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Chinese medicinal chewable tables for treating diarrhea and preparation method thereof

A technology of chewable tablets and traditional Chinese medicine, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems that the decoction process cannot meet the needs of disease treatment and the time spent by patients. Achieve the effects of accelerating drug dissolution, improving curative effect, and large drug loading

Inactive Publication Date: 2012-10-03
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The way of taking it is to decoct it into a decoction and take it orally, but the traditional decoction process requires patients to spend time and money to achieve it.
[0003] Under the environmental conditions of no water in the wild and pollution of special environmental water sources such as wartime, emergency rescue and disaster relief, the traditional decoction process cannot meet the needs of disease treatment

Method used

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  • Chinese medicinal chewable tables for treating diarrhea and preparation method thereof
  • Chinese medicinal chewable tables for treating diarrhea and preparation method thereof
  • Chinese medicinal chewable tables for treating diarrhea and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Preparation method of traditional Chinese medicine chewable tablet

[0021] A preparation method of a Chinese medicine chewable tablet for treating diarrhea, comprising the steps of:

[0022] (1), weigh 1500g of red stone fat, 450g of dried ginger and 1500g of japonica rice;

[0023] (2) Put the coarse powder through a 10-mesh sieve after pulverizing the red stone fat and japonica rice into the reactor, slowly add 24L of distilled water and decoct for 1 hour. After the decoction is completed, the decoction is concentrated at a temperature of 50°C and a relative pressure of 0.07-0.08MPa. After the relative density of the solution is 1.3-1.4g / ml, it is transferred to a vacuum oven at 50°C and dried under reduced pressure to Constant weight, to obtain a dry product, after ultra-fine grinding to obtain red stone fat-japonica rice ultra-fine powder;

[0024] (3), take by weighing dried ginger pulverized and cross the coarse powder of 24 mesh sieves, at extracti...

Embodiment 2

[0027] Example 2: Preparation method of traditional Chinese medicine chewable tablet

[0028] This example is basically the same as Example 1, the difference is that in step (4) in this example, red stone fat-japonica rice superfine powder and dried ginger volatile oil β-cyclodextrin inclusion compound are mixed at a mass ratio of 65.6:1.

Embodiment 3

[0029] Example 3: Preparation method of traditional Chinese medicine chewable tablet

[0030] The operation process of this embodiment is the same as that of Example 1, the difference is that in step (3) the process of preparing the inclusion compound of dried ginger volatile oil β-cyclodextrin from the dried ginger volatile oil: Weigh 42g of β-cyclodextrin and place it in a 1L container In the reactor, add distilled water 525ml (wherein β-CD: water is 1: 12.5 (m / v)), under the condition of constant temperature 30 ± 1 ℃, stir with 200r / min to make it mix evenly, adjust the temperature of the heater , make the temperature of reaction solution rise to 40 ± 1 ℃, constant temperature, measure the ethanol solution 10.4ml (volatile oil: dehydrated alcohol 1: 1, v / v) that dissolves the volatile oil of dried ginger that 5.2ml is newly extracted, at 200r / Under the condition of stirring for 1 min, slowly add ethanol solution containing 50% volatile oil dropwise (about 30 minutes). S...

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PUM

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Abstract

The invention discloses Chinese medicinal chewable tables for treating diarrhea and a preparation method thereof and belongs to the technical field of Chinese medicinal preparations. The method for preparing the Chinese medicinal chewable tables comprises the following steps of: (1) preparing halloysit-round grained rice submicron powder; (2) preparing a dried ginger essential oil beta-cyclodextrin inclusion compound; and (3) after products obtained in the step (1) and the step (2) are mixed, adding pharmaceutical adjuvants, pelletizing and tabletting the mixture to obtain the Chinese medicinal chewable tables for treating the diarrhea. The Chinese medicinal chewable tables comprise active ingredients which consist of the halloysit-round grained rice submicron powder and the dried ginger essential oil beta-cyclodextrin inclusion compound and a pharmaceutically acceptable carrier. The Chinese medicinal chewable tables have the advantage of large loading rate, and can be swallowed directly after being chewed; a patient can take the tables on time under the condition of dehydration; and medicaments can be dissolved out rapidly and curative effect is increased.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine chewable tablet for treating diarrhea and a preparation method thereof. Background technique [0002] The prescription of "Taohua Decoction" comes from the famous prescription for treating diarrhea in "Treatise on Febrile Diseases" written by Zhang Zhongjing, a famous medical scientist in the Eastern Han Dynasty. composition. Its administration method is decocted into a decoction orally, but the traditional decoction process requires patients to spend time and financial resources to achieve. [0003] Under the environmental conditions of no water in the wild and pollution of special environmental water sources such as wartime, emergency rescue and disaster relief, the traditional decoction process cannot meet the needs of disease treatment. Contents of the invention [0004] In order to further impro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K9/20A61K47/48A61P1/12A61K35/24A61K47/69
Inventor 赵艳玲肖小河鄢丹山丽梅
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL