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Method for preparing sesamin and sesamolin

A technology of sesamolin and sesamin, which is applied in the field of manufacturing high-purity sesamin and sesamolin, can solve the problems of harmfulness to human health, only 78.5%, inconvenient operation, etc., achieve high recovery rate, good purification effect, and easy operation easy effect

Inactive Publication Date: 2011-01-12
FLAVOR FULL FOODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the recovery rate of sesamin is only 78.5%, and the method must cut the neutral alumina in the middle part of the columnar container during operation, and carry out reflux with more than 70% ethanol solution to extract sesamin
This cutting step not only interrupts the continuous operation and causes inconvenience to the operation, thus reducing the work efficiency, but also easily causes the volatilization of the solvent and pollutes the working environment, which is harmful to human health

Method used

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  • Method for preparing sesamin and sesamolin
  • Method for preparing sesamin and sesamolin
  • Method for preparing sesamin and sesamolin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]Get 50g of sesame oil (0.65% of sesamin content; 0.31% of sesamolin content), add 50mL of n-hexane and mix well, then pass the mixed solution through the tube filled with silica gel (10g; 70 to 230 mesh (mesh)) column (22mm×55mm), and the oil remaining in the column was eluted with n-hexane, and the oil was further removed from the n-hexane by volatilization under reduced pressure, and analyzed by HPLC. The obtained analysis results showed that there was no Sesamin and sesamolin were not detected, which means that the sesamin and sesamolin in the sesame oil have been completely absorbed by the silica gel and will not be washed out by n-hexane. Then, use ethyl acetate to elute the column until the eluate is colorless. Subsequently, the eluate was evaporated under reduced pressure to remove the solvent, and the yield was calculated to be 4.9% after weighing. The volatilized eluate was dissolved in ethyl acetate and diluted appropriately, then analyzed by HPLC, and the tot...

Embodiment 2 to 5

[0043] Operate according to the method of Example 1, but the elution solvent ethyl acetate used is then respectively replaced with acetone, methanol, ethanol and n-hexane-ethyl acetate (1: 1) for elution, and the obtained sesamin and The total recoveries of sesamolin were 95.8%, 95.8%, 89.6% and 95.8% in sequence, and the results are summarized in Table 1 below.

[0044] Table 1. The results of silica gel adsorption and elution of sesame oil with different solvents

[0045]

[0046] Note: 50g of raw material (sesame oil) contains 0.325g of sesamin and 0.155g of sesamolin, totaling 0.48g.

Embodiment 6

[0048] Operate according to the method of Example 1, but replace n-hexane with petroleum ether. The results showed that the total recovery rate of the obtained sesamin and sesamolin was 96.4%.

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Abstract

The invention provides a method for preparing sesamin and sesamolin, which comprises the following steps of allowing mixed solution of grease containing the sesamin and the sesamolin and an aliphatic hydrocarbon solvent to pass through a silica gel tubular column, eluting the silica gel tubular column through the aliphatic hydrocarbon solvent, and eluting the sesamin and the sesamolin which are absorbed by the silica gel tubular column through an elution solvent of a group formed by methanol, ethanol, acetone and ethyl acetate. The method for preparing the sesamin and the sesamolin has the advantages of simple and convenient operation, good purification effect and high recovery rate, and has practical value in relevant industry.

Description

technical field [0001] The invention relates to a technology for producing sesamin and sesamolin, in particular to a method for producing high-purity sesamin and sesamolin. Background technique [0002] Since ancient times, sesame has always been regarded as a holy food for health preservation. According to the records of "Shen Nong's Materia Medica": "Flax, sweet and flat, the main injury is empty, nourishes the five internal organs, strengthens energy, grows muscles, fills the brain, lightens the body for a long time, and strengthens the muscles and bones. , take it for a long time, you can hear and see clearly, you will not be hungry, you will not grow old, and you will live longer." [0003] In addition, according to the results of scientific research in recent years, it was found that sesamin and sesamolin contained in sesame seeds have many good physiological activities, including anti-oxidative activity, enhancing tocopherol in vivo ), promote lipid metabolism, lowe...

Claims

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Application Information

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IPC IPC(8): C07D493/04B01D15/08
CPCC07D493/04
Inventor 李敏雄
Owner FLAVOR FULL FOODS