Forecasting method of treating effect of interferon on treating chronic hepatitis B

Abstract

The invention relates to a forecasting method of the treating effect of interferon on chronic hepatitis B. The forecasting method comprises the following steps of: collecting information related to chronic hepatitis B patients; inputting treatment outcome influencing factors of the patients; dividing the treating effect evaluation into three classes; determining specific scores of all levels of the influencing factors by taking the influencing factors as independent variable and the treating effect as dependent variable and building a rating scale and a model; randomly dividing collected illness cases into a training set and a test set, building a rating scale and a model by taking the training set as a sample, and detecting the accuracy of the rating scale and the model by taking the test set as a sample; taking the Youden index which is shown as a formula: sensitivity+specificity-1 as the evaluation index of the rating scale and the accurate model performance, and when the Youden index takes a maximum value, prompting that the forecasting performance is optimal; and enabling the forecasting performance to be optimal by adjusting parameters of mutation rate, mating rate, sub-algebra generation, and the like of a genetic algorithm as well as parameters of kernel training parameters, outlier penalty coefficients, and the like of a support vector machine.

Description

technical field [0001] The invention relates to an interferon, in particular to a method for predicting the curative effect of the interferon in treating chronic hepatitis B (chronic hepatitis B, CHB). Background technique [0002] CHB is caused by hepatitis B virus (hepatitis B virus, HBV) infection. CHB is one of the most threatening diseases to human beings, and interferon and nucleoside (acid) analogs are its two main means. There are many factors affecting the curative effect, long course of treatment, high cost, and both advantages and disadvantages are the important characteristics of antiviral treatment. Before initiating antiviral therapy, two key questions must be clarified: whether a particular patient needs antiviral therapy, and which antiviral regimen may benefit more. Both of these issues are extremely challenging for physicians and patients. According to the report of the World Health Organization, there are 350 to 400 million HBV carriers and chronic infe...

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for predicting the curative effect of interferon in the treatment of chronic hepatitis B with simple operation, convenient use and accurate results in view of the many factors affecting the curative effect of interferon and the difficulty of objectively and quantitatively evaluating the curative effect of interferon.

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