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Method for extracting and purifying Pinostrobin from medicinal plants, and pharmaceutical preparation and application thereof

A technology for medicinal plants and pharmaceutical preparations, applied in the field of life sciences, can solve the problems of excessive use of toxic solvents and cumbersome operations, and achieve the effects of efficient resource utilization, simple extraction and purification operations, and difficulty in secondary drug resistance.

Inactive Publication Date: 2010-11-03
马灵媛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the existing patent (CN1666745A) and (Application No.: 2007101445360) have reported the method of extracting and purifying ballobacham, it has the characteristics of cumbersome operation and the use of many toxic solvents, and there is no report on the treatment of gastrointestinal diseases with ballchafenin preparations.

Method used

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  • Method for extracting and purifying Pinostrobin from medicinal plants, and pharmaceutical preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1. Preparation of Condominin Extract from the Peel of Hickory Nut

[0022] Take the fresh pecan fleshy peel, put it in a homogenate extractor, add 10 times the amount of ethanol with a concentration of 90%, homogenize twice at a high speed, 1 minute each time, filter the extract, combine the filtrate, concentrate under reduced pressure and recover ethanol (60°C, 0.09Mpa) until the relative density of the extract is 1.12, let it stand still for 20 minutes, remove the supernatant, and obtain the extract whose precipitate is ballocchinin.

Embodiment 2

[0023] Example 2. Preparation of Coneconolin Extract from the Root of Saffron

[0024] Take the dried root, remove impurities, slice, add 5 times the amount of water to soak for 24 hours, then place it in a tissue homogenate extractor, add 15 times the amount of ethanol with a concentration of 90%, and homogenize at high speed for 3 times, Each time for 5 minutes, filter the extract, combine the filtrate, concentrate under reduced pressure and recover ethanol (60°C, 0.09Mpa) until the relative density of the extract is 1.15, let it stand still for 20 minutes, remove the supernatant, and obtain the extract whose precipitate is ballocchinin .

Embodiment 3

[0025] Example 3. Preparation of Condominin Extract from Oxytropis falciparum Whole Herb

[0026] Take fresh Oxytropis falciparum herb, remove impurities, cut into sections, put it in a tissue homogenate extractor, add 12 times the amount of 80% ethanol, homogenize twice at high speed, each time for 2 minutes, filter the extract, Combine the filtrates, concentrate under reduced pressure and recover ethanol (60°C, 0.09Mpa) to the relative density of the extract 1.10, let it stand still for 20 minutes, remove the supernatant, and obtain the extract whose precipitate is ballocchinin.

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Abstract

The invention relates to a method for extracting and purifying Pinostrobin from medicinal plants, and a pharmaceutical preparation and application thereof. The invention particularly discloses a method for extracting and purifying Pinostrobin from medicinal plants, and a pharmaceutical preparation and application thereof in preparing medicines for treating gastroenteropathy, and belongs to the field of life sciences. The method comprises the following steps: extracting medicinal plants with 70-95% ethanol homogenate; and after the extract is concentrated to a certain volume, standing to precipitate, removing a supernatant, dissolving the obtained precipitate with an organic solvent, separating by gel-resin column chromatography, crystallizing and recrystallizing to obtain the Pinostrobin monomer of which the purity is higher than 90%. The Pinostrobin monomer in which different excipients can be added is prepared into any common pharmaceutical formulation. The pharmaceutical preparation has obvious biological activity on peptic ulcer, gastritis, stomachache, gastric evacuation (gasterectasis), alimentary tract tumors and the like caused by Helicobacter pylori infection, and has thecharacteristic of no toxic or side effect.

Description

Technical field [0001] The present invention involves the field of life sciences, and specifically involves a method of extracting glutin from medicinal plants and its drug preparations and its application in the preparation of gastrointestinal diseases. Background technique [0002] Gastrointestinal disease is a common and multiple diseases in the world today, which seriously endangers human health.In recent years, with the continuous improvement of human living standards, irregular diet, immune dysfunction, pylori infection, and the intake of harmful substances lead to stomach bloating, stomach acid, acute and chronic gastritis, digestive ulcers, and even gastric cancer, etc.Intestinal disease seriously affects human health.At present, clinical treatment of gastrointestinal diseases mainly adopts Chinese medicine preparations and chemical synthetic drugs. These two types of drugs, the former uses a large amount of medication and the clinical effects are slow, and the latter has...

Claims

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Application Information

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IPC IPC(8): C07D311/32C07D311/40A61K31/352A61P31/04A61P1/04A61P35/00
Inventor 马灵媛
Owner 马灵媛
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