Unlock instant, AI-driven research and patent intelligence for your innovation.

Degradable biological hydrogel and preparation method thereof

A hydrogel and biological technology, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and pharmaceutical sciences, can solve problems such as poor mechanical strength and slow response speed, and achieve the effect of improving mechanical strength and response speed.

Inactive Publication Date: 2012-07-04
XIAMEN UNIV
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The fatal constraints of hydrogels, especially natural hydrogels, in practical applications are mainly their slow response speed and poor mechanical strength.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Degradable biological hydrogel and preparation method thereof
  • Degradable biological hydrogel and preparation method thereof
  • Degradable biological hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]1) Chitosan with 95% deacetylation degree and 500,000 molecular weight is dissolved in 2% (w / w) dilute acetic acid aqueous solution to obtain 3% (w / w) chitosan solution, and PEGLM (6KL7) is dissolved to 2 % (w / w) dilute acetic acid in water to give a 10% (w / w) solution of PEGLM (6KL7). Weigh 1.00 g chitosan solution and 2.70 g PEGLM (6KL7) solution according to chitosan: PEGLM (6KL7) mass ratio of 1:9, stir and mix.

[0034] 2) Weigh 0.55 g of polyethylene glycol 1000 in an amount of 0.15 g / mL, add it into the mixed solution in step 1), and stir to completely dissolve the polyethylene glycol.

[0035] 3) Add 27 μL of 10% ethanol solution of 2,2-dimethyl-2-phenylacetophenone to the mixed solution in step 2), and stir until the system is evenly mixed. Vacuumize the mixed solution to defoam, and finally blow nitrogen into the system to remove oxygen in the system.

[0036] 4) Under ice-bath conditions, add 0.24 mL of 5% glutaraldehyde aqueous solution to the mixed solutio...

Embodiment 2～7

[0042] Examples 2-7: The reaction conditions are the same as in Example 1, except that the mass ratio of chitosan, PEGLM species, chitosan and PEGLM, chitosan crosslinking agent, and porogen consumption are changed. The results are shown in Table 1.

[0043] Table 1

[0044]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
compressive strengthaaaaaaaaaa
degree of polymerizationaaaaaaaaaa
degree of polymerizationaaaaaaaaaa
Login to View More

Abstract

The invention discloses a degradable biological hydrogel and a preparation method thereof, and relates to a hydrogel. The invention provides a quick-response and high-strength degradable biological hydrogel and a preparation method thereof, which can be applied in the field of biological medicaments. The degradable biological hydrogel is a double-network hydrogel having a porous structure, wherein a chitosan hydrogel is the first network; a polylactic acid-polyethylene glycol-polylactic acid block copolymer hydrogel blocked by a acrylate group is the second network; the mass ratio of the chitosan to the PEGLM is 1:(4-19); and the degradable biological hydrogel is prepared by a stepwise interpenetrating technique. The prepared hydrogel has the porous structure and provides a convenient channel for water and other substances, so the response speed of the gel is improved and swelling equilibrium can be achieved in 9 minutes. The double-network hydrogel is formed through the interpenetrating cooperation of rigid and flexible networks, so the mechanical strength of the gel is improved greatly, and the compressive strength of the gel can reach a maximum value of 1.08 MPa under the condition that the water content is more than 90 percent.

Description

technical field [0001] The invention relates to a hydrogel, in particular to a degradable biological hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a cross-linked network composed of hydrophilic polymers that can swell in water and retain a large amount of water without being dissolved. They can swell to an equilibrium volume in water, and dehydrate and deswell under certain conditions (temperature, pH, ion concentration, electric field and other external stimuli). They are a kind of polymer functional materials integrating water absorption, water retention and controlled release. . Hydrogel is similar to living tissue materials, and its surface adhesion to proteins and cells is very weak. When in contact with blood, body fluids and human tissues, it shows good biocompatibility and does not affect the metabolic process of living organisms. The product can in turn be expelled through the hydrogel. The hydrogel is similar in nature to t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08L67/07C08L5/08C08J3/24C08J9/26C08J3/075A61L15/62A61L15/42A61L15/28A61L15/26A61L27/60A61L27/20A61L27/18A61L27/52A61L27/56A61K47/34A61K47/36A61K9/06
Inventor 戴李宗刘艳玲林苏娟邓胡军许一婷
Owner XIAMEN UNIV