Nucleic acid aptamer for classification of different-subtype non-small cell lung cancers and screening method thereof

A nucleic acid aptamer and cell technology, applied in biochemical equipment and methods, individual particle analysis, material excitation analysis, etc., can solve the problems of insufficient specificity and sensitivity
CN101914543BInactive Publication Date: 2012-04-18INST OF CHEM CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF CHEM CHINESE ACAD OF SCI
Publication Date
2012-04-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a nucleic acid aptamer for classification of different-subtype non-small cell lung cancers and a screening method thereof. The nucleic acid aptamer provided by the invention is a DNA segment which comprises nucleotide shown as any one of sequences 1 to 9 in a sequence table. The nucleic acid aptamer can be applied to the classification of the different-subtype non-small cell lung cancers. By using the nucleic acid aptamer of the invention, the differentiation of the different-subtype non-small cell lung cancers can be realized on a molecular response signal under the condition that tumor markers of the non-small cell lung cancers are unknown. When used for identifying a target combined with the nucleic acid aptamer, the nucleic acid aptamer is favorable for findingout the tumor markers of the different-subtype non-small cell lung cancers, performing earlier diagnosis and more accurate classification of the non-small cell lung cancers and finding out new medicament acting target points for tumor therapy.
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Description

[0001] This application is a divisional application with an application number of 200910083075.X, an application date of April 28, 2009, and an invention titled "nucleic acid aptamers and screening methods for different subtypes of non-small cell lung cancer". technical field

[0002] The invention relates to a nucleic acid aptamer for typing different subtypes of non-small cell lung cancer and a screening method thereof. Background technique

[0003] Lung cancer is one of the deadliest cancers, histologically divided into small cell lung cancer and non-small cell lung cancer, with the latter accounting for 80% of lung cancer cases. Non-small cell lung cancer is divided into three subtypes: adenocarcinoma, squamous cell carcinoma and large cell carcinoma. Adenocarcinoma, the most dominant subtype, accounts for 40% of NSCLC. The prognosis of non-small cell lung cancer depends heavily on the stage of the disease at the time of diagnosis. According to the current treatment lev...

Claims

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