Method for preparing novel mesoporous silica nano balls

A nanocrystal, a certain amount of technology, applied in the direction of silicon dioxide, silicon oxide, chemical instruments and methods, etc., to achieve the effect of easy biocompatibility, simple operation and good repeatability

Inactive Publication Date: 2011-01-19
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, how to obtain porous nanocapsules and nanospheres with controllable size and sha

Method used

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  • Method for preparing novel mesoporous silica nano balls
  • Method for preparing novel mesoporous silica nano balls
  • Method for preparing novel mesoporous silica nano balls

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Use a graduated cylinder to measure 40 mL of diethyl ether (CH 3 OCH 3 ) and 8mLH 2 O was poured into a 100mL sealed round-bottomed flask with a stopper, and magnetically stirred at room temperature to mix evenly;

[0020] (2) Then slowly add 1mL ammonia water (NH 4 OH) and 2mL tetraethyl orthosilicate (TEOS), continue stirring for 3 hours;

[0021] (3) Gradually slowly add 2 mL of TEOS and 1.0 g of cetyltrimethylammonium bromide (CTAB) to the above solution, and slowly stir and react for 5 hours;

[0022] (4) Put the mixed solution of the previous step into a high-pressure reactor, put it in an oven at 120° C., and react for 20 hours;

[0023] (5) Take out the mixed solution and wash it repeatedly with distilled water and ethanol, then centrifuge to remove the lower layer of precipitate, and finally place the precipitate in

[0024] Dry in an oven at 60°C to obtain porous SiO 2 nanospheres.

Embodiment 2

[0026] Implementation process step is except following difference, and other is all identical with embodiment 1

[0027] In step (2), slowly add 1 mL of ammonia water (NH 4 OH) and 2mL tetraethyl orthosilicate (TEOS), continue stirring for 1 hour;

[0028] In step (3), slowly add 2 mL of TEOS and 0.8 g of cetyltrimethylammonium bromide (CTAB) to the solution gradually, and slowly stir for 3 hours to react;

[0029] The obtained result is substantially similar to Example 1, except that SiO 2 The diameter of the nanospheres is slightly smaller than that of Example 1.

Embodiment 3

[0031] Implementation process step is except following difference, and other is all identical with embodiment 1

[0032] In step (2), slowly add 1 mL of ammonia water (NH 4 OH) and 1 mL tetraethyl orthosilicate (TEOS), continue to stir and react for 2 hours;

[0033] In step (3), slowly add 1 mL of TEOS and 1.0 g of cetyltrimethylammonium bromide (CTAB) to the solution gradually, and slowly stir for 5 hours;

[0034] The result is substantially similar to Example 1, except that SiO 2 The yield of nanospheres decreased somewhat, and the resulting SiO 2 Nanoballs are a little on the small side.

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Abstract

The invention relates to a method for preparing novel mesoporous silica nano balls, and belongs to the technical field of inorganic chemistry and material synthesis. The method comprises the following main steps of: mixing a certain amount of diethyl ether, deionized water, ammonia water and tetraethoxysilane for reaction, adding a certain amount of tetraethoxysilane and cetyl trimethyl ammonium bromide (serving as a template agent), putting into a high pressure reactor, and performing reaction at 120 DEG C for 12 to 24 hours; and cleaning with the deionized water and ethanol solution, performing centrifugal separation, drying the sedimentation, and finally obtaining the mesoporous silica nano balls. The material has the advantages of high chemical stability and no toxin, and is expected to be applied to the aspect of biomedicines, such as fields of controlled release of medicines, biosensors and cell marking.

Description

technical field [0001] The invention relates to a preparation method of a novel mesoporous silica nanosphere, which belongs to the technical field of inorganic chemistry and material synthesis. Background technique [0002] Since 1992, scientists from Mobil Corporation of the United States used nanostructure self-assembly technology for the first time, using quaternary ammonium salt cationic surfactants as templates to prepare MCM-41 with uniform channels and adjustable pore diameters. Since mesoporous materials are easy to Modified inner surface and high specific surface area, narrow pore size distribution, regular pore arrangement and composition flexibility, etc., have good permeability, adsorption performance and ability to sieve molecules, so in catalysis, adsorption and Separation, drug delivery and other fields have extremely broad application prospects. At present, the direct embedding and controlled release of drugs is a good application field of ordered mesoporous...

Claims

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Application Information

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IPC IPC(8): C01G49/00C01B33/12
Inventor 张海娇焦正李智勇张宗南张璐李霞
Owner SHANGHAI UNIV
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