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Post-treatment method of flavomycin

A flavomycin and solution technology, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the problems of long production cycle, low yield, high energy consumption of production process, etc., and shorten the production cycle , improved yield, and easy operation

Active Publication Date: 2010-09-15
ZHEJIANG QIANJIANG BIOCHEMICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used flavomycin post-treatment production process is to use the method of directly spraying and drying the fermentation liquid to produce flavomycin premix. This production process consumes a lot of energy, has a long production cycle and low yield.

Method used

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  • Post-treatment method of flavomycin
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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] In 10 tons of flavomycin fermentation broth, first add 120kg 1mol / L Na 2 HPO 4 , then add 80kg1mol / L CaCl 2 , stirring with air to dissolve and flocculate the fermentation broth, and then adjust the pH to 5.8 with 2N NaOH solution, then raise the temperature of the jacket to 70°C and stand still for 15 minutes. Use a plate and frame press filter, and the filter residue is boiled and dried. The boiling drying temperature is controlled at the air inlet of 100°C, and the outlet temperature is controlled at 60°C; Controlled at 80°C. A total of 1165 kg of boiling-dried and spray-dried objects were obtained, with a yield of 88.5% and a loss on drying of 3.3%.

Embodiment 2

[0015] In 10 tons of flavomycin fermentation broth, first add 120kg 1mol / L Na 2 HPO 4 , then add 80kg1mol / L CaCl 2 , stirring with air to dissolve and flocculate the fermentation broth, and then adjust the pH to 6.0 with 2N NaOH solution, then raise the temperature of the jacket to 70°C and stand still for 20 minutes. Use a plate and frame press filter, and the filter residue is boiled and dried. The boiling drying temperature is controlled at the air inlet of 110°C, and the outlet temperature is controlled at 70°C; Controlled at 90°C. A total of 1198 kg of boiling-dried and spray-dried materials were obtained, with a yield of 89.5% and a loss on drying of 3.8%.

Embodiment 3

[0017] In 10 tons of flavomycin fermentation broth, first add 120kg 1mol / L Na 2 HPO 4 , then add 80kg1mol / L CaCl 2 , stirring with air to dissolve and flocculate the fermentation broth, and then adjust the pH to 6.2 with 2N NaOH solution, then raise the temperature of the jacket to 70°C and stand still for 30 minutes. Use plate and frame filter press, filter residue boiling drying, boiling drying temperature is controlled at the air inlet 120 ℃, outlet temperature is controlled at 80 ℃. The filtrate is concentrated in a scraper thin-film evaporator and then spray-dried. The temperature of the spray-drying is controlled at 200°C at the air inlet and at 100°C at the outlet. A total of 1187 kg of boiling-dried and spray-dried materials were obtained, with a yield of 89.2% and a loss on drying of 3.7%.

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Abstract

The invention relates to a post-treatment method of flavomycin. The flavomycin is phosphoric acid polysaccharide antibiotic and is mainly used for promoting the growth of livestock and poultry. The traditional post-treatment production process of flavomycin adopts a method of directly spray drying fermentation liquor to make a flavomycin premixing agent and has high energy consumption, long cycle and low yield. In the invention, the post-treatment method comprises the following steps of: adding sodium hydrogen phosphate and calcium chloride solution into flavomycin fermentation liquor, flocculating and extruding the fermentation liquor, boiling and drying wet residues, concentrating through a filtrate scrapper thin-film evaporator, spray drying, then mixing, preparing and packaging. The invention greatly reduces the energy consumption, shortens the production cycle and improves the yield.

Description

technical field [0001] The invention belongs to the technical field of biochemical industry, and in particular relates to a post-treatment method of phosphopolysaccharide antibiotic flavomycin. Background technique [0002] Flavomycin is a phosphate polysaccharide antibiotic, mainly used to promote the growth of livestock and poultry. Flavomycin can interfere with the biosynthesis of peptidoglycan, a structural substance that makes up the cell wall, causing cell rupture and inhibiting bacterial reproduction. Flavomycin has a strong effect on Gram-positive bacteria, has a certain effect on Gram-negative bacteria, and has no effect on fungi and viruses. Flavomycin can also thin the intestinal wall, improve digestion and absorption, promote the growth of livestock and poultry, improve production performance and feed remuneration. Flavomycin is hardly absorbed, excreted quickly, has low toxicity, and is not easy to cause drug residues and drug resistance. At present, the comm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H13/12C07H1/06
Inventor 裘国寅姚萍华常宏
Owner ZHEJIANG QIANJIANG BIOCHEMICAL CO LTD