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Preparation process of effective part of flower of abelmoschus manihot-total flavone extractive and new use thereof

A technology of effective parts, hollyhock flowers, applied in the field of biomedicine

Inactive Publication Date: 2010-06-30
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results of this study suggest that the flavonoids of hollyhock flower may also have certain effects on peptic ulcers such as gastric ulcer and duodenal ulcer, but there is no treatment of gastric ulcer and duodenal ulcer with total flavonoids of hollyhock flower. literature reports

Method used

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  • Preparation process of effective part of flower of abelmoschus manihot-total flavone extractive and new use thereof
  • Preparation process of effective part of flower of abelmoschus manihot-total flavone extractive and new use thereof
  • Preparation process of effective part of flower of abelmoschus manihot-total flavone extractive and new use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 Preparation of effective parts of hollyhock flowers—total flavonoids extract

[0015] Add an appropriate amount of 80% ethanol to the hollyhock flower, extract once, extract for 2 hours, combine the extracts, filter, concentrate the filtrate into a concentrated solution with a relative density of 1.13-1.16 at 60°C, add an appropriate amount of water to sink for 24 hours, and filter with suction. Concentrate to the corresponding volume, pass through a macroporous adsorption resin column, use alcohol-water gradient elution, water elution 3 column volumes, 10% and 30% ethanol each elution 3 column volumes, 70% ethanol elution 1 column volume . The eluate is concentrated, dried and pulverized to obtain the total flavonoid extract of the marshmallow flower, and the total flavonoid content is 65%.

Embodiment 2

[0016] Example 2 Preparation of Capsules of Effective Fractions of Total Flavonoids of Melhock Flowers

[0017] Take 250g of the extract of effective fractions of total flavonoids from hollyhock flowers, 50g of magnesium stearate, pass through an 80-mesh sieve, mix well, dry granulate, fill 1000 capsules, and each capsule contains 250mg of effective fractions from total flavonoids from hollyhock flowers. Usage: 2 capsules each time, three times a day.

Embodiment 3

[0018] Example 3 The preparation of the active fraction tablet of total flavonoids of hollyhock flower

[0019] Take 250g of the effective part extract of total flavonoids of hollyhock flower and 45g of microcrystalline cellulose, mix well, wet granulate with ethanol, and pass through a 20-mesh sieve. Add 5 g of magnesium stearate, mix evenly, and press to form 1000 tablets with a tablet weight of 0.3 g / tablet, each containing 250 mg of active parts of total flavonoids from hollyhock flowers. Usage: 2 tablets each time, three times a day.

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Abstract

The invention provides a preparation process of an effective part of flower of abelmoschus manihot-a total flavone extractive and a new use thereof, in particular relating to the use in preparing medicines for treating acute and chronic gastritis, peptic ulcer, burns and scalds, traumatic infections and tumors and carbuncles.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular refers to a new application of the effective part of hollyhock flower-total flavonoids extract, specifically in the preparation of medicines for treating acute and chronic gastritis, digestive ulcers, burns, trauma infections and carbuncles. Uses in medicine. Background technique [0002] Hollyhock flower is the dry corolla (with stamens and style) of Abelmoschus manihot (L.) Medic., a plant of Malvaceae. 2002 edition. It has the effects of clearing dampness and heat, reducing inflammation and detoxification. It is a traditional medicinal plant in my country. The history of its use as medicine can be traced back to 1500 years ago in "The Back of the Elbow" written by Ge Hong in the Jin Dynasty. Gonorrhea, carbuncle, swollen toxin, and burns caused by soup and fire.” There are many applications among the people to treat furuncles, mumps, urinary tract infections, lung-heat coughs, and...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/04A61P17/02A61P31/02A61K133/00
Inventor 张玲凌沛学尚立霞曲延伟吴永霞
Owner 凌沛学
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