Industrial preparation method of pantoprazole intermediate pyridine hydrochloride
A technology of pyridine hydrochloride and pantoprazole, applied in the field of medicine, can solve the problems of high cost, unfavorable industrial production, low yield and the like, and achieve the effects of easy handling, low price and cost reduction
Inactive Publication Date: 2010-11-03
南京元德新材料科技有限公司
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The invention discloses an industrial preparation method of pantoprazole intermediate pyridine hydrochloride, including the following steps: (1) preparation of 3-methoxy-2-methyl-4H-pyran-4-ketone; (2) preparation of 3-methoxy-2-methyl-4(1H)-pyridone; (3) preparation of 4-chlorine-3-methoxy-2-methylpyridine; (4) preparation of 4-chlorine-3-methoxy-2-methylpyridine-N-oxide; (5) preparation of 3, 4-dimethoxy-2-methylpridine-N-oxide; (6) preparation of 2-hydroxymethyl-3, 4-dimethoxyprindine; (7) preparation of 2-chloromethyl-3, 4-dimethxyl pyridine hydrochloride. In the invention, the reactions in the steps are all carried out under atmospheric pressure while temperature is lower than 100 DEG C, condition is mild, thus being safe and reliable; besides, the raw materials adopted in the invention are all low in price and high in utilization ratio, and multiple raw materials can be used repeatedly, thus reducing cost; and the quality of the obtained product can reach more than 98%, thus completely meeting the requirement; in addition, waste gas and waste water which are produced in the steps are easy to be treated, thus being applicable to industrialized production.
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Classification and recommendation of technical efficacy words
- Low price
- Mild conditions