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Method for preparing catalpol and polysaccharide of rehmannia glutinosa libosch from fresh rehmannia glutinosa libosch

A technology of rehmannia polysaccharides and rehmannia, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the problems of low product yield, low utilization rate of rehmannia raw materials, low content, etc., and achieve good effect, The effect of shortening the production cycle and increasing the yield

Inactive Publication Date: 2010-09-01
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In a word, the existing disclosed technology has the following disadvantages: 1. the utilization rate of rehmannia glutinosa raw materials is not high; 2. the product yield is low or the content is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Wash fresh Rehmannia glutinosa (0.8% catalpol content) with water, cut into thin slices, take 50kg, put it into an extraction tank, add 200L of 95% ethanol, reflux extraction for 2 hours, filter the liquid with suction, add 1kg of activated carbon for decolorization for 2 hours, and filter to obtain liquid A (mainly containing catalpol); then extracted twice with water, adding 200kg of water each time, the temperature was 90°C, the extraction time was 2 hours, the combined liquid was decolorized by adding 3kg of activated carbon for 2 hours, and filtered to obtain liquid B.

[0030] Concentrate the liquid B under reduced pressure to a density of 1.3 and release it to obtain 18kg of concentrated liquid, pour it into an alcohol precipitation tank, take 54kg of 95% ethanol, slowly add it and stir it to precipitate, separate the precipitate, and obtain the precipitate and liquid C.

[0031] Dissolve the precipitate in hot water, add 4 times the volume of 95% ethanol to preci...

Embodiment 2

[0034] Wash fresh Rehmannia glutinosa (0.8% catalpol content) with water, cut into thin slices, take 50 kg, put it into an extraction tank, add 250 L of 95% ethanol, reflux for 2 hours, filter the liquid, add 2.5 kg of activated carbon for decolorization for 0.5 hours, and filter to obtain the liquid A (mainly containing catalpol); then extracted with water 3 times, adding 250kg of water each time, the temperature was 80°C, the extraction time was 1 hour, the combined liquid was decolorized by adding 5 kg of activated carbon for 0.5 hour, and filtered to obtain liquid B.

[0035] Concentrate the liquid B under reduced pressure to a density of 1.4 and release it to obtain 19 kg of the concentrated liquid, pour it into an alcohol precipitation tank, take 78 kg of 95% ethanol, slowly add it and stir it to precipitate, separate the precipitate, and obtain the precipitate and liquid C.

[0036] Dissolve the precipitate in hot water, add 4 times the volume of 95% ethanol for precipit...

Embodiment 3

[0039] Wash fresh Rehmannia glutinosa (0.8% catalpol content) with water, cut into thin slices, take 100kg, put it into an extraction tank, add 500L of 95% ethanol, reflux extraction for 2 hours, filter the liquid with suction, add 4kg of activated carbon for decolorization for 1 hour, and filter to obtain liquid A (mainly containing catalpol); water extraction twice, add water 600kg, 500kg, temperature 90°C, extraction time 2 hours, 1 hour, add 10kg activated carbon to the combined liquid for decolorization for 1 hour, filter to obtain liquid B.

[0040]Concentrate the liquid B under reduced pressure to a density of 1.35 and release it to obtain 40 kg of the concentrated liquid, pour it into an alcohol precipitation tank, take 160 kg of 95% ethanol, slowly add it and stir it to precipitate, separate the precipitate, and obtain the precipitate and liquid C.

[0041] Dissolve the precipitate in hot water, add 4 times the volume of 95% ethanol to precipitate, separate the precipi...

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PUM

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Abstract

The invention relates to a method for preparing catalpol and polysaccharide of rehmannia glutinosa libosch from fresh rehmannia glutinosa libosch. In the process, fresh rehmannia glutinosa libosch serving as a raw material is sliced, alcohol extraction of catalpol is performed first, then water extraction of the polysaccharide is performed, alcohol precipitation is performed, the polysaccharide is purified by nano filtration, and the catalpol is obtained by macroporous resin absorption and medium-pressure silica gel column separation. When the method is used for producing the catalpol and the polysaccharide of rehmannia glutinosa libosch, the raw material utilization rate is high; the cost is low; and the process is simple.

Description

Technical field: [0001] The invention relates to an extraction and purification process of catalpol and rehmannia polysaccharide, in particular to a new process for simultaneously preparing catalpol and rehmannia polysaccharide from rehmannia. Background technique: [0002] Rehmannia glutinosa is a perennial herb of the family Scrophulariaceae. Its tuber root human medicine was first recorded in "Shen Nong's Materia Medica" and listed as the top grade. It is a large traditional Chinese medicinal material in my country. Huai Dihuang is an authentic medicinal material. Hemostasis; used for hot wind hurting yin, crimson tongue and polydipsia, spot rash, vomiting blood, epistaxis, sore throat. Radix Rehmanniae clears away heat and cools blood, nourishes yin, and promotes body fluid; it is used for fever, polydipsia, spot rash, internal heat due to yin deficiency, hematemesis, epistaxis, diabetes, and infectious liver. The chemical composition contains catalpol, various amino aci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04C07H1/08C08B37/00
Inventor 刘东锋张翼杨成东
Owner NANJING ZELANG MEDICAL TECH
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