Micro-needle array chip and percutaneous administration patch using same and preparation method thereof

A technology of microneedle array and chip, which is applied in the direction of microneedles, medical formulas, needles, etc., can solve the problems of low cost, achieve low cost, facilitate puncture, and facilitate diffusion and absorption

Active Publication Date: 2010-09-15
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Metals have been used to manufacture acupuncture needles or injection needles for thousands of years. Although their safety is unquestionable, it is difficult to process solid and hollow metal microneedle array chips at low cost and in large quantities using traditional precision processing methods.

Method used

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  • Micro-needle array chip and percutaneous administration patch using same and preparation method thereof
  • Micro-needle array chip and percutaneous administration patch using same and preparation method thereof
  • Micro-needle array chip and percutaneous administration patch using same and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Microneedle array chip and its preparation method

[0094] The microneedle array chip includes a microneedle and a substrate 4. The microneedle is composed of a needle head 1, a needle bar 2 and a needle seat 3. The top of the needle head is a needle point 5. The microneedle is fixed on the substrate 4 through the needle seat 3. The needle bar 2 and the needle seat 3 is a cylinder or a cone, and the microneedles are vertically fixed on the substrate 4, such as Figure 1-Figure 3 As shown, the needle head 1 is conical; or the microneedle is fixed on the substrate 4 at an inclined setting angle, and the setting angle is preferably 20-160 degrees, such as Figure 4-Figure 9 , Figure 12-Figure 14 with Figure 16-Figure 17 As shown, there is an elliptical plane parallel to the substrate 4 or inclined at a set angle at the needle head, so there is an elliptical plane needle tip 5 or the edge of the elliptical plane needle tip is further processed so that there are more sha...

Embodiment 2

[0117] Fabrication of Solid or Hollow Stainless Steel Microneedle Array Chips

[0118] Insert stainless steel solid needles or hollow needles with an outer diameter of 300 microns vertically or obliquely or penetrate the methyl methacrylate prepolymer solution with a thickness of 2 mm for the preparation of polymethyl methacrylate substrates at a set interval, The needles need to protrude from the substrate by a certain height, and after heating, polymerization and curing, the prototype of the microneedle array chip is formed. Cut off the needle bar or needle tube exposed on the bottom side of the substrate, and push the needle bar to adjust the angle between it and the substrate as needed, and finally form a Figure 1-3 , solid as shown in 10, 11 or as Figure 5 , 9 , 14, and 15 shown hollow stainless steel microneedle array chips.

Embodiment 3

[0120] Fabrication of Solid or Hollow Stainless Steel Microneedle Array Chips

[0121] A stainless steel solid rod or hollow tube with an outer diameter of 300 microns is inserted into each hole of the through-hole array mold, and then these rods or tubes are inserted or penetrated at an angle with a thickness of 2mm for the preparation of polymethacrylic acid In the methyl methacrylate prepolymer solution of the methyl ester substrate, after thermal polymerization and curing, these rods or tubes are cut off at a distance of 0.5 to 8 mm from the substrate to form a prototype of a solid rod or hollow tube array chip, such as Figure 23A shown. If hollow microneedles are to be manufactured, the tube or substrate on the bottom side of the substrate of the chip must be smoothed to ensure that all tubes are exposed on the surface of the substrate on this side; the stainless steel rod or tube on the other side can be pushed to adjust its relationship with the substrate as required ...

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Abstract

The invention discloses a micro-needle array chip, which comprises a micro-needle and a substrate. The micro-needle consists of a needle head, a needle rod and a needle base; the top of the needle head is provided with a needle point; the micro-needle is fixed on the substrate through the needle base; the needle rod of the micro-needle is cylindrical or conical; the needle rod is inclined to the substrate at a set angle; and the needle head is conical or the upper surface of the needle point is an elliptical plane which is parallel to the substrate or inclined to the substrate at a set acute angle. The metal micro-needle in the micro-needle array chip is firm in structure and cannot rupture; the needle point is sharp and convenient to puncture; the maximum puncture depth of the micro-needle is easily regulated and controlled; the micro-needle in the array has good consistency and are safe and reliable to use; and the hollow micro-needle has a side opening similar to that of the traditional needle. Therefore, the micro-needle array chip can effectively avoid the phenomenon that the skin blocks the infusion hole, is more favorable for rapid diffusion and absorption of medicaments, and has obvious curative effect.

Description

[0001] This application claims the priority of the Chinese patent application with the filing date of March 27, 2009 and the application number of 200910080758.X. technical field [0002] The invention relates to the technical fields of medical and beauty equipment, biomedicine and microfabrication, in particular to a microneedle array chip, a transdermal drug delivery device, a transdermal drug delivery patch, a microneedle array electrode and a preparation method. Background technique [0003] The therapeutic effect of a drug not only depends on the drug itself, but the drug delivery system also has a very important impact on the efficacy of the drug. For biomacromolecular drugs such as peptides, proteins, DNA, and vaccines represented by insulin, due to the degradation of enzymes in the gastrointestinal tract and the first-pass effect of the liver, the bioavailability of oral administration is very low and the curative effect cannot be achieved. . Subcutaneous injection ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61M35/00A61F13/02
CPCA61M2037/0046A61M37/0015A61K9/0021A61M2037/0053A61M2037/0023Y10T29/49826Y10T156/1062
Inventor 岳瑞峰王燕
Owner TSINGHUA UNIV
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