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Cefmetazole sodium suspension injection powder and novel application thereof

A cefmetazole sodium suspension technology, applied in the field of medicine, can solve the problems of low bioavailability and poor stability, and achieve the effects of reducing drug toxicity, not easy to decompose, and improving stability

Inactive Publication Date: 2011-09-14
HAINAN LINGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The object of the present invention is to provide a kind of cefmetazole sodium suspension powder injection, wrapping by pharmaceutically acceptable biodegradable polymer, adopt double emulsification technology to make cefmetazole sodium suspension powder injection of the present invention, very Well solved the problems of poor stability and low bioavailability of the currently marketed cefmetazole sodium preparation solution, and achieved ideal technical effects

Method used

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  • Cefmetazole sodium suspension injection powder and novel application thereof
  • Cefmetazole sodium suspension injection powder and novel application thereof
  • Cefmetazole sodium suspension injection powder and novel application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 Preparation of Cefmetazole Sodium Suspension Powder Injection

[0043] Prescription: (100 bottles)

[0044] Cefmetazole Sodium 25g

[0045] Chitosan 30g

[0046] Fatty Acid Sorbitan 20 25g

[0047] Sodium cholate 20g

[0048] Sodium chloride 23g

[0049] Ethanol 400ml

[0050] Preparation Process:

[0051] (1) 25 g of cefmetazole sodium was dissolved in 400 ml of water, 30 g of chitosan and 20 g of sodium cholate were added to 400 ml of ethanol for dissolving, then mixed with the aqueous solution and stirred for 30 min to obtain an emulsion;

[0052] (2) 25g fatty acid sorbitan 20 is dissolved in 200ml water for injection;

[0053] (3) The emulsion is evaporated to remove the organic solvent, the fatty acid sorbitan 20 solution in (2) is added in the emulsion, then 23g of sodium chloride is added, after stirring at room temperature, freeze-dry to obtain cefmetazole sodium suspension Powder preparations.

Embodiment 2

[0065] Example 2 Preparation of Cefmetazole Sodium Freeze-dried Suspension Powder Injection

[0066] Prescription: (100 bottles)

[0067] Cefmetazole Sodium 12.5g

[0068] Chitosan 26g

[0069] Polysorbate 80 21.6g

[0070] Glycerin 18g

[0071] Mannitol 16g

[0072] Isopropanol 400ml

[0073] Preparation Process:

[0074] (1) 12.5 g of cefmetazole sodium was dissolved in 350 ml of water, 26 g of chitosan and 18 g of glycerin were added to 400 ml of isopropanol for dissolving, then mixed with the aqueous solution and stirred for 30 min to obtain an emulsion;

[0075] (2) 21.6g polysorbate 80 was dissolved in 200ml water for injection;

[0076] (3) Evaporate the emulsion to remove the organic solvent, add the solution in (2) to the emulsion, add 16g of mannitol, stir evenly at room temperature, freeze-dry to obtain cefmetazole sodium suspension powder preparation.

Embodiment 3

[0077] Example 3 Preparation of Cefmetazole Sodium Freeze-dried Suspension Powder Injection

[0078] Prescription: (100 bottles)

[0079] Cefmetazole Sodium 12.5g

[0080] Gelatin 16g

[0081] Polysorbate 80 14g

[0082] Fatty Acid Sorbitan 20 8g

[0083] Glycerin 18g

[0084] Lactose 10g

[0085] Sodium chloride 26g

[0086] Ethanol 400ml

[0087] Preparation Process:

[0088] (1) Dissolve 12.5 g of cefmetazole sodium in 400 ml of water, add 16 g of gelatin and 18 g of glycerin into 400 ml of ethanol for dissolving, then mix and stir with the aqueous solution for 30 min to obtain an emulsion;

[0089] (2) Dissolve 14g polysorbate 80 and 8g fatty acid sorbitan 20 in 200ml water for injection

[0090] (3) The emulsion is evaporated to remove the organic solvent, the solution in (2) is added to the emulsion, then 26g of sodium chloride is added, after stirring at room temperature, freeze-dry to obtain cefmetazole sodium suspension powder preparation .

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Abstract

The invention provides cefmetazole sodium suspension injection powder and a preparation method thereof. The cefmetazole sodium suspension injection powder comprises the following components by weight part: 10 parts of cefmetazole sodium, 5 to 30 parts of biodegradable polymer receivable on pharmacy, 1 to 20 parts of emulsifier, 6 to 12 parts of emulsion assistant and 2 to 30 parts of skeleton agent. The cefmetazole sodium suspension injection powder has the application for treating body extensive Psoriasis Pustulosa.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a cefmetazole sodium suspension powder injection and a preparation method thereof, and further relates to the use of the preparation in treating generalized pustular psoriasis. Background technique [0002] Pustular psoriasis is one of the more serious types of psoriasis and can be divided into two types, one is localized and the other is generalized. Most of the cases selected in this study were generalized. The clinical manifestations were high fever, joint swelling and pain, and general malaise. Blood routine tests showed an increase in the number of white blood cells. Generalized pustular psoriasis is the most severe clinical type. It is rare and has an unknown etiology. External use of stimulant drugs, infection, and sudden withdrawal of drugs during the application of glucocorticoids or immunosuppressants are all precipitating factors. . Sudden onset, flaccid high feve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K31/546A61K47/32A61K47/34A61K47/36A61K47/42A61P17/06
Inventor 王明
Owner HAINAN LINGKANG PHARMA CO LTD
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