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Tissue engineering artificial tendon scaffold enhanced body and preparation method thereof

A scaffold reinforcement and artificial tendon technology, applied in prosthetics, textiles and papermaking, medical science, etc., can solve the problems of scaffold fragmentation, in vitro construction or graft failure, etc., and achieve convenient operation and use, good biomechanical properties, and high mechanical strength effect of nature

Inactive Publication Date: 2010-09-15
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tissue-engineered tendon scaffolds usually have good biocompatibility, and cells can adhere, proliferate, and secrete extracellular matrix on the scaffolds. However, most scaffolds currently have good cell adhesion but cannot meet the requirements of biodegradation. The mechanical requirements in the process, while the tissue engineering tendon scaffold must bear a certain tensile load no matter in the in vitro construction process or after transplantation in vivo, the degradation rate of the scaffold is too fast, which will cause the scaffold to be stretched before the tissue is formed Fragmentation after loading, resulting in eventual failure of in vitro constructs or grafts

Method used

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  • Tissue engineering artificial tendon scaffold enhanced body and preparation method thereof
  • Tissue engineering artificial tendon scaffold enhanced body and preparation method thereof
  • Tissue engineering artificial tendon scaffold enhanced body and preparation method thereof

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0028] (1) Preparation of braided wire: 4 strands of PGA multifilament with a linear density of 0.43tex and 2 strands of PLA multifilament with a linear density of 0.56tex (the mixing ratio of PGA and PLA is 60:40), at a temperature of 20°C , Under the atmospheric condition of relative humidity 65%, carry out coreless cross weaving into yarn on 12 vertical spindle knitting machines, braiding angle 54.5 °.

[0029] (2) Preparation of tissue-engineered artificial tendon scaffold reinforcement: use crochet needles with braided needles as mesh edges, 30 stitches, and a loop diameter of 10 mm. Knit the mesh circular fabric with braided needles and short needles, with 6 braided needles and a length of 40mm, then narrow the needles.

[0030] (3) Preparation of tissue engineering artificial tendon scaffold: 20 mg of PGA fibers (15 microns in diameter) were filled into the tissue engineering scaffold reinforcement to form a tissue engineering tendon scaffold with a length of 40 mm and ...

Embodiment 2

[0032] (1) Preparation of strands: PGA monofilament with a linear density of 18dtex and PLA monofilament with a linear density of 4.5dtex (the mixing ratio of PGA and PLA is 80:20), at a temperature of 20°C and a relative humidity of 65%. Under atmospheric conditions, they are plied into strands on the doubling machine.

[0033] (2) Preparation of tissue-engineered artificial tendon scaffold reinforcement: use crochet needles with braided needles as mesh edges, 40 stitches, and a loop diameter of 12 mm. Knit the mesh circular fabric with braided needles and short needles, 10 braided needles, 50mm in length, and narrow the needles.

[0034] (3) Preparation of tissue-engineered artificial tendon scaffold: 30 mg of PGA fibers (15 microns in diameter) were filled into the tissue-engineered scaffold reinforcement to form a tissue-engineered tendon scaffold with a length of 50 mm and a diameter of 10 mm, and the porosity of the PGA fibers was 86%.

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Abstract

The invention relates to a tissue engineering artificial tendon scaffold enhanced body which comprises tube-shaped fabrics. The tube-shaped fabrics are braided by interweaving PGA (Polyglycolic Acid) fiber flaments and PLA (Polylactic Acid) fiber flaments or PGLA (Poly (Lactic-glycolic Acid)) fiber flaments on a spindle machine to form braided wires or combining the fiber flaments to cord yarns and are in a hollow circular reticular tissure structure. A preparation method of the tissue engineering artificial tendon scaffold enhanced body comprises the following steps of braiding the PGA (Polyglycolic Acid) fiber flaments and the PLA (Polylactic Acid) fiber flaments or the PGLA (Poly (Lactic-glycolic Acid)) fiber flaments into wires or the cord yarns, braiding the wires or the cord yarns into a ring by withdrawing a braiding needle, braiding edges of the reticular structure by the braiding needle, and connecting the edges by short needles. The enhanced body can enable cells to grow in an attaching mode, has the advantage of controllable degradation rate of a scaffold, simple and rapid preparation method and the like, particularly and still has higher mechanical property in the degradation process of the scaffold and has favorable application prospect, wherein the mechanical disintegration rate is matched with the tendon tissue growth rate, and the length of the scaffold can be arbitrarily shorn as required. The invention has favorable application prospect.

Description

technical field [0001] The invention belongs to the field of artificial tendon support auxiliary materials and the preparation thereof, in particular to a tissue engineering artificial tendon support reinforcement and a preparation method thereof. Background technique [0002] Tendon injury is one of the common injuries in sports people. There are certain limitations or deficiencies in the current treatment methods. The birth and development of tissue engineering technology provides a more ideal and physiological method for clinical tendon repair. Using tissue engineering technology to repair tendon defects is to obtain a small amount of tendon seed cells, culture and expand them in vitro, combine them with biodegradable scaffolds to form a complex, implant them into the defect site, and then seed cells proliferate, differentiate, and secrete matrix to form a repair tissue. , biomaterials gradually degrade, and finally achieve complete repair in the biological sense. Amon...

Claims

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Application Information

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IPC IPC(8): A61L27/26A61L27/18D02G3/02D02G3/04
Inventor 张佩华郯志清蔡俊瑶陈南梁刘伟沈新元邓丹杨庆王文祖郭正陈思诗唐乃杰
Owner DONGHUA UNIV
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