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Amoxicillin sodium flucloxacillin sodium medicine compound liposome injection

A technology of amoxicillin sodium, flucloxacillin sodium, and flucloxacillin sodium, which is applied in the direction of liposome delivery, active ingredients of heterocyclic compounds, antibacterial drugs, etc., and can solve the problem of poor product stability, affecting clinical efficacy, and active ingredient amoxicillin. Moxicillin sodium and flucloxacillin sodium protection and other issues, to achieve high stability, reduce drug side effects, improve the effect of drug therapeutic index

Inactive Publication Date: 2010-08-25
HAINAN MEILAN SMITH KLINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method simply mixes and subpackages the two, and does not protect the active ingredients amoxicillin sodium and flucloxacillin sodium accordingly, resulting in poor product stability and seriously affecting the clinical efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation of Liposome Injection of Amoxicillin Sodium and Flucloxacillin Sodium Pharmaceutical Composition

[0027] Prescription (specification 0.5g)

[0028] Amoxicillin Sodium 25g

[0029] Flucloxacillin sodium 25g

[0030] Soy Lecithin 100g

[0031] Cholesterol 20g

[0032] Glucose 62.5g

[0033] Mannitol 62.5g

[0034] Sodium benzoate 2.5g

[0035] Preparation Process

[0036] (1) Dissolve 100 g of soybean lecithin and 20 g of cholesterol in 800 ml of a mixture solvent of isopropanol and ethanol with a volume ratio of 3:1, place them on a rotary thin film evaporator and remove the organic solvents under reduced pressure to obtain a phospholipid membrane. 500ml of pH 5.6 citrate-sodium citrate buffer solution was stirred and dissolved to obtain a blank liposome solution;

[0037] (2) Dissolve 25g of amoxicillin sodium and 25g of flucloxacillin sodium in 300ml of water for injection, mix them with the prepared blank liposome solution, sonicate for 40 minutes at 70℃, and ...

Embodiment 2

[0039] Example 2 Preparation of Liposome Injection of Amoxicillin Sodium and Flucloxacillin Sodium Pharmaceutical Composition

[0040] Prescription (Specification 1.0g)

[0041] Amoxicillin Sodium 50g

[0042] Flucloxacillin Sodium 50g

[0043] Soy Lecithin 300g

[0044] Cholesterol 75g

[0045] Glucose 250g

[0046] Mannitol 250g

[0047] Sodium benzoate 35g

[0048] Preparation Process

[0049] (1) Dissolve 300g of soybean lecithin and 75g of cholesterol in 1500ml of a mixture of isopropanol and ethanol with a volume ratio of 3:1, place them on a rotary thin film evaporator and remove the organic solvents under reduced pressure to obtain a phospholipid membrane. 800ml of pH 5.6 citric acid-sodium citrate buffer solution was stirred and dissolved to obtain a blank liposome solution;

[0050] (2) Dissolve 50g of amoxicillin sodium and 50g of flucloxacillin sodium in 500ml of water for injection, mix them uniformly with the prepared blank liposome solution, and sonicate for 60 minutes at 50℃,...

Embodiment 3

[0052] Example 3 Preparation of Amoxicillin Sodium and Flucloxacillin Sodium Pharmaceutical Composition Liposome Injection

[0053] Prescription (specification 2.0g)

[0054] Amoxicillin Sodium 100g

[0055] Flucloxacillin Sodium 100g

[0056] Soy Lecithin 500g

[0057] Cholesterol 120g

[0058] Glucose 350g

[0059] Mannitol 350g

[0060] Sodium benzoate 30g

[0061] The preparation process was the same as in Example 2, and the liposome injection of the pharmaceutical composition of amoxicillin sodium and flucloxacillin sodium was prepared.

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PUM

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Abstract

The invention provides an amoxicillin sodium flucloxacillin sodium medicine compound liposome injection which comprises amoxicillin sodium, flucloxacillin sodium, liposome carrier, lyoprotectant and optionally existing preservative, wherein the liposome carrier is soy lecithin and cholesterol. The liposome injection has good preparation stability, the liposome during freeze drying process does not crack caused by dehydration, fusion, ice crystal formation and the like; and likewise, the liposome keeps good encapsulation efficiency after hydration redissolution.

Description

Technical field [0001] The invention relates to an antibiotic liposome preparation, in particular to an amoxicillin sodium and flucloxacillin sodium pharmaceutical composition liposome injection and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Amoxicillin sodium flucloxacillin sodium is a compound antibiotic composed of a ratio of 1:1. Amoxicillin is a semi-synthetic broad-spectrum penicillin, belonging to the class of amino penicillins. It has bactericidal effects on both Gram-negative and positive bacteria. It is characterized by broad-spectrum and penicillinase intolerance. Flucloxacillin is a semi-synthetic isoxazole penicillin, which is not easily destroyed by penicillinase, and has a bactericidal effect on penicillinase-producing drug-resistant Staphylococcus aureus. Mainly used for penicillin-resistant Staphylococcus infections, but Gram-negative bacteria are resistant to flucloxacillin. The antibacterial mecha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/431A61K31/43A61K9/14A61K9/127A61P31/04
Inventor 杨明贵
Owner HAINAN MEILAN SMITH KLINE PHARMA
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