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Synthetic method of methyl (ethyl) phenyl acetate

A technology of methyl phenylacetate and a synthesis method, applied in the field of edible flavors, can solve the problems of high price, low product quality, complicated oxidation products, etc., and achieve the effects of low price, high product quality and safe operation

Inactive Publication Date: 2011-02-16
杨亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among the above three methods: Method 1 has basically been eliminated due to the high price of the raw material "phenylethyl alcohol", complex oxidation products and low yield, resulting in low product quality and high cost; method 2 and method 3 are both The highly toxic sodium cyanide to be used has extremely high requirements on personnel, equipment, safety and environmental protection, and is not suitable for general small and medium-sized enterprises.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0006] Embodiment 1: 24 grams of magnesium, 300 ml of ether, and 10 grams of benzyl chloride were added to a 2000 ml there-necked flask, and stirring was started for 10 minutes to allow the reaction to start naturally. After the reaction was completed, 120 grams of benzyl chloride was added dropwise through the dropping funnel, During the dropping process, control the diethyl ether in the bottle to be in a slight reflux state; after the dropping, start stirring and continue the reflux reaction for 1 to 3 hours; add a low-temperature tank to cool down, and when the inner temperature of the bottle reaches -10 to 10°C, add dimethyl carbonate (B) dropwise 90 grams of ester, temperature control during the dropping process -10 ~ 10 ℃, continue to keep warm for 1 ~ 3 hours after the drop; add 600 grams of ice water to the bottle for hydrolysis, neutralize with hydrochloric acid to PH = 7 ~ 8 after hydrolysis, and then The material was transferred to a separatory funnel for static laye...

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PUM

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Abstract

The invention discloses a synthetic method of methyl (ethyl) phenyl acetate, characterized by using benzyl chloride as a main raw material and adding and hydrolyzing a Grignard reagent and methyl carbonate to obtain a product. The invention adopts the technical scheme comprising the following steps of: adding 24g of magnesium, 300 ml of aether and 10g of benzyl chloride to a three-neck bottle of 2000 ml; starting to stir for 10 min; dropping 120g of benzyl chloride with a drop funnel; controlling the micro-refluxing state temperature of the aether; and adding the Grignard reagent and the methyl carbonate, and adding 600g of ice water to hydrolyze to obtain a product. The invention has the advantages that the process of the invention avoids using virulent sodium cyanide and has safe, simple and convenient operation, higher product quality and lower cost.

Description

technical field [0001] The invention relates to a method for preparing food essence, in particular to a method for synthesizing methyl (b) phenylacetate, which belongs to the technical field of edible essence. Background technique [0002] At present, the synthesis methods of methyl (b) phenylacetate mainly include the following: a. Oxidize "phenylacetic acid" with "phenylethyl alcohol", and then obtain it through esterification with "methanol"; b. Use "benzyl chloride" and "cyanide" Condensate with sodium cyanide to obtain "phenylacetonitrile", after acidic hydrolysis to obtain "phenylacetic acid", and then esterify with "methanol" to obtain "methyl phenylacetate"; c. Condensate with "sodium cyanide" to obtain "phenylacetonitrile", After alcoholysis with methanol, "methyl phenylacetate" can be obtained. Among the above three methods: Method 1 has basically been eliminated due to the high price of the raw material "phenylethyl alcohol", complex oxidation products and low yi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/614C07C67/00
Inventor 杨亮
Owner 杨亮
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