Synthetic method of methyl (ethyl) phenyl acetate

Abstract

The invention discloses a synthetic method of methyl (ethyl) phenyl acetate, characterized by using benzyl chloride as a main raw material and adding and hydrolyzing a Grignard reagent and methyl carbonate to obtain a product. The invention adopts the technical scheme comprising the following steps of: adding 24g of magnesium, 300 ml of aether and 10g of benzyl chloride to a three-neck bottle of 2000 ml; starting to stir for 10 min; dropping 120g of benzyl chloride with a drop funnel; controlling the micro-refluxing state temperature of the aether; and adding the Grignard reagent and the methyl carbonate, and adding 600g of ice water to hydrolyze to obtain a product. The invention has the advantages that the process of the invention avoids using virulent sodium cyanide and has safe, simple and convenient operation, higher product quality and lower cost.

Description

technical field

[0001] The invention relates to a method for preparing food essence, in particular to a method for synthesizing methyl (b) phenylacetate, which belongs to the technical field of edible essence. Background technique

[0002] At present, the synthesis methods of methyl (b) phenylacetate mainly include the following: a. Oxidize "phenylacetic acid" with "phenylethyl alcohol", and then obtain it through esterification with "methanol"; b. Use "benzyl chloride" and "cyanide" Condensate with sodium cyanide to obtain "phenylacetonitrile", after acidic hydrolysis to obtain "phenylacetic acid", and then esterify with "methanol" to obtain "methyl phenylacetate"; c. Condensate with "sodium cyanide" to obtain "phenylacetonitrile", After alcoholysis with methanol, "methyl phenylacetate" can be obtained. Among the above three methods: Method 1 has basically been eliminated due to the high price of the raw material "phenylethyl alcohol", complex oxidation products and low yi...