Water-soluble micro powder containing florfenicol and preparation method thereof

Abstract

The invention discloses a water-soluble micro powder containing florfenicol and a preparation method thereof. The micro powder is prepared from the following raw materials in percentage by weight: 5 to 10 percent of florfenicol, 2.5 to 2.75 percent of PVPK30, 2.5 to 2.75 percent of SDS and the balance anhydrous glucose. PVPK30, SDS and florfenicol are mixed uniformly, crushed, pass through a 150mesh screen, and then are added with the anhydrous glucose to be mixed uniformly. The micro powder also can be combined with other medicines to prepare water-soluble compound florfenicol micro powder. The grain size of the florfenicol through micro powder treatment is finer and more uniform, so the surface area is increased, the porosity is increased, the absorbability and the solubility are improved, the medicines can be well dispersed and dissolved in gastric juice, the contact area with gastric mucosa is enlarged, so that the medicines can be absorbed by the gastrointestinal tract more easily, thereby greatly improving the bioavailability. The preparation method is more convenient than a coating process, and is more applicable to large-scale production.

Description

technical field [0001] The invention relates to a water-soluble micropowder containing florfenicol and a preparation method thereof, belonging to the technical field of veterinary medicine. Background technique [0002] Florfenicol (Florfenicol) Chinese name: fluprofen, florfenicol, florfenicol, is a new veterinary-specific broad-spectrum antibacterial drug of chloramphenicol successfully developed in the late 1980s. It was first launched in Japan in 1990. In 1993, Norway approved the drug to treat salmon furunculosis. In 1995, France, the United Kingdom, Austria, Mexico and Spain approved it to treat bovine respiratory system bacterial diseases. It is also approved as a feed additive for pigs in Japan and Mexico to prevent and treat bacterial diseases of pigs (Qiu Yinsheng et al., 1996). my country has passed the approval of this drug at present. Florfenicol has a good antibacterial effect on Gram-positive bacteria and Gram-negative bacteria in livestock and poultry, and i...

AI Technical Summary

Problems solved by technology

Chloramphenicol, the prodrug of Florfenicol, is currently banned in food-producing animals due to its ability to cause severe aplastic anemia

As one of the few veterinary antibacterial drugs, Florfenicol has a wide application prospect, but due to its poor water solubility, the drug itself is inconvenient to use in large-scale farms, which has great restrictions on its use

[0003] The currently used solution-assisting method, due to the use of a very complicated production process, causes an increase in use costs, and is not suitable for large-scale farms, and the current solution-assisted method causes the release rate of florfenicol itself to slow down in the intestinal tract. The digestive system of poultry is short, and the time it takes for the drug to pass through the entire system is relatively short, which reduces the absorption and effect of the drug, resulting in waste of the drug