • Method for extracting ascorbyl-2-phosphate through bipolar membrane electrodialysis

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Pass the synthesized mixed solution into acid / salt / alkali three-chamber electrodialyzer (attached figure 1 ) of the salt chamber, and circulate at a speed of 50L / h. Then pass 500ml of deionized water into the two chambers of acid and alkali respectively, and circulate at a speed of 50L / h respectively. Use 5 mol / L KOH solution to stably control the pH of the salt chamber to 9 through a potentiometric titrator. The control voltage is 10V, and the maximum current density is 10mA / cm 2 , the operating temperature is 30 ° C, after 2 hours of reaction, ion chromatography detects Cl - The residual amount is 6.2g and the removal rate is 83.5%.

[0046] Add 10% H dropwise to the salt chamber 3 PO 4 The pH of the solution was adjusted to 1 and allowed to stand for 30 min. After replacing the HCl solution in the acid chamber with 300ml of deionized water, a second stage of electrodialysis was performed. The control voltage is 10V, and the maximum current density is 10mA / cm ...

Embodiment 2

[0050] The method is the same as in Example 1, except that different experimental conditions are selected for separation. The results are shown in Table 1-3.

[0051] Table 1 Cl-removal rate under different pretreatment and primary electrodialysis conditions

[0052]

[0053] Table 2 AMP yield under different deprotection, two-stage electrodialysis and salt-forming conditions

[0054]

[0055] Note: *N AMP : Multiple of AMP moles

[0056] Table 3 Product purity and separation total yield obtained under different concentration, decolorization, crystallization and drying conditions

[0057]

[0058]

Embodiment 3

[0060] The same as the method of Example 1, the difference is that the electrodialyzer is assembled between a pair of electrodes with three groups of attached figure 1 Repeat unit membrane groups shown, forming multiple compartments, as attached figure 2 As shown, the compartment combination is anode chamber / acid chamber / salt chamber / alkali chamber / acid chamber / salt chamber / alkali chamber / acid chamber / salt chamber / alkali chamber / cathode chamber. The salt chamber was all poured into the reaction solution (5,6-O-isopropyl-AMP: 25.2g; Cl - : 47.5g; PO 4 3- : 20.6g) a total of 590ml. The primary electrodialysis control voltage is 18V, and the maximum current density is 30mA / cm 2 , reaction 1.5h, Cl - The residual amount is 3.1 g, and the removal rate is 93.4%. The condition of the second-stage electrodialysis is consistent with that of the first-stage electrodialysis. After 2 hours of reaction, the content of AMP in the acid chamber solution is 24.7 g, and the yield is 98%....

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Abstract

The invention discloses a method for separating high-purity AMP through the bipolar membrane electrodialysis technology. Cl- in AMP reaction liquid is effectively removed by using the obvious difference between the migration speed of 5, 6-O-isopropyl ascorbyl phosphate in electrodialysis membrane modulus and the migration speed of Cl-in the electrodialysis membrane modulus. Alkali metal positive ions and negative ions in the AMP reaction liquid are separated by using the resolving function of the bipolar membrane electrodialysis to positive ions and negative ions, so acidic deprotected AMP is obtained and alkali metal is recovered and is cyclically used for AMP synthetic reaction. The acidic deprotected AMP and alkali-earth metal oxides form AMP alkaline-earth metal salts through salt formation. Moreover, phosphate ions which are not removed from solution can be removed through sedimentation. Finally, high-purity AMP alkaline-earth metal salts are obtained through concentration, decolorization, crystallization and drying.

Description

technical field [0001] The invention relates to a new method for extracting high-purity ascorbic acid-2-phosphate by using bipolar membrane electrodialysis technology, which belongs to the field of medicine extraction and separation. technical background [0002] Ascorbic acid, also known as vitamin C (Vitamin C, VC), is an essential vitamin for the human body, and has extensive and important uses in food, medicine, feed, chemical and other fields. However, its application is limited due to its high redox activity. Ascorbyl monophosphate (AMP) is one of the most chemically stable VC derivatives, which is not easily oxidized, resistant to alkali and metal ions. After entering the human body, AMP can quickly enzymatically decompose free VC. It is an ideal and stable water-soluble VC source. Therefore, it has been widely used as a substitute for VC in food, medicine, cosmetics, detergent, feed and other industries. [0003] At present, AMP is mainly synthesized by chemical me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/655B01D61/42
Inventor 谭天伟宋爽
Owner BEIJING UNIV OF CHEM TECH
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