High-strength plasticized coral artificial bone and preparation method thereof

Abstract

The invention discloses a high-strength plasticized coral artificial bone and a preparation method thereof. The artificial bone comprises the raw materials of natural coral knolls, bone cement and auxiliary materials, wherein the natural coral knolls are porites the micropore diameter of which is 200-500mu m; and the bone cement is acrylic acid bone cement. The preparation method of the artificial bone comprises the steps of raw material preparation, padding, moulding and drying and finished product inspection and acceptance, wherein the process step of padding is that the raw materials are placed in a centrifuge to perform high speed centrifugation; the bone cement is used for performing micropore padding on the natural coral knolls under the action of high speed centrifugal force; the high speed centrifugation is carried out for 2-8min at the room temperature of 25-28 DEG C; and the centrifugal force of the high speed centrifugation is adjusted and controlled to be 1-10g according to the size of the natural coral knolls. The invention can be widely used in each field of medicine, has simple and feasible process and environment-friendly production process. The preparation method of the invention is applicable to enterprises manufacturing the coral artificial bones.

Description

technical field [0001] The invention relates to a medical artificial bone and its preparation technology, in particular to a high-strength artificial bone that can significantly improve the strength of the medical artificial bone, significantly reduce the production cycle and cost in the production process, and meet the requirements of environmental protection for production emissions. Plasticized coral artificial bone and its preparation method. Background technique [0002] Bone graft filling of bone defects, and bone graft materials required for fusion of spine and joints have always been important research directions for bone reconstruction and repair. The focus of research is to find biomaterials with good physical and chemical properties and biological characteristics as bone graft materials. A variety of materials have been used for the repair of bone defects, such as allogeneic bone, allogeneic allogeneic bone, allogeneic calcined bone, etc., and have achieved certa...

AI Technical Summary

Problems solved by technology

However, the immunogenicity of traditional allogeneic bone and xenograft bone has not been effectively overcome. In clinical application, it is found that the difference is too large compared with autologous bone transplantation, and the clinical application effect is not ideal.

[0003] Artificial synthetic materials such as hydroxyapatite, calcium phosphate substances, and tricalcium phosphate TCP, due to the limitations of current technology and technology, their mechanical strength cannot meet the requirements. There are many pores or large variation in porosity, and the pore traffic cannot meet the structural requirements of bone tissue in-growth

In 1971, it was discovered that coral has a pore structure similar to that of human bone, and has good biocompatibility, and began to use the original coral hydroxyapatite as a bone graft material. Difficult in precision machining, affecting bone formation, especially when applied to parts that require certain mechanical support, there are obvious restrictions