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Hyaluronic acid/polyacrylonitrile compound film, method for preparing same and application thereof

A technology of polyacrylonitrile-based membrane and hyaluronic acid, which is applied in the direction of semipermeable membrane separation, chemical instruments and methods, membrane technology, etc., can solve the problems of few reports and no reports, and achieve simple preparation method and improved phase Satisfied effect of capacitive and thermal stability

Active Publication Date: 2010-07-28
南通诚恩机械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the adhesive protein secreted by it can quickly form a solidified layer in the seawater environment so that it can be firmly attached to various wet surfaces, and compared with traditional adhesives, bioadhesives have no need for The advantages of high temperature adhesion and non-toxicity have inspired people to use bioadhesives to enhance interfacial interactions, but there are few reports on the application of bioadhesives to the preparation of composite films, especially the use of hyaluronic acid bio Adhesives used in the preparation of composite membranes have not been reported

Method used

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  • Hyaluronic acid/polyacrylonitrile compound film, method for preparing same and application thereof
  • Hyaluronic acid/polyacrylonitrile compound film, method for preparing same and application thereof
  • Hyaluronic acid/polyacrylonitrile compound film, method for preparing same and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] (1) Modification of polyacrylonitrile-based membrane: Soak a polyacrylonitrile-based membrane (Shanghai Lanjing Membrane Technology Co., Ltd., PAN10w, pore size range 20-50nm) with a size of 10cm×10cm in deionized water for 1 day to remove the membrane Glycerol on the surface, then soaked in 2M sodium hydroxide solution, soaked at 50 ° C for 1h, during this process, the cyano group on the polyacrylonitrile was hydrolyzed into carboxyl group, the color of the basement film turned orange, and then 0.1M After repeated washing with hydrochloric acid solution and deionized water, the color of the basement membrane turned yellow, and was air-dried. (2) Preparation of casting solution: 0.2g of hyaluronic acid with a viscosity-average molecular weight of 120w Da was dissolved in 50g of deionized water, stirred rapidly to make it completely dissolved, and prepared into 0.4wt.% hyaluronic acid solution, and then Add 0.6g of 2.5wt.% glutaraldehyde cross-linking agent, and slowly a...

Embodiment 2

[0022] (1) Modification of polyacrylonitrile-based membrane: the steps are the same as shown in Example 1. (2) Preparation of casting solution: 0.4g of hyaluronic acid with a viscosity-average molecular weight of 120w Da was dissolved in 50g of deionized water, stirred rapidly to make it completely dissolved, and prepared into 0.8wt.% hyaluronic acid solution, and then Add 1.2g of 2.5wt.% glutaraldehyde crosslinking agent, and slowly add 0.01M hydrochloric acid dropwise to adjust the pH, control the pH test paper to make it between 3-5, stir for 1h, and let the resulting gel stand overnight. (3) Preparation of composite film: the steps are the same as those shown in Example 1 (film 2).

Embodiment 3

[0024] (1) Modification of polyacrylonitrile-based membrane: the steps are the same as shown in Example 1. (2) Preparation of casting solution: 0.6g of hyaluronic acid with a viscosity-average molecular weight of 120wDa was dissolved in 50g of deionized water, stirred rapidly to make it completely dissolved, prepared into 1.2wt.% hyaluronic acid solution, and then added 1.8g 2.5wt.% glutaraldehyde crosslinking agent, slowly add 0.01M hydrochloric acid dropwise to adjust the pH, control the pH test paper to make it between 3-5, stir for 1h, and let the resulting gel stand overnight . (3) Preparation of composite film: the steps are the same as those shown in Example 1 (film 3).

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Abstract

The invention relates to a hyaluronic acid / polyacrylonitrile compound film, a method for preparing the same and application thereof. The compound film is prepared by using hyaluronic acid, glutaraldehyde and a polyacrylonitrile basal film as raw materials, wherein the mass ratio of the glutaraldehyd to the hyaluronic acid is 1-10:1, and the thickness ratio of the polyacrylonitrile basal film to the hyaluronic acid layer is 135-400:1. Particularly, the preparation method comprises the following steps of: coating acid casting solution of the glutaraldehyde-containing hyaluronic acid on the polyacrylonitrile basal film which is treated by water, alkali and acid in sequence, drying, and heating the polyacrylonitrile basal film for 0.5 to 3 hours. The preparation method has the advantages of simple method, mild conditions and low cost; and the hyaluronic acid separation layer is high in hydrophilicity, and simultaneously due to the bonding characteristics, the hyaluronic acid separation layer is closely combined with a support layer, so that the prepared hyaluronic acid / polyacrylonitrile compound film is high in stability and separation property, and can be widely applied to the film realizing the separation based on a solubility diffusion mechanism such as pervaporation.

Description

technical field [0001] The invention relates to a hyaluronic acid / polyacrylonitrile composite membrane, a preparation method and application thereof, which is a highly stable hyaluronic acid / polyacrylonitrile composite membrane and belongs to the membrane separation technology for separating organic matter-water. Background technique [0002] Compared with homogeneous membranes, composite membranes composed of active separation layer and support layer are more suitable for industrial applications due to their advantages of good mechanical properties and high permeation flux. Among them, the GFT membrane with maleic acid cross-linked polyvinyl alcohol as the separation layer and polyacrylonitrile as the support layer is the first industrialized membrane in the world. However, swelling is a common problem in the pervaporation process. If the separation layer and the support layer swell inconsistently, a large stress will be generated at the interface. If the stress is greater ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/12B01D71/42B01D71/08
Inventor 姜忠义张敏华马静聂明成刘冠晓
Owner 南通诚恩机械有限公司
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