Water-soluble micro powder containing florfenicol and preparation method thereof
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A technology of florfenicol and compound florfenil, which can be applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, powder delivery, etc. Problems such as breeding farms, to achieve the effect of simple methods
Active Publication Date: 2010-09-29
山东迅达康兽药有限公司
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Problems solved by technology
Chloramphenicol, the prodrug of Florfenicol, is currently banned in food-producing animals due to its ability to cause severe aplastic anemia
As one of the few veterinary antibacterial drugs, Florfenicol has a wide application prospect, but due to its poor water solubility, the drug itself is inconvenient to use in large-scale farms, which has great restrictions on its use
[0003] The currently used solution-assisting method, due to the use of a ver
Method used
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Embodiment 1
[0020] For example, to produce 100kg of water-soluble micropowder containing florfenicol, 5kg of florfenicol, 2.5kg of PVPK30, 2.5kg of SDS, mix evenly, pulverize, pass through a 150 mesh sieve, add 90kg of anhydrous glucose to mix, and increase in equal amounts Mix well to make. The effects of this water-soluble micronized powder containing florfenicol on broiler chickens are as follows:
[0021] 1. Test animals:
[0022] 90 broiler chickens suffering from E. coli disease were randomly selected and randomly divided into 3 groups, 30 in each group, with a body weight of 1-2 kg.
[0023] 2. Experimental drugs:
[0024] The water-soluble micropowder containing Florfenicol prepared in Example 1 of the present invention;
[0025] 5% florfenicol powder: 5% florfenicol by mass and 95% starch by mass are uniformly mixed.
[0026] 3. Experimental method:
[0027] Group 1 was a blank control group without any drugs.
[0028] 2 groups were treated with 5% florfenicol powder. Usage...
Embodiment 2
[0042] Such as producing 100kg water-soluble compound florfenicol micropowder, 5kg florfenicol, 2.5kg PVPK30, 2.5kgSDS, 5kg quinolones (norfloxacin), mix evenly, pulverize, pass through a 150 mesh sieve, add 85kg of nonfloxacin Made with water glucose mix.
Embodiment 3
[0044] For example, to produce 100kg of water-soluble micropowder containing florfenicol, 10kg of florfenicol, 2.6kg of PVPK30, 2.6kg of SDS, mix well, pulverize, pass through a 150 mesh sieve, add 84.8kg of anhydrous glucose to mix, equal amount Incremental mixing is made evenly.
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Abstract
The invention discloses a water-soluble micro powder containing florfenicol and a preparation method thereof. The micro powder is prepared from the following raw materials in percentage by weight: 5 to 10 percent of florfenicol, 2.5 to 2.75 percent of PVPK30, 2.5 to 2.75 percent of SDS and the balance anhydrous glucose. PVPK30, SDS and florfenicol are mixed uniformly, crushed, pass through a 150mesh screen, and then are added with the anhydrous glucose to be mixed uniformly. The micro powder also can be combined with other medicines to prepare water-soluble compound florfenicol micro powder. The grain size of the florfenicol through micro powder treatment is finer and more uniform, so the surface area is increased, the porosity is increased, the absorbability and the solubility are improved, the medicines can be well dispersed and dissolved in gastric juice, the contact area with gastric mucosa is enlarged, so that the medicines can be absorbed by the gastrointestinal tract more easily, thereby greatly improving the bioavailability. The preparation method is more convenient than a coating process, and is more applicable to large-scale production.
Description
technical field [0001] The invention relates to a water-soluble micropowder containing florfenicol and a preparation method thereof, belonging to the technical field of veterinary medicine. Background technique [0002] Florfenicol (Florfenicol) Chinese name: fluprofen, florfenicol, florfenicol, is a new veterinary-specific broad-spectrum antibacterial drug of chloramphenicol successfully developed in the late 1980s. It was first launched in Japan in 1990. In 1993, Norway approved the drug to treat salmon furunculosis. In 1995, France, the United Kingdom, Austria, Mexico and Spain approved it to treat bovine respiratory system bacterial diseases. It is also approved as a feed additive for pigs in Japan and Mexico to prevent and treat bacterial diseases of pigs (Qiu Yinsheng et al., 1996). my country has passed the approval of this drug at present. Florfenicol has a good antibacterial effect on Gram-positive bacteria and Gram-negative bacteria in livestock and poultry, and i...
Claims
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Application Information
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