Application of Bacillus coagulans to preparing composite preparations for preventing and treating shit odor and shit odor poisoning syndrome

A technology of Bacillus coagulans and syndrome, which is applied in the field of stool odor and stool odor poisoning syndrome, and can solve the problems of not much and lack of awareness of harmfulness.

Inactive Publication Date: 2010-12-29
QINGDAO EASTSEA PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But because people are not enough to the hazard understanding of fecal odor and fecal odor poisoning syndrome, scientific worker is also few to this aspect research, for this reason, the purpose of the present inventor will be exactly in micro-ecological innovative drug research, develops Probiotics, prebiotics, or a combination of probiotics and prebiotics for the prevention or treatment of fecal odor and fecal odor poisoning syndrome, this patent is hereby applied for

Method used

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  • Application of Bacillus coagulans to preparing composite preparations for preventing and treating shit odor and shit odor poisoning syndrome
  • Application of Bacillus coagulans to preparing composite preparations for preventing and treating shit odor and shit odor poisoning syndrome
  • Application of Bacillus coagulans to preparing composite preparations for preventing and treating shit odor and shit odor poisoning syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 Bacillus coagulans and Clostridium butyricum live bacteria are on the impact of ammonia and amine content in mouse feces

[0035] Method: 50 ICR purebred mice were divided into 5 groups, 10 mice in each group, and 10 live bacteria of Bacillus coagulans and Clostridium butyricum were used respectively. 9 cfu, 10 8 cfu / ml and physiological sodium chloride solution, 0.5ml / only, ig, once a day for a total of 21 days. The day before the end of the experiment, divide the mice into cages, one in each cage, take an equal amount of feces from each mouse, soak them in normal saline, then centrifuge to get the supernatant, and measure the amine value (μg / g) in the feces by titration . After the mice were sacrificed, the cecum was weighed, cut open in saline, and the contents were mixed well, then centrifuged to obtain the supernatant, and the ammonia value (μg / g) in the contents was determined with a corresponding kit.

[0036] Results Both Bacillus coagulans and C...

Embodiment 2

[0043] Example 2 Effects of Bacillus coagulans Live Bacteria Tablets and Clostridium Butyricum Capsules on Indole and Skatole Content in Human Feces

[0044] Methods HP-6890 gas chromatograph was used to determine the content of indole and skatole in the feces of 16 volunteers with informed consent. That is, take 0.5g of fresh feces and accurately weigh it, put it in a 50ml Erlenmeyer flask, add 20ml of ethanol for ultrasonic extraction for 20 minutes, filter, add 3ml of internal standard solution (0.1% p-Isopropylphenol), dilute to a 25ml measuring bottle, and measure 4 μl of the solution was injected into a chromatographic column (HP-INNO WAX glass capillary column, 30m×0.53mm, filled with 17% Silicone SE-30) for analysis. The measurement conditions are: column temperature: 200°C; inlet temperature: 230°C, detector temperature: 260°C, carrier gas flow rate N 2 90ml / min; H 2 Flow: 58ml / min; air flow: 60ml / min.

[0045] 16 volunteers, 6 males and 10 females, aged 25-55 year...

Embodiment 3

[0050] Example 3 Effects of Bacillus coagulans Live Bacteria Tablets on the Odor and Shape of Human Feces, etc.

[0051] Methods In the case of informed consent, 42 volunteers, 20 males and 22 females, aged 20-30 years old, maintained a normal diet and took live Bacillus coagulans tablets after meals, 3 tablets each time, 3 times a day, for 7 days in a row. sky. During the period of taking the medicine, observe the shape of the stool (normal-banana shape, strip shape, abnormal-chestnut shape, lumpy shape, muddy shape), hardness (normal-soft, abnormal-slightly hard, dry, hard), color ( Normal-yellow, light yellow-brown, yellow-colored, abnormal-dark brown, black, gray) and smell of stool (normal-smelling, abnormal-smell, very smelly, foul smell) and other conditions, Then count the test results.

[0052] Results The odor, shape, hardness, color and certain symptoms of the gastrointestinal tract of the volunteers after taking the medicine were significantly improved compared w...

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Abstract

The invention discloses novel medical application of Bacillus coagulans, and in particular relates to application of the Bacillus coagulans as an active ingredient to preparing preparations for preventing and controlling shit odor and shit odor poisoning syndrome caused by shit odor toxin generated by harmful bacteria.

Description

[0001] illustrate [0002] This application is a divisional application, the original application date: June 26, 2006, the original application number: 200610086642.3, the original invention creation name: probiotics, prebiotics for preventing and treating fecal odor and fecal odor poisoning syndrome and their composition preparations. technical field [0003] The present invention relates to stool odor and fecal odor poisoning syndrome caused by intestinal harmful bacteria producing fecal odor toxin, including its related symptoms and related diseases, especially the method also includes administering an effective amount of the present invention to the selected object. Defined probiotics, prebiotics for the prophylaxis or treatment of fecal odor and malodorous syndrome and compositions for this (synbiotics). Background technique [0004] There are 6.5 billion people in the world, and everyone has to eat every day. The food they eat is digested in the stomach and small intes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61P1/00A61K35/742
CPCY02A50/30
Inventor 崔云龙
Owner QINGDAO EASTSEA PHARMA
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