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Activated carbon granule of load quantum dots as well as preparation method and application thereof

A technology of activated carbon particles and quantum dots, which is applied in the field of materials and biomedicine, can solve the problems of slow clearance rate and high toxicity of Cd-containing quantum dots, and achieve the effect of reducing toxicity and improving application prospects

Inactive Publication Date: 2010-11-17
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] However, quantum dots contain heavy metals, especially commonly used quantum dots such as CdSe, CdTe and CdSe / ZnS, CdTe / ZnS, CdTe / CdS, CdTe / CdSe and other Cd-containing quantum dots are more toxic and have a slow clearance rate in the body. Point-released heavy metal Cd is a class of carcinogens with a half-life of up to 15 years for elimination in the body

Method used

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  • Activated carbon granule of load quantum dots as well as preparation method and application thereof
  • Activated carbon granule of load quantum dots as well as preparation method and application thereof
  • Activated carbon granule of load quantum dots as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0044] Accurately weigh 60 mg of coconut shell activated carbon powder with an average particle size of 30 nanometers, add it to 6 milliliters of CdTe quantum dot aqueous solution modified with mercaptoethylamine, and the quantum dot concentration is about 1 μm0l / l.

[0045] The mixed solution was divided into 3 equal parts, that is, each part contained 20 mg of activated carbon, placed in 3 closed reactors with polytetrafluoroethylene substrates, and mixed for 2 hours at 40 ° C, 70 ° C and 100 ° C respectively, After natural cooling, centrifuge and wash the precipitate three times with deionized water.

[0046] Under the transmission electron microscope, it was found that most of the activated carbon nanoparticles had adsorbed quantum dots, but the amount of adsorbed quantum dots was small, and the amount of adsorbed quantum dots increased slightly as the temperature increased.

Embodiment 2

[0048] Accurately take 100 mg of coconut shell activated carbon powder with an average particle size of 250 nanometers and 1 micron, add 30 milliliters of polydimethyldiallyl ammonium chloride (0.5% , volume concentration) in an aqueous solution, ultrasonically oscillate for 20 minutes, let stand for 30 minutes, and then centrifuge, and the two precipitates obtained are washed 3 times with deionized water respectively.

[0049] Then, 10 milliliters of CdTe quantum dots with a surface modification of thioglycolic acid at a concentration of about 1 μmol / l were added to the two kinds of precipitates, ultrasonically oscillated for 5 minutes, left to stand for 30 minutes, centrifuged, and the precipitates were washed 3 times with deionized water. Activated carbon particles (nanocomposite particles) loaded with quantum dots once are obtained.

[0050] Then add the polydimethyldiallylammonium chloride aqueous solution containing NaCl and the quantum dot aqueous solution alternately a...

Embodiment 3

[0053] Accurately take 100 mg of woody activated carbon powder and bamboo activated carbon powder with an average particle size of 250 nanometers, add 30 milliliters of polydimethyldiallyl ammonium chloride (0.5 ml) containing NaCl (0.5%, mass concentration) therein. %, volume concentration) aqueous solution, after ultrasonic vibration for 20 minutes, let it stand for 30 minutes, then centrifuge, and the two kinds of precipitates obtained were washed 3 times with deionized water respectively.

[0054] Then, 10 milliliters of CdTe quantum dots with a surface modification of thioglycolic acid at a concentration of about 1 μmol / l were added to the two kinds of precipitates, ultrasonically oscillated for 5 minutes, left to stand for 30 minutes, centrifuged, and the precipitates were washed 3 times with deionized water. The nanocomposite particles with quantum dots adsorbed on the surface of wood activated carbon and bamboo activated carbon respectively were obtained.

[0055] The ...

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Abstract

The invention relates to an activated carbon granule of load quantum dots as well as a preparation method and application thereof. The granule is a nanometer compound particle taking activated carbon as a core and quantum dots as a shell, wherein the grain size of the activated carbon is from 30 nanometers to 1 micrometer, and the quantum dots are attached to the surface of the activated carbon through the electrostatic adherence function. The preparation method comprises the steps of: directly adding the quantum dots into the activated carbon with opposite electric property, or decorating positive charge macromolecules on the surface of the activated carbon; and loading the negatively charged quantum dots on the activated carbon through a layer-by-layer electrostatic adherence method to form the compound particle. The invention has the advantages that the obtained compound particle has multiple functions of photodynamic therapy, photoinduced thermal therapy, pigmentation, imaging, and the like, the toxicity of the quantum dots can be reduced, the metabolic pathway and speed of the quantum dots in bodies can be changed, and the application potential of the quantum dots in the medical field can be improved.

Description

technical field [0001] The invention belongs to the field of materials and biomedicine, and relates to the application of quantum dots, especially a kind of activated carbon particles loaded with quantum dots and its preparation method and application. At the same time as the metabolic pathway and rate in the body, it exerts the dual functions of quantum dots and activated carbon. Background technique [0002] Both activated carbon and quantum dots have important applications in biomedicine. [0003] Activated carbon has strong adsorption properties, can load drugs, and has the function of slow-release drugs. Activated charcoal can also be used as a stain, such as for lymph node tracing in tumor sentinel lymph node biopsies. In addition, activated carbon can generate heat rapidly under laser irradiation, and can be used for hyperthermia of tumors. Activated carbon has good biocompatibility and almost no toxicity, so it can be used clinically. [0004] For quantum dots, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K33/24A61K41/00A61K47/04A61P35/00
Inventor 储茂泉周厚森
Owner TONGJI UNIV
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