Method for preparing granular herbal pieces prepared for decoction through steam explosion of monkshood

Abstract

The invention relates to the Chinese medicinal herbal pieces prepared for decoction processing field, in particular to a method for preparing granular herbal pieces prepared for decoction through steam explosion of monkshood. The method comprises the following steps: soaking fresh monkshood or unprocessed monkshood pieces to soften, performing low-pressure steam explosion of vapor phase to cook for a certain time for achieving the aim of detoxification, instantaneously reducing the pressure to ordinary pressure to explode monkshood, then drying the exploded monkshood in hot-air at a low temperature, and grinding to a certain mesh number to obtain the monkshood granular herbal pieces prepared for decoction. The method adopting the steam explosion of monkshood of the invention eliminates the traditional drug-processing and rinsing process and solves the problem that the traditional drug-processing method can not completely realize detoxification and precooking is needed to perform before optimizing the formula. Therefore, the traditional process is simplified, the effective components can not largely lost, thus the dissolution rate of the effective components is increased, the drug-processing process becomes accurate and fast, and the mass production is controllable.

Description

technical field [0001] The invention relates to a processing technology of traditional Chinese medicine, in particular to a simple, easy-to-control method for large-scale preparation of toxic raw aconite granule decoction pieces. Background technique [0002] Aconitum (Radix aconite lateralis prepareata, RALP) is a processed product of the root of Aconitum carmichaeli Debx, a ranunculaceae plant. It is a toxic drug commonly used in TCM clinics. Binding to the sodium ion channel leads to strong central nervous system toxicity. In order to reduce their toxicity, they must be processed before use to reduce the content of highly toxic aconitine diester alkaloids. [0003] From the Han Dynasty to the present, there have been various processing methods and operating techniques, but generally they have experienced "cannon broiling", "water rinsing", "water rinsing and cooking" and so on. The artillery method is to mix the aconite with clean river sand and stir-fry until it expand...

AI Technical Summary

Problems solved by technology

These concocting methods are more loaded down with trivial details, the required time is longer, the cost is relatively high

[0004] In order to improve the processing technology of aconite, experts have proposed some new processing methods, such as high-pressure cooking [Zhang Liping, Acute Toxicity Test Research of Aconite under Pressure, World Health Abstracts, 2008, 5(6): 401-402], that is, in Under pressure cooking at 0.245MPa, although the medicinal material processed by this method has the advantages of good drug effect and low toxicity, the required processing time is as long as 1.5h; Liu Shuying et al [CN1369278A] proposed the method of processing aconite with alkaline auxiliary materials method, although this method can shorten the processing time, it basically has the same idea as the traditional water bleaching method with auxiliary materials. The water bleaching process brings other chemical components into the medicinal materials, and the processing process also brings environmental pollution. Problem; people such as Liu Shuying [CN1903261A] proposed the method of soaking in the shade and drying in the shade. This method actually replaces the steamer in the traditional craft with an oven, and a considerable part of the active ingredients will still be lost in the process of water bleaching [Ran Fanxiong, famous and precious Chinese medicine Green Cultivation Technology of Pinellia, Pinellia, Pinellia, Aconite, Beijing: Science and Technology Press, 2002, 9]; Mr. Wu Rongzu [CN98114511.6] adopts the technological method of boiling alcohol, precipitating, concentrating, drying and granulating, avoiding the traditional process Methods The disadvantages of the large loss of effective biological activity caused by repeated soaking and cooking can improve the efficacy of the medicine and save resources. Provide a safe, effective, stable and convenient new product Fuzi granules for clinical use, which will finally be launched on the market and serve the clinic.

This method also cooks repeatedly, is difficult to control, and the inherent component (supernatant) of aconite is lost in alcohol precipitation process, and yield is low, and preparation cost is high, and the market is unsuitable for accepting

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