Auxiliary material combination for improving atomizing and drying process of traditional Chinese medicine granules and application thereof

Abstract

The invention relates to an auxiliary material combination for improving atomizing and drying process of traditional Chinese medicine granules and an application thereof. The auxiliary material combination comprises 10 to 90 percent of betadex and 10 to 90 percent of maltodextrin or dextrine. The application of the auxiliary material combination is: after being dissolved in hot water, the auxiliary material combination is added into extract obtained by extracting Chinese medicine or is directly added into extract to be uniformly mixed and to be atomized and dried; when adding the auxiliary material combination, the temperature of the extract is 50 to 100 DEG C, relative density of the extract is 1.02 to 1.20 (60 DEG C), air inlet temperature for atomizing drying is 140 to 190 DEG C, and the air outlet temperature is 75 to 100 DEG C. by adopting the auxiliary material combination, under the same atomizing and drying condition, the consumed quantity of the auxiliary material is less, the consumption quantity of the auxiliary material can be reduced by more than 30 percent, the auxiliary material with the same quantity is added for atomizing and drying, the softening point of the extract can be improved during the atomizing and drying process, the wall is difficult to be adhered during the atomizing process, the fluidity of the atomizing and drying powder is good, the atomizing and drying powder is difficult to be moistened, the dispersion of the flavor can be effectively prevented during the atomizing and drying process, and the original flavor of the extract is maintained.

Description

technical field [0001] The invention relates to the technical field of production of traditional Chinese medicine formula granules, in particular to an auxiliary material combination for improving the spray drying process of traditional Chinese medicine formula granules and its application, belonging to the technical field of traditional Chinese medicine production. Background technique [0002] Traditional Chinese medicine formula granules are made of traditional Chinese medicine decoction pieces as raw materials, which are extracted, separated, concentrated, dried, and granulated to make single-flavor preparations. It is a new dosage form that replaces decoction pieces for clinical prescriptions. [0003] During the clinical use of traditional Chinese medicine formula granules, a doctor usually has more than a dozen medicines in a prescription. If the amount of excipients in each medicine is not reasonably and effectively controlled in the process design, the total amount o...

AI Technical Summary

Problems solved by technology

[0004] In the production process of traditional Chinese medicine formula granules, in order to prevent the powder from sticking to the wall during the spray drying stage and affecting the production, it is necessary to add a large amount of excipients to overcome it, especially a type of sugar-containing Chinese medicine, such as wolfberry, jujube, Codonopsis pilosula, etc. , this type of traditional Chinese medicine contains a lot of sugar, which is mainly used clinically to nourish, enhance physical fitness, and improve disease resistance. Therefore, the sugar contained in this type of traditional Chinese medicine is also the main active ingredient, which should be effectively preserved in the preparation process. However, this Traditional Chinese medicines with high sugar content have several characteristics: 1. The dissolution rate of sugar in water is large, and the extract obtained by water extraction is more, that is, the extraction rate is high, and the production volume is large without adding auxiliary materials

2. The high sugar content leads to a low softening point during the drying process of the extract. Taking medlar as an example, the softening point is about 60-70°C without adding auxiliary materials. When the drying temperature is higher than the softening point, the extraction The particles stick together and cannot form powder, which leads to difficulty in drying. During the spray drying process, it is shown as sticking to the wall, that is, the particles after the water evaporates remain in a softened state in the drying tower with a higher temperature. Adheres to the tower wall, forming a maltose-like paste, unable to form a powder

However, although this method of adding a large amount of excipients solves the process problem, for traditional Chinese medicine formula granules, this will lead to excessive addition of excipients, and the finished product will not only fail to achieve the purpose of concentration, but will greatly increase the dosage of patients. , does not conform to the process design principles of traditional Chinese medicine formula granules

[0006] In addition, this type of traditional Chinese medicine generally has its own unique aroma. However, during the spray drying process, the extract is sprayed into a mist, and under the action of high-temperature airflow, the addition of conventional auxiliary materials is only to ensure normal spray drying, but it cannot be used. effectively retain the aroma of traditional Chinese medicine, and the aroma of traditional Chinese medicine is lost in a large amount. Therefore, the smell of the finished product is relatively weak