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Preparation method of tuber fleeceflower root formulation granules

A technology of formula granules and Polygonum multiflorum, which is applied in the direction of medical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems that the preparation process of Polygonum multiflorum formula granules has not been reported in literature, etc., so that the effective ingredients will not be lost, and the improvement will be improved. Dissolution rate, obvious curative effect

Inactive Publication Date: 2011-02-09
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the preparation of Polygonum multiflorum traditional Chinese medicine adopts traditional Chinese medicine decoction, and there is no literature report on the preparation process of Polygonum multiflorum formula granules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Take 25g Polygonum multiflorum decoction pieces, add 8 times the amount of water for the first time, soak for 1.5 hours, decoct for 2 hours; add 10 times the amount of water for the second time, decoct for 2 hours; add 12 times the amount of water for the third time, decoct for 2 hours, Combine decoction. High-speed centrifugation, vacuum concentration of 0.06MPa under reduced pressure to a clear paste with a relative density of about 1.10 (60°C); spray drying, the air inlet temperature of the spray dryer is 165°C, and the air outlet temperature is 85°C to make dry paste powder; For dry cream powder, add dextrin and mix evenly at a ratio of 1:2 (the specific amount is combined with the detection of stilbene glycoside content, so that the stilbene glycoside content (weight) content is not less than 2.52%), and the soft material is made of 80% ethanol, Extrude and granulate, and dry.

Embodiment 2

[0014] Take 25g Polygonum multiflorum decoction pieces, add 8 times the amount of water for the first time, soak for 1.5 hours, decoct for 2 hours; add 8 times the amount of water for the second time, decoct for 1 hour; add 8 times the amount of water for the third time, decoct for 1 hour, Combine decoction. High-speed centrifugation, vacuum concentration of 0.08MPa under reduced pressure to a clear paste with a relative density of about 1.10 (60°C); spray drying, the air inlet temperature of the spray dryer is 160°C, and the air outlet temperature is 75°C to make dry paste powder; Dry cream powder, add dextrin about 1:2 and mix well, make soft material with 80% ethanol, extrude and granulate, dry to obtain.

Embodiment 3

[0016] Take 25g Polygonum multiflorum decoction pieces, add 6 times the amount of water for the first time, soak for 1.5 hours, decoct for 1.5 hours; add 8 times the amount of water for the second time, decoct for 1 hour; add 8 times the amount of water for the third time, decoct for 1 hour, Combine decoction. High-speed centrifugation, vacuum concentration of 0.08MPa under reduced pressure to a clear paste with a relative density of about 1.10 (60°C); spray drying, the air inlet temperature of the spray dryer is 160°C, and the air outlet temperature is 75°C to make dry paste powder; Dry cream powder, add dextrin about 1:2 and mix well, make soft material with 80% ethanol, extrude and granulate, dry to obtain.

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PUM

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Abstract

The invention discloses a preparation method of tuber fleeceflower root formulation granules. The preparation method comprises the following processing steps of: selecting the tuber fleeceflower root as a raw material, rinsing, drying to soft at 60 DEG C, slicing while hot, and drying at 55 DEG C to obtain tuber fleeceflower root slices for decoction; decocting the slices in water, centrifugally separating, concentrating the separated liquid under reduced pressure to obtain an extract with 1.04-1.10 relative density; carrying out spray-drying on the extract to prepare a dry extract power; adding dextrin into the extract powder, uniformly mixing, adjusting the weight content of stilbene glycoside to be not less than 2.52%, preparing a soft material by using 80% ethanol, extruding, granulating and drying to obtain the target drug. The preparation method is a water extraction process, the imitated decoction characteristics of the formulation granules are fully considered so that the stilbene glycoside type and anthraquinone glycoside type compounds have high dissolution rate, and the curative effect of the formulation granules is exerted.

Description

technical field [0001] The invention relates to the technical field of preparation of traditional Chinese medicine formula granules, especially the preparation method of Polygonum multiflorum formula granules. Background technique [0002] Radix Polygoni Multifiori (Radix Polygoni Multifiori) is the dry tuber root of Polygonum multiflora (Follopia multiflora (Thunb.) Harald.), which has the functions of nourishing liver and kidney, nourishing essence and blood, blackening hair, strengthening muscles and bones, and mainly treating blood deficiency and chlorosis, dizziness and tinnitus, Premature graying of the beard and hair, soreness of the waist and knees, numbness of the limbs, metrorrhagia and vaginal discharge, chronic malaria and physical weakness. [0003] Traditional Chinese medicine formula granules are a breakthrough in the application form of traditional Chinese medicine decoction pieces in the past ten years. They are mainly made of Chinese medicine decoction piec...

Claims

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Application Information

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IPC IPC(8): A61P19/08A61P1/08A61K36/704A61P1/14A61K125/00A61P15/00A61K9/16A61P27/16A61P7/06
Inventor 吴晓青童妍马超英耿耘
Owner SOUTHWEST JIAOTONG UNIV
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