Palladium-doped nano titanium dioxide anti-bacterial agent and preparation method and application thereof

A technology of nano-titanium dioxide and antibacterial agent, which is applied in the field of antibacterial materials, and can solve the problems of rare nano-titanium dioxide antibacterial agent

Inactive Publication Date: 2010-07-28
QUFU NORMAL UNIV
3 Cites 12 Cited by

AI-Extracted Technical Summary

Problems solved by technology

[0004] The research on palladium-doped nano-titanium dioxide antibacterial agent is still rare. Up to now, the preparation of palladium-doped nano-t...
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Abstract

The invention relates to a palladium-doped nano titanium dioxide anti-bacterial agent and a preparation method and an application thereof, belonging to the technical field of antibacterial material. The preparation method comprises the following steps: dropwise adding PdCI2 solution to the mixed solution of tetrabutyl titanate and isopropanol; after ageing, washing and drying the mixture to gel; grinding the mixture before carrying out calcination, thus obtaining the palladium-doped nano titanium dioxide anti-bacterial agent. The invention features simple production technology, high product purity, small grain diameter, good thermal stability, strong antibiotic property and can catalyze part of palladium catalytic reaction.

Application Domain

BiocideDisinfectants +2

Technology Topic

Anti bacterialTitanium dioxide +6

Image

  • Palladium-doped nano titanium dioxide anti-bacterial agent and preparation method and application thereof
  • Palladium-doped nano titanium dioxide anti-bacterial agent and preparation method and application thereof
  • Palladium-doped nano titanium dioxide anti-bacterial agent and preparation method and application thereof

Examples

  • Experimental program(1)

Example Embodiment

[0009] An antibacterial agent palladium-doped nano titanium dioxide, characterized in that the palladium doping amount is 1 to 5 mol%, and the average particle size of the palladium-doped nano titanium dioxide particles is 6-12 nm; it is made of PdCl 2 The solution was added dropwise to the isopropanol solution of tetrabutyl titanate at 30°C.
[0010] Preferably, the doping amount of palladium is 3 mol%.
[0011] A preparation method of nano titanium dioxide doped with antibacterial agent palladium, which is characterized in that the steps are as follows:
[0012] (1) PdCl 2 Dissolve in double distilled water to obtain solution A;
[0013] (2) Add tetrabutyl titanate dropwise to isopropanol, stir at room temperature for 30 minutes, adjust the pH value to 3-4 with acid to obtain solution B;
[0014] (3) At 30° C., use a constant pressure funnel to drop the solution A prepared in step (1) into the solution B prepared in step (2), stir at room temperature, and then age to obtain a sol;
[0015] (4) Wash the sol prepared in step (3) with distilled water until AgNO 3 The solution does not detect chloride ions, and it dries to get a gel;
[0016] (5) After grinding the gel prepared in step (4), it is calcined to obtain palladium-doped nano titanium dioxide powder, which is the antibacterial agent palladium-doped nano titanium dioxide.
[0017] Preferably, the acid in the step (1) is concentrated nitric acid with a concentration of 6M.
[0018] Preferably, the stirring time in the step (3) is 2h, and the aging time is 2h.
[0019] Preferably, the drying conditions in the step (4) are 80° C. and drying for 24 hours.
[0020] Preferably, the calcination condition in the step (5) is calcination at 450° C. for 2 h.
[0021] Application of the antibacterial agent palladium-doped nano titanium dioxide in antibacterial and antibacterial aspects.
[0022] The application of the antibacterial agent palladium-doped nano titanium dioxide in the aseptic palladium catalytic reaction.
[0023] The antibacterial effect test of the prepared antibacterial agent palladium-doped nano titanium dioxide by microcalorimetry:
[0024] The basic principle of microcalorimetry:
[0025] Establish an exponential growth model based on the restrictive growth conditions of microbial culture and derive the Logistic equation:
[0026] P t =P m /(1+αe -μt )
[0027] Where μ is the growth rate constant, α is the integral constant, P m And P t They are the maximum output power of bacteria and the output power of bacteria at time t. P obtained from the experimental test curve of thermal power-time m And P t etc Numerical value, the value of the growth rate constant μ is obtained by linear regression analysis, and the relationship between the growth rate constant μ and the concentration of antibacterial agent C is established through computer simulation. When the growth rate constant μ=0, the minimum inhibitory concentration (MIC) value of the antibacterial agent is obtained. The smaller the value, the better the antibacterial effect.
[0028] The experimental procedure for determining the effect of palladium-doped nano-titanium dioxide on the growth and metabolism of E. coli by microcalorimetry is as follows:
[0029] (1) Before the experiment, sterilize the instruments used under UV light for 30 minutes.
[0030] (2) Measure an appropriate amount of Escherichia coli bacteria from the liquid culture medium and add it to a certain amount of salt water to form a solution with the required concentration for the experiment.
[0031] (3) Weigh an appropriate amount of palladium-doped nano-titanium dioxide powder, add 10 mL of DMF (dimethylformamide), and ultrasonically disperse for 10 min, for use.
[0032] (4) Pipette 8 mL of the bacterial solution in (2) above and place them in 8 ampoules. No palladium-doped nano-titanium dioxide solution was added to the first ampoule, and a certain concentration of palladium-doped nano-titanium dioxide solution was sequentially added to the other 7 ampoules, the volumes were 50, 100, 150, 200, 250, 300, 350uL. After sealing, put it into the thermal activity detector and start recording data. When the thermal power-time curve of bacterial metabolism returns to the baseline, the experiment is considered to be over.
[0033] The palladium-doped nano titanium dioxide prepared by the method of the present invention has the following advantages:
[0034] 1. The prepared palladium-doped nano titanium dioxide powder has high purity, which can reach 98.5 mol%.
[0035] 2. The solution prepared by adding tetrabutyl titanate to isopropanol solvent and PdCl 2 The solution is mixed to prepare palladium-doped nano titanium dioxide powder, the particle size is small and uniform, and the average particle size can reach 6-12nm.
[0036] 3. The prepared palladium-doped nano titanium dioxide antibacterial agent has stable performance and strong antibacterial properties.
[0037] 4. The process is simple, the equipment requirements are low, the raw materials are easily available, and mass production is possible.
[0038] 5. When the doping amount of palladium is 1 to 3 mol%, the prepared nano titanium dioxide is anatase type; when the doping amount of palladium is 4 to 5 mol%, the prepared nano titanium dioxide is a mixture of anatase type and rutile type .
[0039] 6. In addition to being used as an antibacterial agent, palladium-doped nano titanium dioxide also has catalytic properties and can be used as a catalyst for partial palladium catalytic reactions.

PUM

PropertyMeasurementUnit
The average particle size6.0 ~ 12.0nm

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